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1.
J Clin Microbiol ; 53(4): 1342-4, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25609720

RESUMO

The EasyNAT assay was evaluated for the detection of tuberculosis in sputum smears from presumptive pulmonary tuberculosis (TB) patients in an African high-TB and high-HIV setting. The sensitivity of the EasyNAT assay was 66.7%, and the specificity and positive predictive value were 100% for the culture-positive patients. The sensitivity was only 10% in the smear-negative and culture-positive patients.


Assuntos
Mycobacterium tuberculosis/isolamento & purificação , Kit de Reagentes para Diagnóstico , Escarro/microbiologia , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/microbiologia , Técnicas Bacteriológicas , Humanos , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Tanzânia/epidemiologia , Tuberculose Pulmonar/epidemiologia
2.
PLoS One ; 9(9): e106381, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25192172

RESUMO

BACKGROUND: Chest radiography to diagnose and screen for pulmonary tuberculosis has limitations, especially due to inter-reader variability. Automating the interpretation has the potential to overcome this drawback and to deliver objective and reproducible results. The CAD4TB software is a computer-aided detection system that has shown promising preliminary findings. Evaluation studies in different settings are needed to assess diagnostic accuracy and practicability of use. METHODS: CAD4TB was evaluated on chest radiographs of patients with symptoms suggestive of pulmonary tuberculosis enrolled in two cohort studies in Tanzania. All patients were characterized by sputum smear microscopy and culture including subsequent antigen or molecular confirmation of Mycobacterium tuberculosis (M.tb) to determine the reference standard. Chest radiographs were read by the software and two human readers, one expert reader and one clinical officer. The sensitivity and specificity of CAD4TB was depicted using receiver operating characteristic (ROC) curves, the area under the curve calculated and the performance of the software compared to the results of human readers. RESULTS: Of 861 study participants, 194 (23%) were culture-positive for M.tb. The area under the ROC curve of CAD4TB for the detection of culture-positive pulmonary tuberculosis was 0.84 (95% CI 0.80-0.88). CAD4TB was significantly more accurate for the discrimination of smear-positive cases against non TB patients than for smear-negative cases (p-value<0.01). It differentiated better between TB cases and non TB patients among HIV-negative compared to HIV-positive individuals (p<0.01). CAD4TB significantly outperformed the clinical officer, but did not reach the accuracy of the expert reader (p = 0.02), for a tuberculosis specific reading threshold. CONCLUSION: CAD4TB accurately distinguished between the chest radiographs of culture-positive TB cases and controls. Further studies on cost-effectiveness, operational and ethical aspects should determine its place in diagnostic and screening algorithms.


Assuntos
Radiografia Torácica , Tuberculose Pulmonar/diagnóstico por imagem , Adulto , África Subsaariana , Feminino , Soropositividade para HIV , Humanos , Masculino , Pessoa de Meia-Idade , Curva ROC , Radiografia Torácica/normas , Reprodutibilidade dos Testes , Fatores de Risco , Sensibilidade e Especificidade , Tomografia Computadorizada por Raios X , Adulto Jovem
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