Pesquisa | BVS Violência e Saúde

1.

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids.

Yang, Hui; Eremeeva, Elena; Abramov, Mikhail; Jacquemyn, Maarten; Groaz, Elisabetta; Daelemans, Dirk; Herdewijn, Piet.

Nucleic Acids Res ; 51(4): 1501-1511, 2023 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-36611237

2.

Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif.

Schofield, Peter; Taylor, Alexander I; Rihon, Jérôme; Peña Martinez, Cristian D; Zinn, Sacha; Mattelaer, Charles-Alexandre; Jackson, Jennifer; Dhaliwal, Gurpreet; Schepers, Guy; Herdewijn, Piet; Lescrinier, Eveline; Christ, Daniel; Holliger, Philipp.

Nucleic Acids Res ; 51(15): 7736-7748, 2023 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-37439359

3.

Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.

Singh, Abhimanyu K; De Wijngaert, Brent; Bijnens, Marc; Uyttersprot, Kris; Nguyen, Hoai; Martinez, Sergio E; Schols, Dominique; Herdewijn, Piet; Pannecouque, Christophe; Arnold, Eddy; Das, Kalyan.

Proc Natl Acad Sci U S A ; 119(30): e2203660119, 2022 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-35858448

4.

Impact of Single Acyclic Phosphonate Nucleotide (ZNA) Modifications on DNA Duplex Stability.

Li, Xinlu; Groaz, Elisabetta; Herdewijn, Piet; Lescrinier, Eveline.

Chemistry ; : e202401254, 2024 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-38687344

5.

Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.

Hajjar, Mohammad; Chim, Nicholas; Liu, Chao; Herdewijn, Piet; Chaput, John C.

Nucleic Acids Res ; 50(17): 9663-9674, 2022 09 23.

Artigo em Inglês | MEDLINE | ID: mdl-36124684

6.

Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis.

Rietmeyer, Lauriane; Li De La Sierra-Gallay, Inès; Schepers, Guy; Dorchêne, Delphine; Iannazzo, Laura; Patin, Delphine; Touzé, Thierry; van Tilbeurgh, Herman; Herdewijn, Piet; Ethève-Quelquejeu, Mélanie; Fonvielle, Matthieu.

Nucleic Acids Res ; 50(20): 11415-11425, 2022 11 11.

Artigo em Inglês | MEDLINE | ID: mdl-36350642

7.

Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.

Pallan, Pradeep S; Lybrand, Terry P; Rozners, Eriks; Abramov, Mikhail; Schepers, Guy; Eremeeva, Elena; Herdewijn, Piet; Egli, Martin.

Biochemistry ; 62(19): 2854-2867, 2023 10 03.

Artigo em Inglês | MEDLINE | ID: mdl-37694722

8.

Controlled E. coli Aggregation Mediated by DNA and XNA Hybridization.

Gasse, Cécile; Srivastava, Puneet; Schepers, Guy; Jose, Joachim; Hollenstein, Marcel; Marlière, Philippe; Herdewijn, Piet.

Chembiochem ; 24(15): e202300191, 2023 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-37119472

9.

Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents.

Gao, Ling-Jie; Lin, Yuan; De Jonghe, Steven; Waer, Mark; Herdewijn, Piet.

Bioorg Med Chem Lett ; 95: 129490, 2023 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-37770001

10.

Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of ß-D-N⁴-hydroxycytidine (NHC) and a 3'-fluoro-substituted analogue of NHC.

Wen, Zhao-Hui; Wang, Meng-Meng; Li, Ling-Yun; Herdewijn, Piet; Snoeck, Robert; Andrei, Graciela; Liu, Zhao-Peng; Liu, Chao.

Bioorg Chem ; 135: 106527, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37031504

11.

In Vivo Assembly and Expression of DNA Containing Non-canonical Bases in the Yeast Saccharomyces cerevisiae.

Nguyen, Hoai; Abramov, Mikhail; Rozenski, Jef; Eremeeva, Elena; Herdewijn, Piet.

Chembiochem ; 23(11): e202200060, 2022 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-35322918

12.

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.

Kumar, Pawan; Degaonkar, Rohan; Guenther, Dale C; Abramov, Mikhail; Schepers, Guy; Capobianco, Marie; Jiang, Yongfeng; Harp, Joel; Kaittanis, Charalambos; Janas, Maja M; Castoreno, Adam; Zlatev, Ivan; Schlegel, Mark K; Herdewijn, Piet; Egli, Martin; Manoharan, Muthiah.

Nucleic Acids Res ; 48(8): 4028-4040, 2020 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-32170309

13.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.

Gao, Shenghua; Song, Letian; Xu, Hongtao; Fikatas, Antonios; Oeyen, Merel; De Jonghe, Steven; Zhao, Fabao; Jing, Lanlan; Jochmans, Dirk; Vangeel, Laura; Cheng, Yusen; Kang, Dongwei; Neyts, Johan; Herdewijn, Piet; Schols, Dominique; Zhan, Peng; Liu, Xinyong.

Molecules ; 28(1)2022 Dec 25.

Artigo em Inglês | MEDLINE | ID: mdl-36615354

14.

Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids.

Mattelaer, Charles-Alexandre; Maiti, Mohitosh; Smets, Laurent; Maiti, Munmun; Schepers, Guy; Mattelaer, Henri-Philippe; Rosemeyer, Helmut; Herdewijn, Piet; Lescrinier, Eveline.

Chembiochem ; 22(9): 1638-1645, 2021 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-33427360

15.

Catalysts from synthetic genetic polymers.

Taylor, Alexander I; Pinheiro, Vitor B; Smola, Matthew J; Morgunov, Alexey S; Peak-Chew, Sew; Cozens, Christopher; Weeks, Kevin M; Herdewijn, Piet; Holliger, Philipp.

Nature ; 518(7539): 427-30, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25470036

16.

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor.

Eremeeva, Elena; Fikatas, Antonios; Margamuljana, Lia; Abramov, Mikhail; Schols, Dominique; Groaz, Elisabetta; Herdewijn, Piet.

Nucleic Acids Res ; 47(10): 4927-4939, 2019 06 04.

Artigo em Inglês | MEDLINE | ID: mdl-30968117

17.

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases.

Renders, Marleen; Dumbre, Shrinivas; Abramov, Mikhail; Kestemont, Donaat; Margamuljana, Lia; Largy, Eric; Cozens, Christopher; Vandenameele, Julie; Pinheiro, Vitor B; Toye, Dominique; Frère, Jean-Marie; Herdewijn, Piet.

Nucleic Acids Res ; 47(5): 2160-2168, 2019 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-30698800

18.

Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.

Vanmeert, Michiel; Razzokov, Jamoliddin; Mirza, Muhammad Usman; Weeks, Stephen D; Schepers, Guy; Bogaerts, Annemie; Rozenski, Jef; Froeyen, Mathy; Herdewijn, Piet; Pinheiro, Vitor B; Lescrinier, Eveline.

Nucleic Acids Res ; 47(13): 7130-7142, 2019 07 26.

Artigo em Inglês | MEDLINE | ID: mdl-31334814

19.

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette.

Yang, Hui; Eremeeva, Elena; Abramov, Mikhail; Herdewijn, Piet.

Angew Chem Int Ed Engl ; 60(8): 4175-4182, 2021 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-33142013

20.

Orthogonal Genetic Systems.

Chaput, John C; Herdewijn, Piet; Hollenstein, Marcel.

Chembiochem ; 21(10): 1408-1411, 2020 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-31889390

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