The orbitofrontal cortex maps future navigational goals.

Accurate navigation to a desired goal requires consecutive estimates of spatial relationships between the current position and future destination throughout the journey. Although neurons in the hippocampal formation can represent the position of an animal as well as its nearby trajectories1-7, their role in determining the destination of the animal has been questioned8,9. It is, thus, unclear whether the brain can possess a precise estimate of target location during active environmental exploration. Here we describe neurons in the rat orbitofrontal cortex (OFC) that form spatial representations persistently pointing to the subsequent goal destination of an animal throughout navigation. This destination coding emerges before the onset of navigation, without direct sensory access to a distal goal, and even predicts the incorrect destination of an animal at the beginning of an error trial. Goal representations in the OFC are maintained by destination-specific neural ensemble dynamics, and their brief perturbation at the onset of a journey led to a navigational error. These findings suggest that the OFC is part of the internal goal map of the brain, enabling animals to navigate precisely to a chosen destination that is beyond the range of sensory perception.

Quantifying encoding redundancy induced by rate correlations in Poisson neurons.

Temporal correlations in neuronal spike trains are known to introduce redundancy to stimulus encoding. However, exact methods to describe how these correlations impact neural information transmission quantitatively are lacking. Here, we provide a general measure for the information carried by correlated rate modulations only, neglecting other spike correlations, and use it to investigate the effect of rate correlations on encoding redundancy. We derive it analytically by calculating the mutual information between a time-correlated, rate modulating signal and the resulting spikes of Poisson neurons. Whereas this information is determined by spike autocorrelations only, the redundancy in information encoding due to rate correlations depends on both the distribution and the autocorrelation of the rate histogram. We further demonstrate that at very small signal strengths the information carried by rate correlated spikes becomes identical to that of independent spikes, in effect measuring the signal modulation depth. In contrast, a vanishing signal correlation time maximizes information but does not generally yield the information of independent spikes. Overall, our study sheds light on the role of signal-induced temporal correlations for neural coding, by providing insight into how signal features shape redundancy and by establishing mathematical links between existing methods.

Information transmission of mean and variance coding in integrate-and-fire neurons.

Neurons process information by translating continuous signals into patterns of discrete spike times. An open question is how much information these spike times contain about signals which modulate either the mean or the variance of the somatic currents in neurons, as is observed experimentally. Here we calculate the exact information contained in discrete spike times about a continuous signal in both encoding strategies. We show that the information content about mean modulating signals is generally substantially larger than about variance modulating signals for biological parameters. Our analysis further reveals that higher information transmission is associated with a larger proportion of nonlinear signal encoding. Our study measures the complete information content of mean and variance coding and provides a method to determine what fraction of the total information is linearly decodable.

How linear response shaped models of neural circuits and the quest for alternatives.

In the past decades, many mathematical approaches to solve complex nonlinear systems in physics have been successfully applied to neuroscience. One of these tools is the concept of linear response functions. However, phenomena observed in the brain emerge from fundamentally nonlinear interactions and feedback loops rather than from a composition of linear filters. Here, we review the successes achieved by applying the linear response formalism to topics, such as rhythm generation and synchrony and by incorporating it into models that combine linear and nonlinear transformations. We also discuss the challenges encountered in the linear response applications and argue that new theoretical concepts are needed to tackle feedback loops and non-equilibrium dynamics which are experimentally observed in neural networks but are outside of the validity regime of the linear response formalism.