Thunder road - whole-body vibration during road cycling, and the effect of different seatpost designs to minimise it.

Exposure to whole-body vibration (WBV) increases the risk of low back pain, spinal degeneration, and injury. Cycling can expose participants to WBV, but there are limited data available. This preliminary study quantified WBV in road cyclists in accordance with ISO 2631-1, and determined the efficacy of two seatposts designed to minimise vibration, compared to an aluminium alloy seatpost. Sensors were used to measure the root-mean-squared acceleration (arms), frequency-weighted arms based on an eight-hour reference period (A(8)), vibration dose value (VDV), and transmissibility. Exposures were also calculated using the root-sum-of-squares of the frequency-weighted arms in all three axes (A(8)rss and VDVrss). The mean±95% confidence interval A(8)rss and VDVrss across all tests was 0.58 ± 0.07 ms-2 and 37.19 ± 4.70 ms-1.75 respectively at the saddle, if and 0.49 ± 0.06 ms-2 and 24.31 ± 2.89 ms-1.75 respectively at the lumbar position. Occupational limits were exceeded with all seatposts, and there were no significant differences between them (p > 0.227). Road cycling results in substantial WBV, and there was no evidence that the seatposts designed to minimise vibrations successfully do so. Further research into the effect of cycling conditions and equipment on WBV would be valuable to both the research and cycling communities.

The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales.

Low back pain is the leading cause of disability, producing a substantial socio-economic burden on healthcare systems worldwide. Intervertebral disc (IVD) degeneration is a primary cause of lower back pain, and while regenerative therapies aimed at full functional recovery of the disc have been developed in recent years, no commercially available, approved devices or therapies for the regeneration of the IVD currently exist. In the development of these new approaches, numerous models for mechanical stimulation and preclinical assessment, including in vitro cell studies using microfluidics, ex vivo organ studies coupled with bioreactors and mechanical testing rigs, and in vivo testing in a variety of large and small animals, have emerged. These approaches have provided different capabilities, certainly improving the preclinical evaluation of these regenerative therapies, but challenges within the research environment, and compromises relating to non-representative mechanical stimulation and unrealistic test conditions, remain to be resolved. In this review, insights into the ideal characteristics of a disc model for the testing of IVD regenerative approaches are first assessed. Key learnings from in vivo, ex vivo, and in vitro IVD models under mechanical loading stimulation to date are presented alongside the merits and limitations of each model based on the physiological resemblance to the human IVD environment (biological and mechanical) as well as the possible feedback and output measurements for each approach. When moving from simplified in vitro models to ex vivo and in vivo approaches, the complexity increases resulting in less controllable models but providing a better representation of the physiological environment. Although cost, time, and ethical constraints are dependent on each approach, they escalate with the model complexity. These constraints are discussed and weighted as part of the characteristics of each model.

The application of physiological loading using a dynamic, multi-axis spine simulator.

In-vitro testing protocols used for spine studies should replicate the in-vivo load environment as closely as possible. Unconstrained moments are regularly employed to test spinal specimens in-vitro, but applying such loads dynamically using an active six-axis testing system remains a challenge. The aim of this study was to assess the capability of a custom-developed spine simulator to apply dynamic unconstrained moments with an axial preload. Flexion-extension, lateral bending, and axial rotation were applied to an L5/L6 porcine specimen at 0.1 and 0.3Hz. Non-principal moments and shear forces were minimized using load control. A 500N axial load was applied prior to tests, and held stationary during testing to assess the effect of rotational motion on axial load. Non-principal loads were minimized to within the load cell noise-floor at 0.1Hz, and within two-times the load-cell noise-floor in all but two cases at 0.3Hz. The adoption of position control in axial compression-extension resulted in axial loads with qualitative similarities to in-vivo data. This study successfully applied dynamic, unconstrained moments with a physiological preload using a six-axis control system. Future studies will investigate the application of dynamic load vectors, multi-segment specimens, and assess the effect of injury and degeneration.

The dynamic, six-axis stiffness matrix testing of porcine spinal specimens.

BACKGROUND CONTEXT: Complex testing protocols are required to fully understand the biomechanics of the spine. There remains limited data concerning the mechanical properties of spinal specimens under dynamic loading conditions in six axes. PURPOSE: To provide new data on the mechanical properties of functional spinal unit (FSU) and isolated disc (ISD) spinal specimens in 6 df. STUDY DESIGN: Dynamic, six-axis stiffness matrix testing of porcine lumbar spinal specimens. METHODS: The stiffness matrix testing of lumbar porcine FSU (n=6) and ISD (n=6) specimens was completed in a custom six-axis spine simulator using triangle wave cycles at a frequency of 0.1 Hz. Specimens were first tested without an axial preload, then with an axial preload of 500 N, with equilibration times of both 30 and 60 minutes. RESULTS: The stiffness matrices were not symmetrical about the principal stiffness terms. The facets increased all the principal stiffness terms with the exception of axial compression-extension. Significant differences were detected in 15 stiffness terms because of the application of an axial preload in the ISD specimens, including an increase in all principal stiffness terms. There were limited differences in stiffness because of equilibration time of 30 and 60 minutes. CONCLUSIONS: The assumption of stiffness matrix symmetry used in many previous studies is not valid. The biomechanical testing of spinal specimens should be completed in 6 df, at physiologic loading rates, and incorporate the application of an axial preload. The present study has provided new data on the mechanical properties of spinal specimens and demonstrates that the dynamic stiffness matrix method provides a means to more fully understand the natural spine and quantitatively assess spinal instrumentation.

An investigation into axial impacts of the cervical spine using digital image correlation.

BACKGROUND CONTEXT: High-energy impacts are commonly encountered during sports such as rugby union. Although catastrophic injuries resulting from such impacts are rare, the consequences can be devastating for all those involved. A greater level of understanding of cervical spine injury mechanisms is required, with the ultimate aim of minimizing such injuries. PURPOSE: The present study aimed to provide a greater understanding of cervical spine injury mechanisms, by subjecting porcine spinal specimens to impact conditions based on those measured in vivo. The impacts were investigated using high-speed digital image correlation (DIC), a method not previously adopted for spinal impact research. STUDY DESIGN: This was an in vitro biomechanical study. METHODS: Eight porcine specimens were impacted using a custom-made rig. The cranial and caudal axial loads were measured at 1 MHz. Video data were captured with two cameras at 4 kHz, providing measurements of the three-dimensional deformation and surface strain field of the specimens using DIC. RESULTS: The injuries induced on the specimens were similar to those observed clinically. The mean±standard deviation peak caudal load was 6.0±2.1 kN, which occurred 5.6±1.1 ms after impact. Damage observable with the video data occurred in six specimens, 5.4±1.1 ms after impact, and the peak surface strain at fracture initiation was 4.6±0.5%. CONCLUSIONS: This study has provided an unprecedented insight into the injury mechanisms of the cervical spine during impact loading. The posture represents a key factor in injury initiation, with lordosis of the spine increasing the likelihood of injury.

The development of a dynamic, six-axis spine simulator.

BACKGROUND CONTEXT: Although a great deal of research has been completed to characterize the stiffness of spinal specimens, there remains a limited understanding of the spine in 6 df and there is a lack of data from dynamic testing in six axes. PURPOSE: This study details the development and validation of a dynamic six-axis spine simulator. STUDY DESIGN: Biomechanical study. METHODS: A synthetic spinal specimen was used for the purpose of tuning the simulator, completing positional accuracy tests, and measuring frequency response under physiological conditions. The spine simulator was used to complete stiffness matrix tests of an L3-L4 lumbar porcine functional spinal unit. Five testing frequencies were used, ranging from quasistatic (0.00575 Hz) to dynamic (0.5 Hz). Tests were performed without an axial preload and with an axial preload of 500 N. RESULTS: The validation tests demonstrated that the simulator is capable of producing accurate positioning under loading at frequencies up to 0.5 Hz using both sine and triangle waveforms. The porcine stiffness matrix tests demonstrated that the stiffness matrix is not symmetrical about the principal stiffness diagonal. It was also shown that while an increase in test frequency generally increased the principal stiffness terms, axial preload had a much greater effect. CONCLUSIONS: The spine simulator is capable of characterizing the dynamic biomechanics of the spine in six axes and provides a means to better understand the complex behavior of the spine under physiological conditions.