Assuntos
Metabolismo dos Carboidratos , Cloroquina/farmacologia , Pigmentos Biológicos/metabolismo , Plasmodium berghei/metabolismo , Animais , Cromatografia em Papel , Meios de Cultura , Cistina/metabolismo , Eritrócitos/análise , Glucose/metabolismo , Glicerol/metabolismo , Lactatos/metabolismo , Metionina/metabolismo , Camundongos , Biossíntese de Proteínas , RNA/biossínteseAssuntos
Consumo de Oxigênio , Plasmodium/metabolismo , Aerobiose , Anaerobiose , Antimicina A/farmacologia , Cianetos/farmacologia , Transporte de Elétrons/efeitos dos fármacos , Complexo IV da Cadeia de Transporte de Elétrons , Eritrócitos , Consumo de Oxigênio/efeitos dos fármacos , Plasmodium/efeitos dos fármacos , Plasmodium/enzimologia , Rotenona/farmacologiaRESUMO
The evidence for the pathways involved in the metabolism of carbohydrates by malarial parasites is critically reviewed. In all species studied, glucose is catabolized mainly by glycolysis with little participation of the pentose-phosphate pathway. It has not been proved conclusively that there is a functioning citric acid cycle in the intraerythrocytic stages of avian plasmodia, nor is it certain that these stages of any malarial parasites use oxygen.
Assuntos
Metabolismo dos Carboidratos , Plasmodium/metabolismo , Animais , Ciclo do Ácido Cítrico , Eritrócitos/metabolismo , Eritrócitos/parasitologia , Glicólise , Humanos , Leucócitos/metabolismo , Consumo de Oxigênio , Pentosefosfatos/metabolismo , Plasmodium/enzimologiaRESUMO
The red cells of malaria-infected mice and ducks have an increased permeability to glucose.
Assuntos
Glucose/metabolismo , Plasmodium/metabolismo , Animais , Eritrócitos/parasitologia , Humanos , CamundongosRESUMO
There have been many reports that intraerythrocytic Plasmodium berghei does not metabolize glucose completely to lactate. However, it appears that in some circumstances there can be interference with the assay of lactate. Correction by a dilution method suggests that in reality conversion is essentially complete.
Assuntos
Eritrócitos/metabolismo , Glucose/metabolismo , Lactatos/metabolismo , Plasmodium berghei/metabolismo , Animais , Eritrócitos/parasitologiaRESUMO
The structures of malarial and schistosomal pigment within the parasites are distinct. The two pigments are distinguishable both before and after extraction from host liver.
Assuntos
Pigmentos Biológicos/análise , Plasmodium berghei/análise , Schistosoma mansoni/análise , Animais , Artéria Hepática/parasitologia , Veias Hepáticas/parasitologia , Fígado/parasitologia , Malária/parasitologia , Camundongos , Microscopia Eletrônica , Plasmodium berghei/ultraestrutura , Schistosoma mansoni/ultraestruturaRESUMO
Malarial pigment from erythrocytes infected with Plasmodium berghei was purified by treatment with sodium dodecyl sulphate solution, followed by incubation with Pancreatin. The purified pigment retained the apparently crystalline form of pigment within the parasite, rotated polarised light and had the same solubility characterisation as crude malarial pigment. It contained about 1% iron, all of which could be accounted for in terms of haemin. The iron of the pigment molecule is oxidised by the parasite to the ferric state.