Pesquisa | BVS Violência e Saúde

1.

Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.

Garg, Bhavuk; Mehta, Hrishikesh M; Wang, Borwyn; Kamel, Ralph; Horwitz, Marshall S; Corey, Seth J.

J Biol Chem ; 295(21): 7492-7500, 2020 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-32299910

2.

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations.

Hart, Matthew R; Anderson, Donovan J; Porter, Christopher C; Neff, Tobias; Levin, Michael; Horwitz, Marshall S.

PLoS Genet ; 14(9): e1007642, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30216339

3.

GATA factor mutations in hematologic disease.

Crispino, John D; Horwitz, Marshall S.

Blood ; 129(15): 2103-2110, 2017 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-28179280

4.

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition.

Zhou, Wenyu; Choi, Michael; Margineantu, Daciana; Margaretha, Lilyana; Hesson, Jennifer; Cavanaugh, Christopher; Blau, C Anthony; Horwitz, Marshall S; Hockenbery, David; Ware, Carol; Ruohola-Baker, Hannele.

EMBO J ; 31(9): 2103-16, 2012 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-22446391

5.

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

Connelly, Jon P; Kwon, Erika M; Gao, Yongxing; Trivedi, Niraj S; Elkahloun, Abdel G; Horwitz, Marshall S; Cheng, Linzhao; Liu, P Paul.

Blood ; 124(12): 1926-30, 2014 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-25114263

6.

Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S.

Blood ; 123(4): 562-9, 2014 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-24184683

7.

Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy.

Krem, Maxwell M; Press, Oliver W; Horwitz, Marshall S; Tidwell, Timothy.

Br J Haematol ; 171(1): 13-28, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26018193

8.

Decoding cell lineage from acquired mutations using arbitrary deep sequencing.

Carlson, Cheryl A; Kas, Arnold; Kirkwood, Robert; Hays, Laura E; Preston, Bradley D; Salipante, Stephen J; Horwitz, Marshall S.

Nat Methods ; 9(1): 78-80, 2011 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-22120468

9.

Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.

Kazenwadel, Jan; Secker, Genevieve A; Liu, Yajuan J; Rosenfeld, Jill A; Wildin, Robert S; Cuellar-Rodriguez, Jennifer; Hsu, Amy P; Dyack, Sarah; Fernandez, Conrad V; Chong, Chan-Eng; Babic, Milena; Bardy, Peter G; Shimamura, Akiko; Zhang, Michael Y; Walsh, Tom; Holland, Steven M; Hickstein, Dennis D; Horwitz, Marshall S; Hahn, Christopher N; Scott, Hamish S; Harvey, Natasha L.

Blood ; 119(5): 1283-91, 2012 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-22147895

10.

The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability.

Krem, Maxwell M; Luo, Ping; Ing, Brandon I; Horwitz, Marshall S.

J Biol Chem ; 287(46): 39083-93, 2012 Nov 09.

Artigo em Inglês | MEDLINE | ID: mdl-22988245

11.

Use of somatic mutations to quantify random contributions to mouse development.

Zhou, Wenyu; Tan, Yunbing; Anderson, Donovan J; Crist, Eva M; Ruohola-Baker, Hannele; Salipante, Stephen J; Horwitz, Marshall S.

BMC Genomics ; 14: 39, 2013 Jan 18.

Artigo em Inglês | MEDLINE | ID: mdl-23327737

12.

Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.

Korkmaz, Brice; Horwitz, Marshall S; Jenne, Dieter E; Gauthier, Francis.

Pharmacol Rev ; 62(4): 726-59, 2010 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-21079042

13.

Derivation of Naïve Human Embryonic Stem Cells Using a CHK1 Inhibitor.

Ware, Carol B; Jonlin, Erica C; Anderson, Donovan J; Cavanaugh, Christopher; Hesson, Jennifer; Sidhu, Sonia; Cook, Savannah; Villagomez-Olea, Guillermo; Horwitz, Marshall S; Wang, Yuliang; Mathieu, Julie.

Stem Cell Rev Rep ; 19(8): 2980-2990, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37702917

14.

Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.

Aronchik, Ida; Chen, Tony; Durkin, Kathleen A; Horwitz, Marshall S; Preobrazhenskaya, Maria N; Bjeldanes, Leonard F; Firestone, Gary L.

Mol Carcinog ; 51(11): 881-94, 2012 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-22012859

15.

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes.

Horwitz, Marshall S; Efrat, Shimon; Christen, Urs; von Herrath, Matthias G; Oldstone, Michael B A.

Proc Natl Acad Sci U S A ; 106(46): 19450-4, 2009 Nov 17.

Artigo em Inglês | MEDLINE | ID: mdl-19887639

16.

Clonal expansions in ulcerative colitis identify patients with neoplasia.

Salk, Jesse J; Salipante, Stephen J; Risques, Rosa Ana; Crispin, David A; Li, Lin; Bronner, Mary P; Brentnall, Teresa A; Rabinovitch, Peter S; Horwitz, Marshall S; Loeb, Lawrence A.

Proc Natl Acad Sci U S A ; 106(49): 20871-6, 2009 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-19926851

17.

Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.

Salipante, Stephen J; Mealiffe, Matthew E; Wechsler, Jeremy; Krem, Maxwell M; Liu, Yajuan; Namkoong, Shinae; Bhagat, Govind; Kirchhoff, Tomas; Offit, Kenneth; Lynch, Henry; Wiernik, Peter H; Roshal, Mikhail; McMaster, Mary Lou; Tucker, Margaret; Fromm, Jonathan R; Goldin, Lynn R; Horwitz, Marshall S.

Proc Natl Acad Sci U S A ; 106(35): 14920-5, 2009 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-19706467

18.

Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.

Salk, Jesse J; Horwitz, Marshall S.

Semin Cancer Biol ; 20(5): 294-303, 2010 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-20951806

19.

Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development.

Anderson, Donovan J; Pauler, Florian M; McKenna, Aaron; Shendure, Jay; Hippenmeyer, Simon; Horwitz, Marshall S.

Cell Syst ; 13(6): 438-453.e5, 2022 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-35452605

20.

GATA2 deficiency: flesh and blood.

Horwitz, Marshall S.

Blood ; 123(6): 799-800, 2014 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-24505062

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