RESUMO
In order to illustrate epidemiologic features and survival rate, 31 Wilm's tumours treated in our institution have been retrospectively studied. The mean age at diagnosis in our series was surprisingly higher than usually described: 25% of the patients were older than 8 years. Moreover, a mesoblastic nephroma congenital kidney tumour--appeared in a 10 month old girl. Symptoms were usually abdominal mass or gross hematuria. Young children are often brought to medical attention because of abdominal swelling: a large flank mass was palpable in all children under 5 years. Our study shows that preoperative chemotherapy results in a less intensive treatment regimen conducting probably to less sequellae. Event free survival and overall survival were respectively 87% and 94% at 10 years after diagnosis. Renal insufficiency was the most important side effect: 2 children required renal transplantation.
Assuntos
Neoplasias Renais/diagnóstico , Neoplasias Renais/terapia , Dor Abdominal/etiologia , Adolescente , Quimioterapia Adjuvante , Criança , Pré-Escolar , Feminino , Hematúria/etiologia , Humanos , Lactente , Recém-Nascido , Neoplasias Renais/mortalidade , Masculino , Nefrectomia , Radioterapia Adjuvante , Estudos RetrospectivosRESUMO
Improved survival of pediatric cancer patients will lead to an increase of late sequellae such as secondary malignant neoplasms (SMN). Specific pediatric factors predisposing to these SMN are as follows: long expecting duration of life, high cellular proliferative potential, toxicity of often combined cancer therapies (radio- and chemotherapies) and more frequent genetic predisposition to cancer. Better understanding of these factors could improve patients management and could lead to the development of less toxic future therapies with the hope to decrease the risk of SMN.
Assuntos
Segunda Neoplasia Primária/patologia , Segunda Neoplasia Primária/terapia , Quimioterapia Adjuvante , Criança , Predisposição Genética para Doença , Humanos , Segunda Neoplasia Primária/genética , Radioterapia Adjuvante , Fatores de RiscoRESUMO
We report our experience over the last seventeen years (1985-2002) of the treatment of acute lymphoblastic leukemia (ALL) in children at the University of Liege Pediatric Department of Hematogy-Oncology (CHU-Sart Tilman and CHR-Citadelle). Seventy seven children are enrolled in our study; the mean follow-up is 6.7 years. The 5 years over all survival and the disease free survival for the entire group are respectively 83% and 79%. Prognostic factors shown in our study are sex, high white blood cells counts at diagnosis and immunophenotypes.
Assuntos
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Lactente , Masculino , Estudos Retrospectivos , Falha de TratamentoRESUMO
In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions.
Assuntos
Neuroblastoma/diagnóstico , Neuroblastoma/terapia , Neoplasias Abdominais/diagnóstico , Neoplasias Abdominais/genética , Neoplasias Abdominais/terapia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Neuroblastoma/genética , Estudos Retrospectivos , Neoplasias Torácicas/diagnóstico , Neoplasias Torácicas/genética , Neoplasias Torácicas/terapiaRESUMO
We describe the medical history and diagnostic difficulties in a 14 year-old boy who presented with "polyarthralgias".