Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.

Sortilin-related receptor 1 (SorL1) deficiency is a genetic predisposition to familial Alzheimer's disease (AD), but its pathology is poorly understood. In SorL1-null rats, a disorder of the global endosome-lysosome network (ELN) is found in hippocampal neurons. Deletion of amyloid precursor protein (APP) in SorL1-null rats could not completely rescue the neuronal abnormalities in the ELN of the hippocampus and the impairment of spatial memory in SorL1-null young rats. These in vivo observations indicated that APP is one of the cargoes of SorL1 in the regulation of the ELN, which affects hippocampal-dependent memory. When SorL1 is depleted, the endolysosome takes up more of the lysosome flux and damages lysosomal digestion, leading to pathological lysosomal storage and disturbance of cholesterol and iron homeostasis in the hippocampus. These disturbances disrupt the original homeostasis of the material-energy-subcellular structure and reprogram energy metabolism based on fatty acids in the SorL1-null hippocampus, instead of glucose. Although fatty acid oxidation increases ATP supply, it cannot reduce the levels of the harmful byproduct ROS during oxidative phosphorylation, as it does in glucose catabolism. Therefore, the SorL1-null rats exhibit hippocampal degeneration, and their spatial memory is impaired. Our research sheds light on the pathology of SorL1 deficiency in AD.

Comprehensive evaluation of carbon sequestration potential of landscape tree species and its influencing factors analysis: implications for urban green space management.

BACKGROUND: Continuous increasing carbon dioxide (CO2) has aggravated global warming and promoted urban tree planting projects for many countries. So it's imperative to select high carbon sequestering landscape tree species while considering their aesthetic values of urban green space. RESULTS: 32 tree species were selected as test objects which were commonly used in landscaping in Zhengzhou, a typical northern city of China. To assess the comprehensive carbon sequestration potential of landscape tree species in different plant configuration types, we simultaneously considered their daily net carbon sequestration per unit leaf area (wCO2), daily net carbon sequestration per unit land area (WCO2) and daily net carbon sequestration of the whole plant (QCO2) through cluster analysis. Besides that, we found out the key factors affecting carbon sequestration potential of landscape tree species by redundancy analysis. CONCLUSION: Populus, P Stenoptera, P. acerifolia among large arbors (LA), V odoratissimum, P. Serratifolia, S. oblata among small arbors (SA), and B sinica var. Parvifolia, B. Megistophylla, L quihoui among shrubs (S) were recommended for local urban green space management. Photosynthetic rate (Pn), crown area (CA) and leaf area index (LAI) were the key factors which affected the comprehensive carbon sequestration potential both for LA, SA and S.

Evaluation of soil and water conservation function in the Wugong mountain meadow based on the comprehensive index method.

Wugong Mountain meadow landscape is well-known both at home and abroad because of its ornamental value. Our study aimed to comprehensively evaluate the function of soil and water conservation at different altitudes of Wugong Mountain meadow soil. The hydro-physical characteristics, including the soil bulk density, porosity, water content, water holding capacity, and permeability of meadow soil at 1600 m-1900 m altitudes, were analyzed. The results showed that the mountain meadow soil's hydro-physiological characteristics and water conservation function significantly differed with altitude. However, the trend of each index did not follow the same law with altitude change. There was a decrease in bulk density of the soil from 1700 m to 1900 m, but a significant increase in porosity and water-holding capacity. Despite the higher porosity and water holding capacity found at 1600 m than at 1700 m and 1800 m, a similar bulk density was found at 1600 m as 1700 m. In addition, the bulk density in the 0-20 cm layer was lower than that in the 20-40 cm layer, while the porosity and water-holding capacity were higher. A higher sequence of soil water conservation capacity was found in soil layers 0-20 cm depth at 1900, 1600, 1800, and 1700 m; in soil layers 20-40 cm depth, it was at 1900, 1800, 1700, and 1600 m. The study found that the sequence of the comprehensive performance of soil water conservation function was at 1900, 1600, 1800, and 1700 m altitudes in the Wugong mountain meadow area. Our comprehensive study of soil water conservation capacity provides a theoretical basis for the rational use of mountain meadow resources in subtropical regions.

Trends in the global burden of oral cancer joint with attributable risk factors: Results from the global burden of disease study 2019.

OBJECTIVES: To investigate the characteristics of risk factors for oral cancer and the disease burden they caused. MATERIALS AND METHODS: Data from GBD2019, where the EAPC was calculated to understand mortality trends and the APC model was used for the analysis of age characteristics. RESULTS: Overall oral cancer mortality showed a promising downward trend [EAPC = -0.05 (-0.08 to -0.02)]. Oral cancer mortality attributable to tobacco chewing alone showed a significant upward trend [EAPC = 0.44 (0.36-0.52)]. Males are the majority of oral cancer deaths, while the disease burden of oral cancer in females could be largely attributable to chewing tobacco. The age of death attributable to each risk factor for oral cancer is concentrated between 45 and 74 years. Mortality for oral cancer caused by alcohol and smokeless tobacco was increasing in younger age groups (age < 45), and this trend was more pronounced in middle and middle-high SDI areas. The disease burden of oral cancer in high SDI regions was mainly attributed to alcohol consumption, while in middle and lower SDI regions it was mainly attributed to tobacco. CONCLUSION: Smokeless tobacco proved a critical factor in the significant regional distribution of oral cancer. Oral cancer is on the increase in younger age groups. According to the characteristics of the distribution of risk factors, in traditionally high-incidence regions, such as India and Pakistan, oral cancer kept the highest ASDR, but was not experiencing the fastest growth rate. Additionally, it was oral cancer in middle SDI regions that needs more attention.