Pesquisa | BVS Violência e Saúde

1.

Artemisinins Target GABA_A Receptor Signaling and Impair α Cell Identity.

Li, Jin; Casteels, Tamara; Frogne, Thomas; Ingvorsen, Camilla; Honoré, Christian; Courtney, Monica; Huber, Kilian V M; Schmitner, Nicole; Kimmel, Robin A; Romanov, Roman A; Sturtzel, Caterina; Lardeau, Charles-Hugues; Klughammer, Johanna; Farlik, Matthias; Sdelci, Sara; Vieira, Andhira; Avolio, Fabio; Briand, François; Baburin, Igor; Májek, Peter; Pauler, Florian M; Penz, Thomas; Stukalov, Alexey; Gridling, Manuela; Parapatics, Katja; Barbieux, Charlotte; Berishvili, Ekaterine; Spittler, Andreas; Colinge, Jacques; Bennett, Keiryn L; Hering, Steffen; Sulpice, Thierry; Bock, Christoph; Distel, Martin; Harkany, Tibor; Meyer, Dirk; Superti-Furga, Giulio; Collombat, Patrick; Hecksher-Sørensen, Jacob; Kubicek, Stefan.

Cell ; 168(1-2): 86-100.e15, 2017 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-27916275

2.

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

Martins, Rui; Maier, Julia; Gorki, Anna-Dorothea; Huber, Kilian V M; Sharif, Omar; Starkl, Philipp; Saluzzo, Simona; Quattrone, Federica; Gawish, Riem; Lakovits, Karin; Aichinger, Michael C; Radic-Sarikas, Branka; Lardeau, Charles-Hugues; Hladik, Anastasiya; Korosec, Ana; Brown, Markus; Vaahtomeri, Kari; Duggan, Michelle; Kerjaschki, Dontscho; Esterbauer, Harald; Colinge, Jacques; Eisenbarth, Stephanie C; Decker, Thomas; Bennett, Keiryn L; Kubicek, Stefan; Sixt, Michael; Superti-Furga, Giulio; Knapp, Sylvia.

Nat Immunol ; 17(12): 1361-1372, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27798618

3.

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Raux, Brigitt; Buchan, Karly A; Bennett, James; Christott, Thomas; Dowling, Matthew S; Farnie, Gillian; Fedorov, Oleg; Gamble, Vicki; Gileadi, Carina; Giroud, Charline; Huber, Kilian V M; Korczynska, Magdalena; Limberakis, Chris; Narayanan, Arjun; Owen, Dafydd R; Sáez, Laura Díaz; Stock, Ingrid A; Londregan, Allyn T.

Bioorg Med Chem Lett ; 98: 129546, 2024 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-37944866

4.

Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.

Rothweiler, Elisabeth M; Brennan, Paul E; Huber, Kilian V M.

Biol Chem ; 403(4): 391-402, 2022 03 28.

Artigo em Inglês | MEDLINE | ID: mdl-35191283

5.

Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity.

Martin, Jeffrey G; Ward, Jennifer A; Feyertag, Felix; Zhang, Lu; Couvertier, Shalise; Guckian, Kevin; Huber, Kilian V M; Johnson, Douglas S.

Chembiochem ; 22(12): 2116-2123, 2021 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-33887086

6.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Böttcher, Jark; Dilworth, David; Reiser, Ulrich; Neumüller, Ralph A; Schleicher, Michael; Petronczki, Mark; Zeeb, Markus; Mischerikow, Nikolai; Allali-Hassani, Abdellah; Szewczyk, Magdalena M; Li, Fengling; Kennedy, Steven; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Brown, Peter J; Huber, Kilian V M; Rogers, Catherine M; Wells, Carrow I; Fedorov, Oleg; Rumpel, Klaus; Zoephel, Andreas; Mayer, Moriz; Wunberg, Tobias; Böse, Dietrich; Zahn, Stephan; Arnhof, Heribert; Berger, Helmut; Reiser, Christoph; Hörmann, Alexandra; Krammer, Teresa; Corcokovic, Maja; Sharps, Bernadette; Winkler, Sandra; Häring, Daniela; Cockcroft, Xiao-Ling; Fuchs, Julian E; Müllauer, Barbara; Weiss-Puxbaum, Alexander; Gerstberger, Thomas; Boehmelt, Guido; Vakoc, Christopher R; Arrowsmith, Cheryl H; Pearson, Mark; McConnell, Darryl B.

Nat Chem Biol ; 15(8): 822-829, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31285596

7.

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

Rebsamen, Manuele; Pochini, Lorena; Stasyk, Taras; de Araújo, Mariana E G; Galluccio, Michele; Kandasamy, Richard K; Snijder, Berend; Fauster, Astrid; Rudashevskaya, Elena L; Bruckner, Manuela; Scorzoni, Stefania; Filipek, Przemyslaw A; Huber, Kilian V M; Bigenzahn, Johannes W; Heinz, Leonhard X; Kraft, Claudine; Bennett, Keiryn L; Indiveri, Cesare; Huber, Lukas A; Superti-Furga, Giulio.

Nature ; 519(7544): 477-81, 2015 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-25561175

8.

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

Huber, Kilian V M; Salah, Eidarus; Radic, Branka; Gridling, Manuela; Elkins, Jonathan M; Stukalov, Alexey; Jemth, Ann-Sofie; Göktürk, Camilla; Sanjiv, Kumar; Strömberg, Kia; Pham, Therese; Berglund, Ulrika Warpman; Colinge, Jacques; Bennett, Keiryn L; Loizou, Joanna I; Helleday, Thomas; Knapp, Stefan; Superti-Furga, Giulio.

Nature ; 508(7495): 222-7, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24695225

9.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick, Efrat; Bradley, Anthony; Gan, Jinrui; Douangamath, Alice; Krojer, Tobias; Sethi, Ritika; Geurink, Paul P; Aimon, Anthony; Amitai, Gabriel; Bellini, Dom; Bennett, James; Fairhead, Michael; Fedorov, Oleg; Gabizon, Ronen; Gan, Jin; Guo, Jingxu; Plotnikov, Alexander; Reznik, Nava; Ruda, Gian Filippo; Díaz-Sáez, Laura; Straub, Verena M; Szommer, Tamas; Velupillai, Srikannathasan; Zaidman, Daniel; Zhang, Yanling; Coker, Alun R; Dowson, Christopher G; Barr, Haim M; Wang, Chu; Huber, Kilian V M; Brennan, Paul E; Ovaa, Huib; von Delft, Frank; London, Nir.

J Am Chem Soc ; 141(22): 8951-8968, 2019 06 05.

Artigo em Inglês | MEDLINE | ID: mdl-31060360

10.

Global survey of the immunomodulatory potential of common drugs.

Vladimer, Gregory I; Snijder, Berend; Krall, Nikolaus; Bigenzahn, Johannes W; Huber, Kilian V M; Lardeau, Charles-Hugues; Sanjiv, Kumar; Ringler, Anna; Berglund, Ulrika Warpman; Sabler, Monika; de la Fuente, Oscar Lopez; Knöbl, Paul; Kubicek, Stefan; Helleday, Thomas; Jäger, Ulrich; Superti-Furga, Giulio.

Nat Chem Biol ; 13(6): 681-690, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28437395

11.

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.

Vazquez-Rodriguez, Saleta; Wright, Miranda; Rogers, Catherine M; Cribbs, Adam P; Velupillai, Srikannathasan; Philpott, Martin; Lee, Henry; Dunford, James E; Huber, Kilian V M; Robers, Matthew B; Vasta, James D; Thezenas, Marie-Laetitia; Bonham, Sarah; Kessler, Benedikt; Bennett, James; Fedorov, Oleg; Raynaud, Florence; Donovan, Adam; Blagg, Julian; Bavetsias, Vassilios; Oppermann, Udo; Bountra, Chas; Kawamura, Akane; Brennan, Paul E.

Angew Chem Int Ed Engl ; 58(2): 515-519, 2019 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-30431220

12.

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

Huber, Kilian V M; Olek, Karin M; Müller, André C; Tan, Chris Soon Heng; Bennett, Keiryn L; Colinge, Jacques; Superti-Furga, Giulio.

Nat Methods ; 12(11): 1055-7, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26389571

13.

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

Sdelci, Sara; Lardeau, Charles-Hugues; Tallant, Cynthia; Klepsch, Freya; Klaiber, Björn; Bennett, James; Rathert, Philipp; Schuster, Michael; Penz, Thomas; Fedorov, Oleg; Superti-Furga, Giulio; Bock, Christoph; Zuber, Johannes; Huber, Kilian V M; Knapp, Stefan; Müller, Susanne; Kubicek, Stefan.

Nat Chem Biol ; 12(7): 504-10, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27159579

14.

Discovery of an MLLT1/3 YEATS Domain Chemical Probe.

Moustakim, Moses; Christott, Thomas; Monteiro, Octovia P; Bennett, James; Giroud, Charline; Ward, Jennifer; Rogers, Catherine M; Smith, Paul; Panagakou, Ioanna; Díaz-Sáez, Laura; Felce, Suet Ling; Gamble, Vicki; Gileadi, Carina; Halidi, Nadia; Heidenreich, David; Chaikuad, Apirat; Knapp, Stefan; Huber, Kilian V M; Farnie, Gillian; Heer, Jag; Manevski, Nenad; Poda, Gennady; Al-Awar, Rima; Dixon, Darren J; Brennan, Paul E; Fedorov, Oleg.

Angew Chem Int Ed Engl ; 57(50): 16302-16307, 2018 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-30288907

15.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

Grebien, Florian; Vedadi, Masoud; Getlik, Matthäus; Giambruno, Roberto; Grover, Amit; Avellino, Roberto; Skucha, Anna; Vittori, Sarah; Kuznetsova, Ekaterina; Smil, David; Barsyte-Lovejoy, Dalia; Li, Fengling; Poda, Gennadiy; Schapira, Matthieu; Wu, Hong; Dong, Aiping; Senisterra, Guillermo; Stukalov, Alexey; Huber, Kilian V M; Schönegger, Andreas; Marcellus, Richard; Bilban, Martin; Bock, Christoph; Brown, Peter J; Zuber, Johannes; Bennett, Keiryn L; Al-Awar, Rima; Delwel, Ruud; Nerlov, Claus; Arrowsmith, Cheryl H; Superti-Furga, Giulio.

Nat Chem Biol ; 11(8): 571-578, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26167872

16.

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

Bataille, Carole J R; Brennan, Méabh B; Byrne, Simon; Davies, Stephen G; Durbin, Matthew; Fedorov, Oleg; Huber, Kilian V M; Jones, Alan M; Knapp, Stefan; Liu, Gu; Nadali, Anna; Quevedo, Camilo E; Russell, Angela J; Walker, Roderick G; Westwood, Robert; Wynne, Graham M.

Bioorg Med Chem ; 25(9): 2657-2665, 2017 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-28341403

17.

Discovery of a PCAF Bromodomain Chemical Probe.

Moustakim, Moses; Clark, Peter G K; Trulli, Laura; Fuentes de Arriba, Angel L; Ehebauer, Matthias T; Chaikuad, Apirat; Murphy, Emma J; Mendez-Johnson, Jacqui; Daniels, Danette; Hou, Chun-Feng D; Lin, Yu-Hui; Walker, John R; Hui, Raymond; Yang, Hongbing; Dorrell, Lucy; Rogers, Catherine M; Monteiro, Octovia P; Fedorov, Oleg; Huber, Kilian V M; Knapp, Stefan; Heer, Jag; Dixon, Darren J; Brennan, Paul E.

Angew Chem Int Ed Engl ; 56(3): 827-831, 2017 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-27966810

18.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

Winter, Georg E; Radic, Branka; Mayor-Ruiz, Cristina; Blomen, Vincent A; Trefzer, Claudia; Kandasamy, Richard K; Huber, Kilian V M; Gridling, Manuela; Chen, Doris; Klampfl, Thorsten; Kralovics, Robert; Kubicek, Stefan; Fernandez-Capetillo, Oscar; Brummelkamp, Thijn R; Superti-Furga, Giulio.

Nat Chem Biol ; 10(9): 768-773, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25064833

19.

Target engagement: Shining a light.

Huber, Kilian V M.

Nat Chem Biol ; 13(2): 133-134, 2017 01 19.

Artigo em Inglês | MEDLINE | ID: mdl-28103226

20.

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Balikçi, Esra; Marques, Anne-Sophie M C; Bauer, Ludwig G; Seupel, Raina; Bennett, James; Raux, Brigitt; Buchan, Karly; Simelis, Klemensas; Singh, Usha; Rogers, Catherine; Ward, Jennifer; Cheng, Carol; Szommer, Tamas; Schützenhofer, Kira; Elkins, Jonathan M; Sloman, David L; Ahel, Ivan; Fedorov, Oleg; Brennan, Paul E; Huber, Kilian V M.

J Med Chem ; 67(9): 7245-7259, 2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38635563

BVS Violência e Saúde

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: