Detalhe da pesquisa
1.
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Proc Natl Acad Sci U S A
; 110(16): E1533-42, 2013 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23509299
2.
Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.
J Biol Chem
; 285(44): 33614-22, 2010 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20732872
3.
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Proc Natl Acad Sci U S A
; 105(35): 12791-6, 2008 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18728186
4.
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
Biochem J
; 394(Pt 2): 427-35, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16356165
5.
Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.
J Clin Invest
; 127(4): 1438-1450, 2017 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28263187
6.
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Circ Res
; 95(1): 67-75, 2004 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15178638
7.
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
Cell Signal
; 17(9): 1158-73, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15905070
8.
In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.
Cell Signal
; 14(5): 453-65, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11882390
9.
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
Cell Signal
; 15(10): 955-71, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12873709
10.
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
Biochem J
; 380(Pt 2): 371-84, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15025561
11.
Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.
Cell Signal
; 26(9): 1958-74, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24815749
12.
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
J Med Chem
; 54(9): 3331-47, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21456625
13.
Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.
Mol Cell Biol
; 30(22): 5406-20, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20837708
14.
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
Mol Cell Biol
; 30(18): 4379-90, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20647544
15.
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
J Biol Chem
; 284(17): 11425-35, 2009 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19153083
16.
Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.
J Cell Sci
; 119(Pt 18): 3799-810, 2006 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16940352
17.
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
Mol Pharmacol
; 67(6): 1920-34, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15738310
18.
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science
; 310(5751): 1187-91, 2005 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16293762
19.
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
J Biol Chem
; 278(49): 49230-8, 2003 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-14500724
20.
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
J Biol Chem
; 278(35): 33351-63, 2003 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12810716