Detalhe da pesquisa
1.
Enhanced in-Source Fragmentation Annotation Enables Novel Data Independent Acquisition and Autonomous METLIN Molecular Identification.
Anal Chem
; 92(8): 6051-6059, 2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32242660
2.
Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.
Bioorg Med Chem Lett
; 20(14): 4027-31, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20610151
3.
Acoustic Droplet Ejection and Open Port Interface for Rapid Analysis of Metabolic Stability Assays.
J Pharm Sci
; 109(11): 3285-3291, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32745563
4.
Cell-based optimization of novel benzamides as potential antimalarial leads.
Bioorg Med Chem Lett
; 19(24): 6970-4, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19879133
5.
Plasma Protein Binding of Highly Bound Drugs Determined With Equilibrium Gel Filtration of Nonradiolabeled Compounds and LC-MS/MS Detection.
J Pharm Sci
; 108(2): 1053-1060, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30336155
6.
Snapshot PK: a rapid rodent in vivo preclinical screening approach.
Drug Discov Today
; 13(7-8): 360-7, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18405850
7.
Cherry-picking in an orchard: unattended LC/MS analysis from an autosampler with >32,000 samples online.
J Biomol Screen
; 11(3): 318-22, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16490775
8.
Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries.
J Biomol Screen
; 11(8): 933-9, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17092919
9.
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J Med Chem
; 59(14): 6671-89, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27433829
10.
A novel method for immediate post-purification purity determination of fractions collected during high-throughput purification.
J Chromatogr A
; 1092(2): 228-34, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16199230
11.
Putative domal microbial structures in fluvial siliciclastic facies of the Mesoproterozoic (1.09 Ga) Copper Harbor Conglomerate, Upper Peninsula of Michigan, USA.
Geobiology
; 12(1): 99-108, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24325309
12.
Changing requirements of purification as drug discovery programs evolve from hit discovery.
J Comb Chem
; 10(2): 150-7, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18181578
13.
A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery.
Drug Discov Today
; 18(1-2): 71-8, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22982770
14.
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
J Med Chem
; 55(9): 4244-73, 2012 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524250
15.
Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
J Med Chem
; 54(14): 5116-30, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21644570
16.
Interstrain differences of in vitro metabolic stability and impact on early drug discovery.
J Pharm Sci
; 99(11): 4463-8, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20845445
17.
CO2-forced climate and vegetation instability during Late Paleozoic deglaciation.
Science
; 315(5808): 87-91, 2007 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17204648
18.
Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening.
J Comb Chem
; 7(2): 210-7, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15762748
19.
High-throughput mass-directed parallel purification incorporating a multiplexed single quadrupole mass spectrometer.
Anal Chem
; 74(13): 3055-62, 2002 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12141664