Detalhe da pesquisa
1.
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg Med Chem
; 25(7): 2133-2147, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284870
2.
T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production.
Biochem Biophys Res Commun
; 479(2): 179-185, 2016 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27608596
3.
An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
Biochem Biophys Res Commun
; 480(3): 380-386, 2016 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27771247
4.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476141
5.
Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist.
Chem Pharm Bull (Tokyo)
; 63(11): 858-65, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26521850
6.
Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.
Bioorg Med Chem
; 21(8): 2250-2261, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23490150
7.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23816042
8.
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg Med Chem
; 21(18): 5725-37, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23928071
9.
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
Bioorg Med Chem
; 21(24): 7938-54, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169315
10.
Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
J Biol Chem
; 286(21): 18756-65, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454582
11.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22883026
12.
Design and synthesis of pyrrolo[3,2-d]pyrimidine HER2/EGFR dual inhibitors: improvement of the physicochemical and pharmacokinetic profiles for potent in vivo anti-tumor efficacy.
Bioorg Med Chem
; 20(20): 6171-80, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22980219
13.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22763369
14.
(+)-Phorboxazole A synthetic studies. A highly convergent, second generation total synthesis of (+)-phorboxazole A.
Org Lett
; 7(20): 4399-402, 2005 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16178543
15.
Synthetic Studies on Centromere-Associated Protein-E (CENP-E) Inhibitors: 2. Application of Electrostatic Potential Map (EPM) and Structure-Based Modeling to Imidazo[1,2-a]pyridine Derivatives as Anti-Tumor Agents.
J Med Chem
; 58(20): 8036-53, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372373
16.
Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells.
Nat Commun
; 6: 7668, 2015 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26144554
17.
HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285.
Oncoscience
; 1(3): 196-204, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25594012
18.
Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.
Cancer Res
; 73(23): 7043-55, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24121489
19.
Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model.
J Cancer
; 4(7): 557-65, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23983820
20.
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
ACS Med Chem Lett
; 4(2): 201-5, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900643