[The role of interval hypoxytherapy and enteral oxygen therapy in the rehabilitation of the patients presenting with chronic obstructive pulmonary disease]. / Interval'naia gipoksiterapiia i énteral'naia oksigenoterapiia v reabilitatsii patsientov s khronicheskoi obstruktivnoi bolezn'iu legkikh.

BACKGROUND: The efficiency of the application of normobaric interval hypoxic therapy and enteral oxygen therapy for the treatment of the patients suffering from chronic obstructive pulmonary disease remains to be confirmed. AIM: The objective of the present study was the identification of the pathophysiological mechanisms responsible for the efficiency of normobaric interval hypoxic therapy and enteral oxygen therapy in the patients presenting with a chronic obstructive pulmonary disease. MATERIAL AND METHODS: A total of 230 patients at the age from 45 to 60 years were examined. All of them presented with chronic obstructive pulmonary disease (COPD). 150 patients were given a course of normobaric interval hypoxic therapy and enteral oxygen therapy while the remaining 80 ones constituted the control group. RESULTS: It was shown that the combined application of normobaric interval hypoxic therapy and enteral oxygen therapy provided an effective tool for the correction of the health status in the patients with chronic obstructive pulmonary disease. This method allowed to improve arterial blood supply with oxygen, increase the blood hemoglobin level and its oxygen capacity, augment oxygen tension and content in the arterial blood. The combination of the intake of oxygen cocktails and hypoxic therapy resulted in the improvement of metabolic processes in the lungs manifested as the alteration in the characteristics of the condensate of the exhaled air. The decrease in the content of malondialdehyde gave evidence of the reduction of lipid peroxidation while the enhanced activities of glutathione peroxidase and superoxide dismutase in blood confirmed the activation of the antioxidant system. The improved oxygen supply at all stages of its mass transfer along with the resulting improvement of oxygen utilization by the tissues was responsible for the reduction of hypoxia in the bronchial tree and lung tissue. CONCLUSION: The present study confirmed the high effectiveness of the combined application of normobaric interval hypoxic therapy and enteral oxygen therapy for the rehabilitation of the patients presenting with chronic obstructive pulmonary disease.

[The application of normobaric hypoxytherapy for the subclinical hypothyroidism].

UNLABELLED: At present, there is no uniform approach to the treatment of subclinical hypothyroidism (SH). The objective of the present study was to estimate the influence of normobaric hypoxytherapy on the thyroid status and immunological characteristics of the patients presenting with subclinical hypothyroidism. MATERIAL AND METHODS: The study involved 140 patients at the age varying from 18 to 60 years suffering from SH associated with autoimmune thyroiditis: 75 of them underwent a course of hypoxytherapy, the remaining 65 patients comprised the control group. RESULTS: The changes in the immune status of the patients with SH were apparent as the depression of cellular immunity and activation of humoral immunity which confirmed the autoimmune nature of the disease. Hypoxytherapy caused positive changes in the immune status of the patients in the form of increased number of CD3+ and CD(8+)-cells, reduction of the number of CD(4+)-cells, and the normalization of the immunoregulatory index. The evaluation of the parameters of humoral immunity has demonstrated normalization of the total B-lymphocyte content along with the level of serum IgA, IgM, IgG, reduction of circulating immune complexes and anti-thyroid antibodies. These changes promoted the recovery of the thyroid function that manifested itself as the normalization of the blood thyroid-stimulating hormone level. CONCLUSION: It is concluded that hypoxytherapy can be recommended as monotherapy for the treatment of subclinical hypothyroidism as a tool for the influence on the key components of pathogenesis of this disease and prevention of the manifestation of its clinically expressed form.

The global topography of Mars and implications for surface evolution.

Elevations measured by the Mars Orbiter Laser Altimeter have yielded a high-accuracy global map of the topography of Mars. Dominant features include the low northern hemisphere, the Tharsis province, and the Hellas impact basin. The northern hemisphere depression is primarily a long-wavelength effect that has been shaped by an internal mechanism. The topography of Tharsis consists of two broad rises. Material excavated from Hellas contributes to the high elevation of the southern hemisphere and to the scarp along the hemispheric boundary. The present topography has three major drainage centers, with the northern lowlands being the largest. The two polar cap volumes yield an upper limit of the present surface water inventory of 3.2 to 4.7 million cubic kilometers.

Observations of the north polar region of Mars from the Mars orbiter laser altimeter.

Elevations from the Mars Orbiter Laser Altimeter (MOLA) have been used to construct a precise topographic map of the martian north polar region. The northern ice cap has a maximum elevation of 3 kilometers above its surroundings but lies within a 5-kilometer-deep hemispheric depression that is contiguous with the area into which most outflow channels emptied. Polar cap topography displays evidence of modification by ablation, flow, and wind and is consistent with a primarily H2O composition. Correlation of topography with images suggests that the cap was more spatially extensive in the past. The cap volume of 1.2 x 10(6) to 1.7 x 10(6) cubic kilometers is about half that of the Greenland ice cap. Clouds observed over the polar cap are likely composed of CO2 that condensed out of the atmosphere during northern hemisphere winter. Many clouds exhibit dynamical structure likely caused by the interaction of propagating wave fronts with surface topography.

[Effect of 12-hydroxy-9(Z)-dodecenoic acid on growth and cell division in pea roots]. / Vliianie 12-gidroksi-9(Z)-dodetsenovoi kisloty na rost i delenie kletok korne gorokha.

It is known that potential bioregulators may be present among lipoxygenase oxidation products. A possibility of mitotic cycle regulation by 12-hydroxy-9(Z)-dodecenic acid (12-HDA) and also its influence on the growing function (seed germination, root and epicotyl growth) have been studied. It has been determined that 12-HDA activity is directed to the strengthening of growing function which allowed to suppose that oxylipin is capable of regulating cell division. 12-HDA participation in the mitotic cycle regulation were determined by the originally developed test system using simultaneously light microscopy. The concentration and temporal dependencies of cell division were studied under the influence of 12-HDA. The raise of mitosis (up to 17.5 times) has been registered in comparison with the control variant by the least concentration of 12-HDA (10(-9) M) up to the 4th h of influence, confirming oxypilin participation in mitotic cycle regulation.

Reduction of phase thickness is a characteristic reaction of the nucleoli to toxicity as shown by coherent phase microscopy.

Optical parameters of human cell nucleoli (HCT116 colorectal cancer cells) in depolymerization of microtubules and depletion of intracellular ATP pool were studied by coherent phase microscopy. These influences were associated with a rapid (recorded within the first minutes) reduction of the phase thickness of the nucleoli. These changes are similar to the nucleolar response to direct inhibitors of transcription. Hence, quantitative parameters of coherent phase microscopy describe common reaction of the nucleolus to stress; reduction of optical thickness of the nucleolus is a component of this reaction.