Detalhe da pesquisa
1.
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Bioorg Med Chem
; 71: 116947, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926325
2.
Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile.
Bioorg Med Chem Lett
; 30(17): 127405, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738982
3.
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Nature
; 513(7516): 124-7, 2014 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043059
4.
A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin.
Nat Chem Biol
; 8(5): 477-85, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22466420
5.
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
J Med Chem
; 67(1): 774-781, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38156904
6.
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein.
J Med Chem
; 67(6): 4936-4949, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38477582
7.
The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.
Mol Cancer Ther
; 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641404
8.
Simulations of biased agonists in the ß(2) adrenergic receptor with accelerated molecular dynamics.
Biochemistry
; 52(33): 5593-603, 2013 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23879802
9.
Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.
Biochemistry
; 51(11): 2199-212, 2012 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352759
10.
Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.
Mol Pharmacol
; 82(6): 1042-55, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22923500
11.
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.
RSC Med Chem
; 13(12): 1549-1564, 2022 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36545438
12.
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5â¢MTA Complex for the Treatment of MTAP-Deleted Cancers.
J Med Chem
; 65(3): 1749-1766, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041419
13.
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
J Med Chem
; 65(14): 9678-9690, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35833726
14.
Predictive power of molecular dynamics receptor structures in virtual screening.
J Chem Inf Model
; 51(6): 1439-46, 2011 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21534609
15.
Coarse-grained MD simulations of membrane protein-bilayer self-assembly.
Structure
; 16(4): 621-30, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18400182
16.
Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.
Biochemistry
; 48(42): 10078-88, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19754156
17.
Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".
ACS Med Chem Lett
; 8(12): 1341, 2017 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29259759
18.
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
ACS Med Chem Lett
; 8(3): 316-320, 2017 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28337323
19.
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
J Med Chem
; 60(13): 5663-5672, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28594552
20.
Discovery of novel inhibitors of HIV-1 reverse transcriptase through virtual screening of experimental and theoretical ensembles.
Chem Biol Drug Des
; 83(5): 521-31, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405985