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1.
J Am Acad Dermatol ; 87(3): 573-581, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35551965

RESUMO

BACKGROUND: There is variation in the outcomes reported in clinical studies of basal cell carcinoma. This can prevent effective meta-analyses from answering important clinical questions. OBJECTIVE: To identify a recommended minimum set of core outcomes for basal cell carcinoma clinical trials. METHODS: Patient and professional Delphi process to cull a long list, culminating in a consensus meeting. To be provisionally accepted, outcomes needed to be deemed important (score, 7-9, with 9 being the maximum) by 70% of each stakeholder group. RESULTS: Two hundred thirty-five candidate outcomes identified via a systematic literature review and survey of key stakeholders were reduced to 74 that were rated by 100 health care professionals and patients in 2 Delphi rounds. Twenty-seven outcomes were provisionally accepted. The final core set of 5 agreed-upon outcomes after the consensus meeting included complete response; persistent or serious adverse events; recurrence-free survival; quality of life; and patient satisfaction, including cosmetic outcome. LIMITATIONS: English-speaking patients and professionals rated outcomes extracted from English language studies. CONCLUSION: A core outcome set for basal cell carcinoma has been developed. The use of relevant measures may improve the utility of clinical research and the quality of therapeutic guidance available to clinicians.


Assuntos
Carcinoma Basocelular , Neoplasias Cutâneas , Carcinoma Basocelular/terapia , Técnica Delphi , Humanos , Qualidade de Vida , Projetos de Pesquisa , Neoplasias Cutâneas/terapia , Resultado do Tratamento
2.
Dermatol Surg ; 46(2): 192-201, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31743247

RESUMO

BACKGROUND: Bleeding is an unavoidable risk of dermatologic surgery. The risk may be higher in patients taking agents that affect hemostasis. OBJECTIVE: The aim of this study was to provide an updated review of current anticoagulant and antiplatelet therapy available in the market and their associated risk of bleeding complications in cutaneous surgery. MATERIALS AND METHODS: A review of PubMed and MEDLINE was performed to review the English-language medical literature. RESULTS: Many anticoagulant and antiplatelet therapies exist. Several studies recommend the continued use of antiplatelet and anticoagulant medications in the perioperative period. Combination regimens and novel oral anticoagulants may be associated with an increased risk of bleeding. CONCLUSION: An updated understanding of antiplatelet and anticoagulant agents is critical for the surgeon. Current evidence does not support the discontinuation of antiplatelet and anticoagulant agents in the perioperative period under most circumstances. However, relevant data on novel oral anticoagulant agents are still sparse, suggesting that a precautionary approach is warranted.


Assuntos
Anticoagulantes/efeitos adversos , Perda Sanguínea Cirúrgica/prevenção & controle , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Inibidores da Agregação Plaquetária/efeitos adversos , Hemorragia Pós-Operatória/prevenção & controle , Fibrilação Atrial/tratamento farmacológico , Fibrilação Atrial/prevenção & controle , Humanos , Infarto do Miocárdio/tratamento farmacológico , Infarto do Miocárdio/prevenção & controle , Período Perioperatório , Hemorragia Pós-Operatória/induzido quimicamente , Embolia Pulmonar/tratamento farmacológico , Embolia Pulmonar/prevenção & controle , Acidente Vascular Cerebral/tratamento farmacológico , Trombose Venosa/tratamento farmacológico , Trombose Venosa/prevenção & controle
3.
Dermatol Surg ; 46(2): 203-212, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31592926

RESUMO

BACKGROUND: There are many intraoperative and postoperative techniques to aid hemostasis in dermatologic procedures. An updated understanding is critical for the surgeon. OBJECTIVE: To provide an updated review of methods for hemostasis and therapies for postprocedural purpura and ecchymosis applicable to dermatology. MATERIALS AND METHODS: A review of Ovid MEDLINE was performed to review the English-language medical literature of hemostatic options and their use in cutaneous surgery. All available publication years were included from 1946 to present. RESULTS: A comprehensive and current list of hemostatic options used in the intraoperative and postoperative period is provided along with traditional and emerging therapies for postprocedural purpura and ecchymosis. CONCLUSION: A myriad of options exist for minimizing and treating bleeding complications. The appropriate use and updated knowledge of hemostatic options is provided.


Assuntos
Perda Sanguínea Cirúrgica/prevenção & controle , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Técnicas Hemostáticas , Assistência Perioperatória/métodos , Complicações Pós-Operatórias/terapia , Equimose/etiologia , Equimose/terapia , Hematoma/etiologia , Hematoma/terapia , Humanos , Complicações Pós-Operatórias/etiologia , Púrpura/etiologia , Púrpura/terapia , Pele/irrigação sanguínea
4.
J Am Acad Dermatol ; 80(6): 1671-1681, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30710607

RESUMO

BACKGROUND: Although treatments to address cosmetic concerns are common, patients' self-reported motives for considering such procedures have not been systematically explored. OBJECTIVE: To develop a framework of categories to describe patients' self-reported motivations for undergoing minimally invasive cosmetic procedures. METHODS: Face-to-face, semistructured patient interviews were conducted with adult participants who had undergone or were considering minimally invasive cosmetic dermatologic procedures. A qualitative constant comparative approach was used to analyze interview transcripts, yielding themes and subthemes. RESULTS: A total of 30 interviews were completed. Most patient-reported motivations for cosmetic procedures could be subsumed under 8 general categories (themes): (1) mental and emotional health, (2) cosmetic appearance, (3) physical health, (4) work and/or school success, (5) social well-being, (6) cost and/or convenience, (7) procedural perceptions, and (8) timing of treatment. Many individual motivations in these categories were unrelated to desire for physical beauty. In particular, participants wanted to avoid being self-conscious, enhance confidence, reduce the time and expense required to conceal physical imperfections, and be perceived as capable at work. LIMITATIONS: Only English-speaking patients in the United States were interviewed. CONCLUSION: Patient-reported motivations for cosmetic procedures mostly pertained to physical and psychosocial well-being. Indeed, a desire for improved cosmetic appearance was only 1 of the 8 themes revealed through the patient interviews.


Assuntos
Técnicas Cosméticas/psicologia , Procedimentos Cirúrgicos Minimamente Invasivos/psicologia , Motivação , Pacientes/psicologia , Adulto , Imagem Corporal , Técnicas Cosméticas/economia , Emoções , Feminino , Humanos , Relações Interpessoais , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/economia , Pesquisa Qualitativa , Qualidade de Vida , Fatores Socioeconômicos
6.
Lasers Med Sci ; 34(4): 703-709, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30280300

RESUMO

Non-invasive skin-tightening devices can induce thermal denaturation and skin shrinkage via externally applied radiofrequency emissions or high-frequency ultrasound. Therefore, the purpose of this study is to develop and test a method for measurement of skin reduction associated with application of such energy devices. Twenty-five healthy participants with mild to moderate skin laxity of the arms were enrolled. Pinpoint microtattoos were placed at each of the treatment sites to delineate two 6 × 12 cm rectangles per subject. A non-stretchable filament, tape and marking pen apparatus was used to measure the size of each rectangle before treatment and at follow-up visit by two blinded investigators. After randomization, one side received a single pass with a radiofrequency device (6.78 MHz), while the contralateral side received multiple passes. Participants underwent two treatment sessions to each side 2 weeks apart, and returned for follow-up 4 weeks after the second treatment. Length and area measurement were analyzed to assess precision and accuracy of measurements and to compare efficacy of treatment between pre- and post-treatment. Concordance correlation coefficients (CCC) demonstrated substantial inter-investigator reliability and precision in length measurements (CCC, 0.94 to 0.98 in pre-treatment; 0.95 to 0.98 in post-treatment). Measurements at the 6-week post-treatment follow-up demonstrated a statistically significant skin reduction in all six of the measured parameters. A simple skin measurement method requiring minimal instrumentation can quantitatively evaluate skin shrinkage associated with non-invasive skin-tightening devices.


Assuntos
Envelhecimento da Pele/patologia , Pele/patologia , Tatuagem , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Ondas de Rádio , Reprodutibilidade dos Testes , Resultado do Tratamento
7.
Lasers Surg Med ; 50(2): 96-110, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29210446

RESUMO

BACKGROUND AND OBJECTIVE: Noninvasive fat reduction appears effective, but there are various methods for quantifying changes. The objective of this review is to assess comparative utility measures of subcutaneous fat. STUDY DESIGN/MATERIALS AND METHODS: Articles describing noninvasive fat reduction were searched using MEDLINE, EMBASE, CINAHL and Scopus electronic databases on two dates (January 28, 2014 and February 16, 2016). Titles of studies and abstracts were screened for eligibility. Manual review was performed by two investigators to detect those that: (1) included original data; (2) were randomized controlled trials, or prospective or retrospective cohort studies; (3) quantified fat outcomes; and (4) enrolled at least 10 subjects. RESULTS: Of 1,057 retrieved articles, 36 met criteria. Most reported four or more measurement techniques. Circumference measurements were most commonly cited. Other objective techniques, like caliper thickness, ultrasound, magnetic resonance imaging (MRI), and three-dimensional (3D) photography, were also used. Common subjective methods were evaluation of standardized photographs by blinded raters and patient satisfaction surveys. CONCLUSIONS: For quantifying noninvasive fat reduction, all available methods had significant limitations: photographic comparisons were subjective; circumference or caliper measurements were confounded; ultrasound was operator dependent; MRI was expensive; computed models and simulations were in early development. As new technologies are developed, the need for reliable, accurate and practical measures of subcutaneous fat will increase. Lasers Surg. Med. 50:96-110, 2018. © 2017 Wiley Periodicals, Inc.


Assuntos
Técnicas Cosméticas , Lipectomia/métodos , Crioterapia/métodos , Ácido Desoxicólico/administração & dosagem , Diagnóstico por Imagem , Humanos , Terapia a Laser/métodos , Mesoterapia/métodos , Fotografação , Terapia por Radiofrequência , Terapia por Ultrassom/métodos
8.
Dermatol Surg ; 44(6): 855-864, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29799829

RESUMO

BACKGROUND: Compared with other imaging modalities, ultrasound is relatively deeply penetrating and can be used to evaluate deep dermal and subcutaneous structures. OBJECTIVE: Image skin thickness of the face and neck using high-frequency diagnostic ultrasound devices. MATERIALS AND METHODS: Skin overlying 20 different predesignated face and neck anatomic sites in 32 individuals was imaged using 2 commercially available high-frequency diagnostic ultrasound devices, a dedicated imaging device and a diagnostic device bundled with a therapeutic device. At each site, the subcutaneous and combined epidermal and dermal layer thicknesses were assessed by blinded expert raters. RESULTS: Similar skin thickness measurements were obtained. Notably, subcutaneous fat depth was measured to be 0.2 cm at the forehead; 0.5 cm at the mental eminence; and 0.6 cm at the submental, supraglenoid, and temporal regions. The combined epidermal and dermal thickness was approximately 0.1 cm at the zygomatic process, suborbital area, inferior malar region, gonion, supraglenoid area, and nasolabial-buccal, and nasolabial fold regions. CONCLUSION: This is the first study using high-resolution superficial diagnostic ultrasound to map skin thickness of the face and neck at standard anatomic locations. Ultrasound is an inexpensive, noninvasive, and convenient means to monitor dermatologic conditions and guide their treatment.


Assuntos
Derme/diagnóstico por imagem , Epiderme/diagnóstico por imagem , Face/diagnóstico por imagem , Pescoço/diagnóstico por imagem , Envelhecimento da Pele , Ultrassonografia/instrumentação , Centros Médicos Acadêmicos , Adolescente , Adulto , Idoso , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Ultrassonografia/métodos
9.
Dermatol Surg ; 43(10): 1249-1262, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28498204

RESUMO

BACKGROUND: Currently, the isotretinoin (13-cis-retinoic acid) package insert contains language advising the discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. It is common practice to follow this standard because of concerns regarding reports of sporadic adverse events and increased risk of scarring. OBJECTIVE: To develop expert consensus regarding the safety of skin procedures, including resurfacing, energy device treatments, and incisional and excisional procedures, in the setting of concurrent or recent isotretinoin use. MATERIALS AND METHODS: The American Society for Dermatologic Surgery authorized a task force of content experts to review the evidence and provide guidance. First, data were extracted from the literature. This was followed by a clinical question review, a consensus Delphi process, and validation of the results by peer review. RESULTS: The task force concluded that there is insufficient evidence to justify delaying treatment with superficial chemical peels and nonablative lasers, including hair removal lasers and lights, vascular lasers, and nonablative fractional devices for patients currently or recently exposed to isotretinoin. Superficial and focal dermabrasion may also be safe when performed by a well-trained clinician.


Assuntos
Abrasão Química , Dermabrasão , Fármacos Dermatológicos/uso terapêutico , Procedimentos Cirúrgicos Dermatológicos , Isotretinoína/uso terapêutico , Terapia a Laser , Segurança do Paciente/normas , Abrasão Química/efeitos adversos , Cicatriz/etiologia , Cicatriz/prevenção & controle , Dermabrasão/efeitos adversos , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Humanos , Terapia a Laser/efeitos adversos , Dermatopatias/etiologia , Dermatopatias/prevenção & controle
10.
Dermatol Online J ; 23(3)2017 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-28329517

RESUMO

A 60-year-old man with chronic lymphocytic leukemiadeveloped a deeply violaceous annular patchwith a halo of erythema on the right thigh duringhospitalization for neutropenic fever. Associatedsymptoms included chronic cough and fatigue.Bilateral lung opacities with hilar lymphadenopathywere noted on chest computed tomographyscan. Punch biopsy and tissue culture confirmeda diagnosis of secondary disseminated cutaneousmucormycosis. Although rare, physicians shouldinclude mucormycosis in the differential diagnosisof purpuric patches in immunosuppressed patients.Prompt skin biopsy and tissue culture may optimizethe success of treatment.


Assuntos
Dermatomicoses/diagnóstico , Hospedeiro Imunocomprometido , Leucemia Linfocítica Crônica de Células B/imunologia , Mucormicose/diagnóstico , Infarto Encefálico/diagnóstico por imagem , Infarto Encefálico/etiologia , Doenças Cerebelares/diagnóstico por imagem , Doenças Cerebelares/etiologia , Doenças Cerebelares/imunologia , Dermatomicoses/complicações , Dermatomicoses/imunologia , Dermatomicoses/patologia , Humanos , Embolia Intracraniana/diagnóstico por imagem , Embolia Intracraniana/etiologia , Leucemia Linfocítica Crônica de Células B/complicações , Linfadenopatia/diagnóstico por imagem , Linfadenopatia/etiologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mucormicose/complicações , Mucormicose/imunologia , Mucormicose/patologia , Coxa da Perna , Tórax , Tomografia Computadorizada por Raios X
11.
J Am Acad Dermatol ; 75(3): 585-589, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27125531

RESUMO

BACKGROUND: Guided imagery and music can reportedly reduce pain and anxiety during surgery, but no comparative study has been performed for cutaneous surgery to our knowledge. OBJECTIVES: We sought to determine whether short-contact recorded guided imagery or relaxing music could reduce patient pain and anxiety, and surgeon anxiety, during cutaneous surgical procedures. METHODS: Subjects were adults undergoing excisional surgery for basal and squamous cell carcinoma. Randomization was to guided imagery (n = 50), relaxing music (n = 54), or control group (n = 51). Primary outcomes were pain and anxiety measured using visual analog scale and 6-item short-form of the State-Trait Anxiety Inventory, respectively. Secondary outcomes were anxiety of surgeons measured by the 6-item short-form of the State-Trait Anxiety Inventory and physical stress of patients conveyed by vital signs, respectively. RESULTS: There were no significant differences in subjects' pain, anxiety, blood pressure, and pulse rate across groups. In the recorded guided imagery and the relaxing music group, surgeon anxiety was significantly lower than in the control group. LIMITATIONS: Patients could not be blinded. CONCLUSION: Short-contact recorded guided imagery and relaxing music appear not to reduce patient pain and anxiety during excisional procedures under local anesthetic. However, surgeon anxiety may be reduced when patients are listening to such recordings.


Assuntos
Ansiedade/prevenção & controle , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Imagens, Psicoterapia/métodos , Música/psicologia , Dor/prevenção & controle , Neoplasias Cutâneas/cirurgia , Adulto , Idoso , Ansiedade/etiologia , Carcinoma Basocelular/patologia , Carcinoma Basocelular/cirurgia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Procedimentos Cirúrgicos Dermatológicos/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor/etiologia , Medição da Dor , Satisfação do Paciente/estatística & dados numéricos , Terapia de Relaxamento , Medição de Risco , Método Simples-Cego , Neoplasias Cutâneas/patologia , Cirurgiões/psicologia , Resultado do Tratamento
12.
Dermatol Surg ; 42(3): 403-9, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26890802

RESUMO

BACKGROUND: Various forms of laser therapy including the pulsed-dye laser (PDL) have been reported to reduce acne lesion counts. OBJECTIVE: In this study, the benefits and complications when using a 595-nm PDL for the treatment of acne vulgaris were evaluated when comparing a subpurpuric (low) fluence level with a purpuric (high) fluence level. MATERIALS AND METHODS: This study was a prospective, single-blinded split-face clinical trial. Inclusion criteria included subjects with moderate to severe facial acne. All participants were treated with PDL, with each half of the face receiving either high or low fluence at 3-week intervals for a total of 4 treatments. Standardized facial photographs were obtained and blindly evaluated. RESULTS: Sixty-two subjects were enrolled with a mean age of 22.3 years. Fifty-five patients completed the study. The results showed a significant decrease in lesion counts compared with baseline after all treatments. However, the study did not demonstrate a statistically significant difference between the fluence parameters. The only treatment-related adverse event was temporary hyperpigmentation. CONCLUSION: This study demonstrates that PDL is effective in reducing acne lesions using purpuric and subpurpuric fluences. However, there was no statistically significant difference in acne lesion count between the higher and lower fluences.


Assuntos
Acne Vulgar/cirurgia , Lasers de Corante/uso terapêutico , Adolescente , Adulto , Feminino , Humanos , Hiperpigmentação/etiologia , Terapia a Laser/métodos , Lasers de Corante/efeitos adversos , Masculino , Memória Episódica , Fotogrametria , Púrpura/etiologia , Índice de Gravidade de Doença , Método Simples-Cego , Resultado do Tratamento , Adulto Jovem
13.
Skinmed ; 14(3): 230-1, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27502266

RESUMO

A six-year-old boy with Pallister-Killian syndrome (PKS) presented to the clinic with extensive lesions on his body (Figure 1). The patient was not born with the lesions but began developing them on the head and neck, extending to his lower extremities, at 2 years of age. These lesions had been evaluated by his primary care physician and were previously treated with desonide and ketoconazole cream with little improvement.


Assuntos
Transtornos Cromossômicos/complicações , Nevo/complicações , Criança , Transtornos Cromossômicos/patologia , Cromossomos Humanos Par 12 , Humanos , Masculino , Nevo/patologia
15.
Dermatol Online J ; 21(4)2015 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-25933075

RESUMO

Acrodermatitis enteropathica is a rare autosomal recessive disease characterized by pink scaly plaques and erosions in the periorificial and acral regions. A mutation in a gene responsible for zinc transport results in significant zinc deficiency in individuals lacking oral supplementation. We present a female infant with acrodermatitis enteropathica with crusting of the periorificial regions along with perineal plaques. A delay in diagnosis and treatment led to the development of pronounced painful acral bullae. Although plaques and erosions in the periorificial and acral regions are most commonly observed, bullae should also be considered in the spectrum of clinical manifestations of acrodermatitis enteropathica. The rare bullous variant of acrodermatitis enteropathica can be distinguished histologically.


Assuntos
Acrodermatite/patologia , Zinco/deficiência , Acrodermatite/tratamento farmacológico , Diagnóstico Tardio , Feminino , Humanos , Lactente , Períneo/patologia , Dedos do Pé/patologia , Vulva/patologia , Sulfato de Zinco/uso terapêutico
16.
Dermatol Online J ; 21(8)2015 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-26437157

RESUMO

Coccidioidomycosis (AKA "Valley fever") is a primary pulmonary infection via airborne spores released from coccidioides immitis in the soil. Reactive cutaneous eruptions resulting from the pulmonary infection are difficult to diagnose because skin biopsies do not contain the organism. We present an adolescent male with primary pulmonary C.immitis infection manifesting with biopsy proven subcorneal pustular dermatosis. Serological studies revealed increasingly positive titers for coccidioidomycosis and symptoms resolved promptly following initiation of systemic antifungal therapy. Our unique case presentation illustrates subcorneal pustular dermatosis as a reactive eruption owing to primary pulmonary coccidioidomycosis. An association between the two conditions warrants further investigation.


Assuntos
Coccidioides/isolamento & purificação , Coccidioidomicose/complicações , Erros de Diagnóstico , Pneumopatias Fúngicas/diagnóstico , Dermatopatias Vesiculobolhosas/etiologia , Adolescente , Antifúngicos/uso terapêutico , Dor nas Costas/etiologia , California , Coccidioidomicose/diagnóstico , Coccidioidomicose/tratamento farmacológico , Diagnóstico Tardio , Dermatite Alérgica de Contato/diagnóstico , Doenças Endêmicas , Reações Falso-Positivas , Fadiga/etiologia , Febre/etiologia , Fluconazol/uso terapêutico , Humanos , Pneumopatias Fúngicas/tratamento farmacológico , Pneumopatias Fúngicas/microbiologia , Masculino , Febre Maculosa das Montanhas Rochosas/diagnóstico , Dermatoses do Couro Cabeludo/etiologia , Dermatoses do Couro Cabeludo/microbiologia , Dermatopatias Vesiculobolhosas/tratamento farmacológico , Dermatopatias Vesiculobolhosas/microbiologia
17.
Dermatol Online J ; 20(11)2014 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-25419746

RESUMO

Necrolytic acral erythema (NAE) is a rare cutaneous sign of hepatitis C virus infection and has recently been linked to zinc deficiency. It presents as well-demarcated erythematous plaques in a sandal-like distribution on the dorsal feet with psoriasiform epidermal hyperplasia on histology. Our patient reported a 9-month history of progressive bilateral lower extremity erythema, swelling, erosions, and nail dystrophy that failed to improve despite multiple courses of antibiotics for presumed lower extremity cellulitis. Serum studies revealed zinc deficiency. This case supports the association of NAE with both HCV infection and zinc deficiency and highlights the pitfalls in the diagnosis of chronic unrecognized NAE. Suspected cases of NAE should prompt evaluation for underlying HCV and zinc deficiency to avoid treatment delay and associated complications.


Assuntos
Celulite (Flegmão)/diagnóstico , Eritema/etiologia , Hepatite C/complicações , Pele/patologia , Zinco/deficiência , Erros de Diagnóstico , Eritema/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Unha/etiologia , Necrose/etiologia , Necrose/patologia , Zinco/sangue
18.
Cutis ; 106(6): 307-308, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33471874

RESUMO

Tuberous sclerosis complex (TSC) is an autosomal-dominant disorder that causes the formation of hamartomatous tumors such as facial angiofibromas (FAs). We present a combination of surgical debulking via shave biopsy, curettage, and electrocautery followed by application of sirolimus ointment 1% to the nose to treat FAs in the setting of TSC. This novel approach achieved an optimal therapeutic response in our patient with minimal recurrence of FAs after 1 year of follow-up.


Assuntos
Angiofibroma , Neoplasias Faciais , Esclerose Tuberosa , Angiofibroma/tratamento farmacológico , Procedimentos Cirúrgicos de Citorredução , Neoplasias Faciais/tratamento farmacológico , Humanos , Recidiva Local de Neoplasia , Sirolimo/uso terapêutico , Esclerose Tuberosa/complicações
19.
Pathol Oncol Res ; 26(1): 239-244, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29948620

RESUMO

Cutaneous adnexal malignancies are biologically and pathologically diverse, and associated with a range of clinical outcomes. Given their rarity, the prognosis and optimal treatment of these neoplasms remains unclear. A single institution database from a tertiary care cancer center of patients treated for malignant cutaneous adnexal tumors was retrospectively analyzed. Clinicopathologic variables and outcome measures were analyzed in patients undergoing wide excision with or without sentinel node biopsy. 103 patients were analyzed; the majority of tumors were of eccrine sweat gland derivation (n = 69, 70%), and these exhibited a higher rate of nodal involvement and overall worse outcome. Sixteen patients (16%) demonstrated nodal metastasis, which included 10 (10%) with nodal disease at presentation and 6 who developed nodal metastasis during followup. 20 patients underwent sentinel node biopsy, and 2 (10%) had a positive sentinel node. 62% of nodal metastases occurred in patients with porocarcinoma. Seven patients died of disease (7%) with a median time from diagnosis to death of 48 months (range, 10-174). After a median follow up of 44.7 months, age > 70 years and larger tumor size were significantly associated with worse overall survival. Adnexal malignancies are rare tumors, and there is a paucity of information to guide the clinician in determining optimum surgical and medical treatment. Tumors of eccrine derivation, especially porocarcinomas, have a high risk of nodal involvement and may be considered for sentinel node biopsy.


Assuntos
Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Neoplasias Cutâneas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias de Anexos e de Apêndices Cutâneos/mortalidade , Neoplasias de Anexos e de Apêndices Cutâneos/terapia , Estudos Retrospectivos , Neoplasias Cutâneas/mortalidade , Neoplasias Cutâneas/terapia , Adulto Jovem
20.
JAMA Dermatol ; 156(3): 326-333, 2020 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-31939999

RESUMO

Importance: Although various treatments have been found in clinical trials to be effective in treating actinic keratosis (AK), researchers often report different outcomes. Heterogeneous outcome reporting precludes the comparison of results across studies and impedes the synthesis of treatment effectiveness in systematic reviews. Objective: To establish an international core outcome set for all clinical studies on AK treatment using systematic literature review and a Delphi consensus process. Evidence Review: Survey study with a formal consensus process. The keywords actinic keratosis and treatment were searched in PubMed, Embase, CINAHL, and the Cochrane Library to identify English-language studies investigating AK treatments published between January 1, 1980, and July 13, 2015. Physician and patient stakeholders were nominated to participate in Delphi surveys by the Measurement of Priority Outcome Variables in Dermatologic Surgery Steering Committee members. All participants from the first round were invited to participate in the second round. Outcomes reported in randomized controlled clinical trials on AK treatment were rated via web-based e-Delphi consensus surveys. Stakeholders were asked to assess the relative importance of each outcome in 2 Delphi survey rounds. Outcomes were provisionally included, pending the final consensus conference, if at least 70% of patient or physician stakeholders rated the outcome as critically important in 1 or both Delphi rounds and the outcome received a mean score of 7.5 from either stakeholder group. Data analysis was performed from November 5, 2018, to February 27, 2019. Findings: A total of 516 outcomes were identified by reviewing the literature and surveying key stakeholder groups. After deduplication and combination of similar outcomes, 137 of the 516 outcomes were included in the Delphi surveys. Twenty-one physicians and 12 patients participated in round 1 of the eDelphi survey, with 17 physicians (81%) retained and 12 patients (100%) retained in round 2. Of the 137 candidate outcomes, 9 met a priori Delphi consensus criteria, and 6 were included in the final outcomes set after a consensus meeting: complete clearance of AKs, percentage of AKs cleared, severity of adverse events, patient perspective on effectiveness, patient-reported future treatment preference, and recurrence rate. It was recommended that treatment response be assessed at 2 to 4 months and recurrence at 6 to 12 months, with the AK rate of progression to cutaneous squamous cell carcinoma reported whenever long-term follow-up was possible. Conclusions and Relevance: Consensus was reached regarding a core outcome set for AK trials. Further research may help determine the specific outcome measures used to assess each of these outcomes.


Assuntos
Ceratose Actínica/terapia , Avaliação de Resultados em Cuidados de Saúde , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Idoso , Carcinoma de Células Escamosas/etiologia , Consenso , Técnica Delphi , Progressão da Doença , Feminino , Humanos , Ceratose Actínica/complicações , Ceratose Actínica/patologia , Masculino , Pessoa de Meia-Idade , Recidiva , Neoplasias Cutâneas/etiologia , Inquéritos e Questionários , Fatores de Tempo
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