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1.
Vaccines (Basel) ; 9(2)2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33557233

RESUMO

Molecular epidemiological data on Group A Streptococcus (GAS) infection in Africa is scarce. We characterized the emm-types and emm-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 and 2018. To reduce the potential for strain mistyping, we used a newly published primer for emm-typing. There was considerable strain diversity, highlighting the need for vaccine development offering broad strain protection.

2.
PLoS One ; 16(8): e0241942, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34464385

RESUMO

The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the understanding and link between local transmission and other global populations. The objective of this analysis was to provide genomic data on the first six cases of SARS-CoV-2 in The Gambia and to determine the source of infection. This ultimately provide baseline data for subsequent local transmission and contribute genomic diversity information towards local and global data. Our analysis has shown that the SARS-CoV-2 virus identified in The Gambia are of European and Asian origin and sequenced data matched patients' travel history. In addition, we were able to show that two COVID-19 positive cases travelling in the same flight had different strains of SARS-CoV-2. Although whole genome sequencing (WGS) data is still limited in sub-Saharan Africa, this approach has proven to be a highly sensitive, specific and confirmatory tool for SARS-CoV-2 detection.


Assuntos
COVID-19/patologia , Genoma Viral , SARS-CoV-2/genética , COVID-19/virologia , Gâmbia , Variação Genética , Humanos , Funções Verossimilhança , Filogenia , SARS-CoV-2/classificação , SARS-CoV-2/isolamento & purificação , Sequenciamento Completo do Genoma
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