Detalhe da pesquisa
1.
The Positive Allosteric Modulator of α2/3-Containing GABAA Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury.
J Pharmacol Exp Ther
; 372(1): 83-94, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31694876
2.
GABAA Receptor Subtypes and the Abuse-Related Effects of Ethanol in Rhesus Monkeys: Experiments with Selective Positive Allosteric Modulators.
Alcohol Clin Exp Res
; 43(5): 791-802, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30861153
3.
A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung.
Mol Pharm
; 15(5): 1766-1777, 2018 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29578347
4.
Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators.
Mol Pharm
; 14(6): 2088-2098, 2017 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28440659
5.
Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction.
Am J Respir Cell Mol Biol
; 54(4): 546-53, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26405827
6.
Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.
Mol Pharm
; 13(6): 2026-38, 2016 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27120014
7.
Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung".
Mol Pharm
; 16(11): 4756, 2019 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31633359
8.
Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding.
Structure
; 31(1): 20-32.e5, 2023 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36513069
9.
Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.
ACS Omega
; 7(19): 16584-16592, 2022 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35601290
10.
Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
ACS Pharmacol Transl Sci
; 5(5): 331-343, 2022 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35592436
11.
Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core.
Pharmaceuticals (Basel)
; 14(10)2021 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34681248
12.
Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects.
ACS Chem Neurosci
; 11(17): 2624-2637, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786313
13.
The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs: The example of CERC-611 and KRM-II-81.
Brain Res
; 1722: 146356, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31369732
14.
Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain.
Synthesis (Stuttg)
; 50(20): 4124-4132, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32773890
15.
Optimization of substituted imidazobenzodiazepines as novel asthma treatments.
Eur J Med Chem
; 126: 550-560, 2017 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27915170