Detalhe da pesquisa
1.
Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.
Proc Natl Acad Sci U S A
; 120(22): e2220979120, 2023 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216510
2.
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35110404
3.
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.
Proc Natl Acad Sci U S A
; 117(26): 15281-15292, 2020 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32546520
4.
Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.
Gut
; 71(4): 695-704, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785555
5.
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
J Neurosci
; 41(1): 193-210, 2021 01 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33172978
6.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A
; 115(31): E7438-E7447, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012612
7.
Protein kinase D and Gßγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
J Biol Chem
; 294(27): 10649-10662, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142616
8.
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
Gastroenterology
; 157(2): 507-521.e4, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31071306
9.
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Proc Natl Acad Sci U S A
; 114(46): 12309-12314, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087309
10.
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.
Am J Physiol Heart Circ Physiol
; 314(3): H580-H592, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29350998
11.
Protein Kinase D and Gßγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.
J Biol Chem
; 291(21): 11285-99, 2016 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27030010
12.
Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum.
Hepatology
; 63(4): 1287-98, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26426865
13.
Endothelin-converting enzyme 1 and ß-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.
J Biol Chem
; 289(29): 20283-94, 2014 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24898255
14.
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
J Biol Chem
; 289(39): 27215-27234, 2014 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25118282
15.
The bile acid receptor TGR5 does not interact with ß-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
J Biol Chem
; 288(32): 22942-60, 2013 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818521
16.
Repurposing EGFR Inhibitors for Oral Cancer Pain and Opioid Tolerance.
Pharmaceuticals (Basel)
; 16(11)2023 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38004424
17.
Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory Nanocarriers.
Pharmaceutics
; 16(1)2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38276488
18.
Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2.
Cell Mol Gastroenterol Hepatol
; 14(4): 841-876, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35840034
19.
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice.
Nat Commun
; 13(1): 646, 2022 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35115501
20.
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain.
Biomaterials
; 285: 121536, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35533442