Detalhe da pesquisa
1.
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Bioorg Med Chem Lett
; 29(11): 1380-1385, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30952592
2.
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Bioorg Med Chem Lett
; 29(10): 1182-1186, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926247
3.
SAR exploration at the C-3 position of tetrahydro-ß-carboline sstr3 antagonists.
Bioorg Med Chem Lett
; 26(6): 1529-1535, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898814
4.
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(21): 4945-4949, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978966
5.
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(22): 5437-43, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318999
6.
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Bioorg Med Chem Lett
; 20(15): 4483-6, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598533
7.
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorg Med Chem Lett
; 20(16): 4895-900, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20621473
8.
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorg Med Chem Lett
; 20(22): 6524-32, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933410
9.
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Bioorg Med Chem Lett
; 20(6): 1913-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20167483
10.
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorg Med Chem Lett
; 20(7): 2106-10, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207541
11.
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(7): 2074-7, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20219372
12.
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(15): 4399-405, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20598882
13.
Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.
ACS Med Chem Lett
; 6(5): 513-7, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005524
14.
Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin.
J Med Chem
; 47(12): 2965-8, 2004 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15163176
15.
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 5(10): 1082-7, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349648
16.
Investigation of Cardiovascular Effects of Tetrahydro-ß-carboline sstr3 antagonists.
ACS Med Chem Lett
; 5(7): 748-53, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050159
17.
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 4(8): 773-8, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900745
18.
The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.
ACS Med Chem Lett
; 3(6): 484-9, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900499
19.
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Cell Metab
; 11(2): 101-12, 2010 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20096642
20.
Synthesis of novel 4'-substituted 16-membered ring macrolide antibiotics derived from leucomycins.
Bioorg Med Chem Lett
; 14(2): 519-21, 2004 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-14698194