Detalhe da pesquisa
1.
Bifunctional TGF-ß trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors.
Mol Ther
; 29(10): 2949-2962, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34091051
2.
Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques.
J Infect Dis
; 218(suppl_5): S658-S661, 2018 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30053153
3.
Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate.
J Infect Dis
; 218(suppl_5): S636-S648, 2018 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30010950
4.
Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy.
Clin Infect Dis
; 66(7): 1116-1119, 2018 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29272362
5.
Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus.
J Virol
; 91(14)2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28468884
6.
Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.
Aging Cell
; 22(5): e13806, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36967480
7.
A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy.
Cancer Immunol Res
; 9(9): 1071-1087, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244297
8.
Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study.
Lancet Infect Dis
; 18(4): 410-418, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29329957
9.
Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice.
Antiviral Res
; 146: 164-173, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28893603
10.
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.
Sci Transl Med
; 8(326): 326ra21, 2016 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26888429
11.
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Sci Rep
; 6: 24897, 2016 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109916
12.
Species-Specific Chromosome Engineering Greatly Improves Fully Human Polyclonal Antibody Production Profile in Cattle.
PLoS One
; 10(6): e0130699, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26107496
13.
Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses.
PLoS One
; 10(9): e0137786, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26422247
14.
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production.
PLoS One
; 9(3): e90383, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24603704
15.
DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome.
Sci Transl Med
; 6(264): 264ra162, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25429055
16.
Physiological level production of antigen-specific human immunoglobulin in cloned transchromosomic cattle.
PLoS One
; 8(10): e78119, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24205120
17.
Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site.
Thromb Haemost
; 103(1): 224-33, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20062929
18.
Antigen-specific human polyclonal antibodies from hyperimmunized cattle.
Nat Biotechnol
; 27(2): 173-81, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19151699
19.
Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure.
Am J Physiol Lung Cell Mol Physiol
; 290(1): L21-31, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16100288
20.
In vitro and in vivo characterization of a novel antibody-like single-chain TCR human IgG1 fusion protein.
J Immunol
; 174(7): 4381-8, 2005 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15778403