Ocimum sanctum L (Holy Basil or Tulsi) and its phytochemicals in the prevention and treatment of cancer.

Ocimum sanctum L. or Ocimum tenuiflorum L, commonly known as the Holy Basil in English or Tulsi in the various Indian languages, is a important medicinal plant in the various traditional and folk systems of medicine in Southeast Asia. Scientific studies have shown it to possess antiinflammatory, analgesic, antipyretic, antidiabetic, hepatoprotective, hypolipidemic, antistress, and immunomodulatory activities. Preclinical studies have also shown that Tulsi and some of its phytochemicals eugenol, rosmarinic acid, apigenin, myretenal, luteolin, ß-sitosterol, and carnosic acid prevented chemical-induced skin, liver, oral, and lung cancers and to mediate these effects by increasing the antioxidant activity, altering the gene expressions, inducing apoptosis, and inhibiting angiogenesis and metastasis. The aqueous extract of Tulsi and its flavanoids, orintin, and vicenin are shown to protect mice against γ-radiation-induced sickness and mortality and to selectively protect the normal tissues against the tumoricidal effects of radiation. The other important phytochemicals like eugenol, rosmarinic acid, apigenin, and carnosic acid are also shown to prevent radiation-induced DNA damage. This review summarizes the results related to the chemopreventive and radioprotective properties of Tulsi and also emphasizes aspects that warrant future research to establish its activity and utility in cancer prevention and treatment.

Are medical students inclined to do research?".

BACKGROUND: Medical research at undergraduate level has been given poor importance in developing countries including India. Less incentives, poor resources, lack of benefits has all been the reason for curbing the research interests of the students. OBJECTIVE: This research was done to understand if medical students perceived research to be important at an undergraduate level, to understand the reasons for doing research and the benefits obtained from research. STUDY DESIGN: Cross sectional study. MATERIAL AND METHODS: Questionnaires were distributed to medical students studying in second, third, fourth and fifth years in the MBBS course at an undergraduate medical conference and a medical college. Questions were so designed to verify student's ideas on research, their research involvement and their reasons for conducting research. The answers were tabulated, data analyzed and statistics were made based on their answers. STATISTICAL ANALYSIS: Frequency and percentage. RESULTS: Out of the given sample, it was seen that though only 20.9% of the students had credited publications, 81.7% of the students admitted to research being essential to understanding and changing their perception of medicine. Only 38.3% of the sample found research to be cumbersome. 24.3% of the students were involved in research purely for the purpose of acquiring knowledge, 18.3% were pursuing interest in the field and a meager 1.7% were doing research to improve their curriculum vitae. Conclusion : These results are in conformance with other studies from elsewhere that shows decreased Indian medical student's engagement in researches, compared to those from developed countries, but on par with those from the developing countries.