A new multivariate index for ecological security assessment in the China-Myanmar border region.

The coordination of development efforts and ecological conservation in China's border regions is a significant challenge due to the overlap of biodiversity hotspots, ecologically fragile zones, and impoverished areas. Achieving the harmonious integration of ecological preservation and economic development relies on the fundamental assessment of ecological security (ES). However, comprehensive assessments of ES in border regions remain limited. This study introduces a new index, the multivariate ecological security index (MESI), which integrates ecosystem vigor, organization, elasticity, services and risk. Here, the MESI was utilized to assess the temporal and spatial changes in ES and its associated impact factors in the China-Myanmar border region (CMBR) from 2000 to 2020. The MESI provides a clear representation of the actual ES status in the CMBR, exhibiting a significant correlation with the eco-environmental quality index (EEQI; p < 0.01). The ES status exhibited notable spatial heterogeneity in the CMBR, consisting primarily of both relatively safe and safe levels, which accounted for approximately 85% of the total area. From 2000 to 2020, the CMBR experienced a gradual improvement in ES status, with the area experiencing an increase in the ES level accounting for 23.41% of the total area, which exceeded the proportion of the area experiencing a decrease in the ES level (4.71%). The combined impact of multiple factors exerted a greater influence on ES than did individual factors alone. Notably, human factors increasingly influenced the ES status during the study period. The results of this study provide valuable insights for ecological preservation and sustainable management in the CMBR, and the MESI can be extended to assess the ES of other regions.

Oxygen migration performance of LaFeO3 perovskite-type oxygen carriers with Sr doping.

A perovskite-type metal oxide with the formula of ABO3 exhibits excellent redox reaction properties for the chemical looping process, where A is usually an alkaline earth metal and B is a transition metal. The oxygen transfer property plays an important role in the performance of oxygen carriers. In this study, the difference in oxygen vacancy formation energy and oxygen migration barrier between the surface and the bulk in the LaFeO3 (ABO3 type) perovskite is investigated via density functional theory (DFT). The effect of Sr doping on the A-site is considered. The results show that the covalency of the interaction between Fe and O at the surface is higher than that in the bulk, and the Sr doping on the A-site enhances this covalency, leading to a lower oxygen vacancy formation energy. The oxygen migration barrier is also different with the distance from the surface. A smaller deviation of the surrounding lattice atoms from their original place in the crystal at a deeper layer leads to a higher oxygen migration energy. Meanwhile, Sr doping increases the lattice constant, leading to larger migration space thus lowering the migration barrier. In addition, Sr doping can weaken the difference in the oxygen migration barrier between near the surface and in the bulk.

Unraveling interactions and priorities under sustainable development goals in less-developed mountainous areas: case study on the National Innovation Demonstration Zone for the 2030 Agenda for Sustainable Development, China.

Understanding the intricate relationships between progress and the United Nations' 17 Sustainable Development Goals (SDGs) is vital for informed and adaptable sustainable development policy formulation. This study focused on the Lincang National Innovation Demonstration Zone for the 2030 Agenda for Sustainable Development (LC-NIDZASD) in China. By evaluating sustainability scores at the county level from 2011 to 2020, the trade-offs and synergies among SDGs were explored. Priority SDGs for development were identified, and targeted recommendations were established based on these findings. The key findings are as follows: (1) The SDG index scores of Lincang and its counties showed an increase from 2011 to 2020, with scores riding from 42.1 to 52.2. SDG6 (Clean Water and Sanitation) and SDG12 (Responsible Production and Consumption) had the highest scores, while SDG1 (No Poverty) and SDG4 (Quality Education) increased significantly. However, the COVID-19 pandemic led to a decrease in the scores of SDG1, SDG8 (Decent Jobs and Economic Growth), and SDG17 (Partnerships for the Goals) in 2020 decreased compared to 2019. Decreased scores in SDG13 (Climate Action) and SDG15 (Life on Land) may be attributable to climate change. (2) The relationship between "Objectives" and ''Governance" appears to be synergistic, while ''Essential Needs" mainly shows a trade-off relationship with ''Objectives" and ''Governance." (3) To promote achievements in the construction of LC-NIDZASD, priority should be given to SDG3 (Health and Well-Being), SDG8, SDG9 (Industry, Innovation, and Infrastructure), and SDG12; SDG4 should not be ignored. (4) Overall, Lincang has made significant progress in sustainable development. However, to further consolidate these achievements, adjustments should be made for SDG7 (Energy Consumption and Production Structure). Efforts should be made to strengthen climate governance measures and improve warning and forecasting capabilities to promote the synergistic development of SDG7 (Affordable and Clean Energy) and SDG13 with other SDGs. This study's dynamic monitoring of changes in the SDGs in Lincang provides valuable insights into the synergies and trade-offs among these goals. Appropriate prioritization across various SDGs can allow for timely adjustments in sustainable management policies, ultimately contributing to the successful operation of the LC-NIDZASD.

Seeking the adsorption of tetracycline in water by Fe-modified sludge biochar at different pyrolysis temperatures.

The composite material SBC-Fe-x with sludge and Fe3+ was developed by different calcination temperatures (600, 700, and 800 °C) for the removal of tetracycline (TC). The adsorption rates of SBC-Fe-600, SBC-Fe-700, and SBC-Fe-800 were 77.5%, 89%, and 91%, respectively. Furthermore, the Langmuir model indicated that the maximum adsorption capacity of SBC-Fe-700 (157.93 mg/g) was three times greater than that of SBC-Fe-600. The conclusions were confirmed by a series of characterizations that SBC-Fe-700 showed a larger specific surface area, well-developed pore structure, rich oxygen-containing functional groups and a high degree of graphitization. The results of pH experiments indicated the broad applicability of SBC-Fe-700 for TC adsorption. In addition, SBC-Fe-700 suggested outstanding performance in different water environments. This work produced a feasible adsorbent for the removal of TC, and a new direction for sludge resource utilization was proposed.

G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.

PURPOSE: To investigate the role and underlying mechanism of G9a and CCDC8 in lung cancer radioresistance. METHODS: Western blotting assays were used for G9a, CCDC8, H3K9me3 expression detection. MTT assays and clone formation assays were used for measuring cell proliferation activities. Flow cytometry assays were used for cell apoptosis detection. The enrichment of H3K9me3 in CCDC8 promoter was measured by chromatin immunoprecipitation assay. RESULTS: G9a and G9a-mediated H3K9me3 are upregulated in radioresistant lung cancer cells (A549/IR cell and XWLC-05/IR cell). Blocking G9a not only promotes radiosensitivity of A549/IR cell and XWLC-05/IR cell but also reduces aggressive behavior of radioresistant A549 cell/IR and XWLC-05/IR cell. In addition, G9a-controlled H3K9me3 is able to binding to the promoter of tumor suppressor gene CCDC8 and suppresses CCDC8 expression. CCDC8 dysregulation is responsible for G9a-mediated radioresistance of A549/IR cell and XWLC-05/IR cell. CONCLUSION: G9a and H3K9me3 contribute to the lung cancer radioresistance via modulating CCDC8 expression.

Complete mitochondrial genome sequence and mutations of the lung carcinoma model inbred C57BL/6 mice strain.

In the present work, we undertook the complete mitochondrial genome sequencing of an important lung carcinoma model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, and one non-coding control region (D-loop region). The mutation events were also reported.

Benzopyrene promotes lung cancer A549 cell migration and invasion through up-regulating cytokine IL8 and chemokines CCL2 and CCL3 expression.

Tobacco-sourced carcinogen including benzopyrene (B[a]P) in lung cancer metastasis has not been fully reported. In this study, lung carcinoma A549 cell line was used to investigate the potential roles of tobacco-sourced B[a]P on cell metastasis and invasion and to assess its underlying mechanism. Effects of tobacco-sourced carcinogen on A549 cell proliferation, metastasis, and invasion were analyzed using MTT assay, Transwell assay, and scratch method, respectively. The effects of tobacco-sourced carcinogen on cytokines and chemokines secretion were detected using enzyme-linked immunosorbent assay. Moreover, correlation between inflammatory factor expression and cancer cell migration and invasion was assessed using siRNA-mediated gene silencing. Data showed that both B[a]P and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone either at high or low dose performed no significant difference on A549 cell proliferation with time increasing. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone performed no significant difference on A549 cell migration and invasion while B[a]P significantly increased A549 cell migration and invasion compared to the control group (P < 0.05). Consequently, except for IL-6, IL-8, CCL-2, and CCL-3, secretions were significantly increased by B[a]P treatment compared to the control (P < 0.05). Furthermore, when CCL-2 and CCL-3 were silenced, the migrated and invasive A549 cells were significantly decreased compared to the control, respectively (P < 0.05), while silenced IL-8 drastically decreased the migrated and invasive cells compared to the control (P < 0.01). Taken together, this study illustrated that there may be significant correlation between smoking and lung cancer metastasis. B[a]P maybe an excellent contributor for lung cancer metastasis through up-regulating IL-8, CCL-2, and CCL-3 expression.