Assuntos
Antagonistas dos Receptores Histamínicos H1/farmacologia , Piperazinas/farmacologia , Tranquilizantes/farmacologia , Animais , Peso Corporal/efeitos dos fármacos , Etilestrenol/farmacologia , Fezes/análise , Fezes/efeitos dos fármacos , Feminino , Nitrogênio/análise , Nitrogênio/urina , Ratos , Ratos EndogâmicosAssuntos
Antagonistas dos Receptores Histamínicos H1/farmacologia , Parassimpatolíticos , Animais , Arecolina/antagonistas & inibidores , Feminino , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Humanos , Hipercinese/prevenção & controle , Masculino , Camundongos , Nicotina/antagonistas & inibidores , Pilocarpina/antagonistas & inibidores , Salivação/efeitos dos fármacos , Espasmo/prevenção & controle , Tremor/prevenção & controleAssuntos
Comportamento Animal/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos H1/farmacologia , Músculo Liso/efeitos dos fármacos , Reflexo/efeitos dos fármacos , Sono/efeitos dos fármacos , Animais , Sinergismo Farmacológico , Cobaias , Íleo/efeitos dos fármacos , Técnicas In Vitro , Masculino , Camundongos , Pentobarbital/farmacologiaRESUMO
The anti-fertility activity of prostaglandin synthesis inhibitors namely the non-steroidal anti-inflammatory drugs: acetyl salicylic acid, indomethacin and oxyphenbutazone were investigated in male and female albino rats and female albino rabbits. Oxyphenbutazone and indomethacin affected the reproductive process in male rats. Indomethacin 3 mg/kg. and acetyl salicylic acid 300 mg/kg produced significant anti-ovulatory activity in the rabbit. In female rats, all three drugs given in high doses over a period of two oestrous cycles reduced mating significantly, while only indomethacin given in a low dose of 0.8 mg/kg over a period of six oestrous cycles could reduce mating significantly. Anti-implantation activity was seen with indomethacin 4 mg/kg. alone, and though post-implantation activity was seen with all three drugs, it was associated with maternal deaths. It appears that non-steroidal anti-inflammatory drugs affect reproduction in female animals.