Pesquisa | BVS Violência e Saúde

1.

Emerging Cellular Therapies for Cancer.

Guedan, Sonia; Ruella, Marco; June, Carl H.

Annu Rev Immunol ; 37: 145-171, 2019 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-30526160

2.

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells.

Tsuchida, Connor A; Brandes, Nadav; Bueno, Raymund; Trinidad, Marena; Mazumder, Thomas; Yu, Bingfei; Hwang, Byungjin; Chang, Christopher; Liu, Jamin; Sun, Yang; Hopkins, Caitlin R; Parker, Kevin R; Qi, Yanyan; Hofman, Laura; Satpathy, Ansuman T; Stadtmauer, Edward A; Cate, Jamie H D; Eyquem, Justin; Fraietta, Joseph A; June, Carl H; Chang, Howard Y; Ye, Chun Jimmie; Doudna, Jennifer A.

Cell ; 186(21): 4567-4582.e20, 2023 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-37794590

3.

CAR T therapy extends its reach to autoimmune diseases.

Baker, Daniel J; June, Carl H.

Cell ; 185(24): 4471-4473, 2022 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-36423579

4.

Adoptive immunotherapy for cancer or viruses.

Maus, Marcela V; Fraietta, Joseph A; Levine, Bruce L; Kalos, Michael; Zhao, Yangbing; June, Carl H.

Annu Rev Immunol ; 32: 189-225, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24423116

5.

The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function.

Johnson, Lexus R; Lee, Daniel Y; Eacret, Jacqueline S; Ye, Darwin; June, Carl H; Minn, Andy J.

Cell ; 184(19): 4981-4995.e14, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34464586

6.

An NK-like CAR T cell transition in CAR T cell dysfunction.

Good, Charly R; Aznar, M Angela; Kuramitsu, Shunichiro; Samareh, Parisa; Agarwal, Sangya; Donahue, Greg; Ishiyama, Kenichi; Wellhausen, Nils; Rennels, Austin K; Ma, Yujie; Tian, Lifeng; Guedan, Sonia; Alexander, Katherine A; Zhang, Zhen; Rommel, Philipp C; Singh, Nathan; Glastad, Karl M; Richardson, Max W; Watanabe, Keisuke; Tanyi, Janos L; O'Hara, Mark H; Ruella, Marco; Lacey, Simon F; Moon, Edmund K; Schuster, Stephen J; Albelda, Steven M; Lanier, Lewis L; Young, Regina M; Berger, Shelley L; June, Carl H.

Cell ; 184(25): 6081-6100.e26, 2021 12 09.

Artigo em Inglês | MEDLINE | ID: mdl-34861191

7.

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.

Parker, Kevin R; Migliorini, Denis; Perkey, Eric; Yost, Kathryn E; Bhaduri, Aparna; Bagga, Puneet; Haris, Mohammad; Wilson, Neil E; Liu, Fang; Gabunia, Khatuna; Scholler, John; Montine, Thomas J; Bhoj, Vijay G; Reddy, Ravinder; Mohan, Suyash; Maillard, Ivan; Kriegstein, Arnold R; June, Carl H; Chang, Howard Y; Posey, Avery D; Satpathy, Ansuman T.

Cell ; 183(1): 126-142.e17, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32961131

8.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Benci, Joseph L; Johnson, Lexus R; Choa, Ruth; Xu, Yuanming; Qiu, Jingya; Zhou, Zilu; Xu, Bihui; Ye, Darwin; Nathanson, Katherine L; June, Carl H; Wherry, E John; Zhang, Nancy R; Ishwaran, Hemant; Hellmann, Matthew D; Wolchok, Jedd D; Kambayashi, Taku; Minn, Andy J.

Cell ; 178(4): 933-948.e14, 2019 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-31398344

9.

Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.

Agarwal, Sangya; Aznar, M Angela; Rech, Andrew J; Good, Charly R; Kuramitsu, Shunichiro; Da, Tong; Gohil, Mercy; Chen, Linhui; Hong, Seok-Jae Albert; Ravikumar, Pranali; Rennels, Austin K; Salas-Mckee, January; Kong, Weimin; Ruella, Marco; Davis, Megan M; Plesa, Gabriela; Fraietta, Joseph A; Porter, David L; Young, Regina M; June, Carl H.

Immunity ; 56(10): 2388-2407.e9, 2023 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-37776850

10.

The Principles of Engineering Immune Cells to Treat Cancer.

Lim, Wendell A; June, Carl H.

Cell ; 168(4): 724-740, 2017 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-28187291

11.

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers.

Giles, Josephine R; Manne, Sasikanth; Freilich, Elizabeth; Oldridge, Derek A; Baxter, Amy E; George, Sangeeth; Chen, Zeyu; Huang, Hua; Chilukuri, Lakshmi; Carberry, Mary; Giles, Lydia; Weng, Nan-Ping P; Young, Regina M; June, Carl H; Schuchter, Lynn M; Amaravadi, Ravi K; Xu, Xiaowei; Karakousis, Giorgos C; Mitchell, Tara C; Huang, Alexander C; Shi, Junwei; Wherry, E John.

Immunity ; 55(3): 557-574.e7, 2022 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-35263570

12.

CAR T therapy beyond cancer: the evolution of a living drug.

Baker, Daniel J; Arany, Zoltan; Baur, Joseph A; Epstein, Jonathan A; June, Carl H.

Nature ; 619(7971): 707-715, 2023 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-37495877

13.

Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Kalbasi, Anusha; Siurala, Mikko; Su, Leon L; Tariveranmoshabad, Mito; Picton, Lora K; Ravikumar, Pranali; Li, Peng; Lin, Jian-Xin; Escuin-Ordinas, Helena; Da, Tong; Kremer, Sarah V; Sun, Amy L; Castelli, Sofia; Agarwal, Sangya; Scholler, John; Song, Decheng; Rommel, Philipp C; Radaelli, Enrico; Young, Regina M; Leonard, Warren J; Ribas, Antoni; June, Carl H; Garcia, K Christopher.

Nature ; 607(7918): 360-365, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35676488

14.

Decade-long leukaemia remissions with persistence of CD4⁺ CAR T cells.

Melenhorst, J Joseph; Chen, Gregory M; Wang, Meng; Porter, David L; Chen, Changya; Collins, McKensie A; Gao, Peng; Bandyopadhyay, Shovik; Sun, Hongxing; Zhao, Ziran; Lundh, Stefan; Pruteanu-Malinici, Iulian; Nobles, Christopher L; Maji, Sayantan; Frey, Noelle V; Gill, Saar I; Loren, Alison W; Tian, Lifeng; Kulikovskaya, Irina; Gupta, Minnal; Ambrose, David E; Davis, Megan M; Fraietta, Joseph A; Brogdon, Jennifer L; Young, Regina M; Chew, Anne; Levine, Bruce L; Siegel, Donald L; Alanio, Cécile; Wherry, E John; Bushman, Frederic D; Lacey, Simon F; Tan, Kai; June, Carl H.

Nature ; 602(7897): 503-509, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35110735

15.

Beyond youth: Understanding CAR T cell fitness in the context of immunological aging.

Noll, Julia Han; Levine, Bruce L; June, Carl H; Fraietta, Joseph A.

Semin Immunol ; 70: 101840, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37729825

16.

IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation.

Tilsed, Caitlin M; Sadiq, Barzan A; Papp, Tyler E; Areesawangkit, Phurin; Kimura, Kenji; Noguera-Ortega, Estela; Scholler, John; Cerda, Nicholas; Aghajanian, Haig; Bot, Adrian; Mui, Barbara; Tam, Ying; Weissman, Drew; June, Carl H; Albelda, Steven M; Parhiz, Hamideh.

Proc Natl Acad Sci U S A ; 121(13): e2319856121, 2024 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-38513098

17.

Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α.

Roselle, Christopher; Horikawa, Izumi; Chen, Linhui; Kelly, Andre R; Gonzales, Donna; Da, Tong; Wellhausen, Nils; Rommel, Philipp C; Baker, Daniel; Suhoski, Megan; Scholler, John; O'Connor, Roddy S; Young, Regina M; Harris, Curtis C; June, Carl H.

Proc Natl Acad Sci U S A ; 121(10): e2317735121, 2024 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-38408246

18.

Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy.

Tang, Yan; Liu, Wei; Kadu, Siddhant; Johnson, Omar; Hasanali, Zainul S; Kelly, Andre; Shestov, Alexander; Pajarillo, Raymone; Greenblatt, Eli; Holmes, Matthew; Wang, Li-Ping; Shih, Natalie; O'Connor, Roddy S; Ruella, Marco; Garfall, Alfred L; Allman, David; Vogl, Dan T; Cohen, Adam; June, Carl H; Sheppard, Neil C.

Blood ; 143(2): 139-151, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-37616575

19.

Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells.

Mai, David; Johnson, Omar; Reff, Jordan; Fan, Ting-Jia; Scholler, John; Sheppard, Neil C; June, Carl H.

Proc Natl Acad Sci U S A ; 120(12): e2218632120, 2023 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-36920923

20.

Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy.

Newman, Haley; Li, Yimei; Liu, Hongyan; Myers, Regina M; Tam, Vicky; DiNofia, Amanda; Wray, Lisa; Rheingold, Susan R; Callahan, Colleen; White, Claire; Baniewicz, Diane; Winestone, Lena E; Kadauke, Stephan; Diorio, Caroline; June, Carl H; Getz, Kelly D; Aplenc, Richard; Teachey, David T; Maude, Shannon L; Grupp, Stephan A; Bona, Kira; Leahy, Allison Barz.

Blood ; 141(6): 609-619, 2023 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-36351239

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