Pesquisa | BVS Violência e Saúde

1.

Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells.

Tran, Cong Si; Kersten, Julia; Yan, Jingyi; Breinig, Marco; Huth, Thorben; Poth, Tanja; Colasanti, Ombretta; Riedl, Tobias; Faure-Dupuy, Suzanne; Diehl, Stefan; Verhoye, Lieven; Li, Teng-Feng; Lingemann, Marit; Schult, Philipp; Ahlén, Gustaf; Frelin, Lars; Kühnel, Florian; Vondran, Florian W R; Breuhahn, Kai; Meuleman, Philip; Heikenwälder, Mathias; Schirmacher, Peter; Bartenschlager, Ralf; Laketa, Vibor; Roessler, Stephanie; Tschaharganeh, Darjus Felix; Sällberg, Matti; Lohmann, Volker.

Gastroenterology ; 2024 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-38636680

2.

Vortex Effects in Merging Black Holes and Saturons.

Dvali, Gia; Kaikov, Oleg; Kühnel, Florian; Valbuena-Bermúdez, Juan Sebastián; Zantedeschi, Michael.

Phys Rev Lett ; 132(15): 151402, 2024 Apr 12.

Artigo em Inglês | MEDLINE | ID: mdl-38683005

3.

The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma.

Kendre, Gajanan; Marhenke, Silke; Lorz, Georgina; Becker, Diana; Reineke-Plaaß, Tanja; Poth, Tanja; Murugesan, Karthikeyan; Kühnel, Florian; Woller, Norman; Wirtz, Ralph M; Pich, Andreas; Marquardt, Jens U; Saborowski, Michael; Vogel, Arndt; Saborowski, Anna.

Hepatology ; 74(3): 1357-1370, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-33709535

4.

Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer.

Ostroumov, Dmitrij; Duong, Steven; Wingerath, Jessica; Woller, Norman; Manns, Michael P; Timrott, Kai; Kleine, Moritz; Ramackers, Wolf; Roessler, Stephanie; Nahnsen, Sven; Czemmel, Stefan; Dittrich-Breiholz, Oliver; Eggert, Tobias; Kühnel, Florian; Wirth, Thomas C.

Hepatology ; 73(4): 1399-1418, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-32716559

5.

MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functions in hepatocellular carcinoma by directly targeting hepatoma-derived growth factor HDGF.

Huge, Nicole; Reinkens, Thea; Buurman, Reena; Sandbothe, Maria; Bergmann, Anke; Wallaschek, Hannah; Vajen, Beate; Stalke, Amelie; Decker, Melanie; Eilers, Marlies; Schäffer, Vera; Dittrich-Breiholz, Oliver; Gürlevik, Engin; Kühnel, Florian; Schlegelberger, Brigitte; Illig, Thomas; Skawran, Britta.

Cancer Cell Int ; 22(1): 192, 2022 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-35578240

6.

Vortices in Black Holes.

Dvali, Gia; Kühnel, Florian; Zantedeschi, Michael.

Phys Rev Lett ; 129(6): 061302, 2022 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-36018670

7.

Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.

Mishra, Amrendra; Emamgholi, Fatemeh; Erlangga, Zulrahman; Hartleben, Björn; Unger, Kristian; Wolff, Katharina; Teichmann, Ulrike; Kessel, Michael; Woller, Norman; Kühnel, Florian; Dow, Lukas E; Manns, Michael P; Vogel, Arndt; Lowe, Scott W; Saborowski, Anna; Saborowski, Michael.

Carcinogenesis ; 41(3): 334-344, 2020 05 14.

Artigo em Inglês | MEDLINE | ID: mdl-31170286

8.

CD4 and CD8 T lymphocyte interplay in controlling tumor growth.

Ostroumov, Dmitrij; Fekete-Drimusz, Nora; Saborowski, Michael; Kühnel, Florian; Woller, Norman.

Cell Mol Life Sci ; 75(4): 689-713, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29032503

9.

Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations.

Wingerath, Jessica; Ostroumov, Dmitrij; Woller, Norman; Manns, Michael P; Pinschewer, Daniel D; Orlinger, Klaus; Berka, Ursula; Kühnel, Florian; Wirth, Thomas C.

Mol Ther ; 25(11): 2533-2545, 2017 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-28803862

10.

The microRNA-449 family inhibits TGF-ß-mediated liver cancer cell migration by targeting SOX4.

Sandbothe, Maria; Buurman, Reena; Reich, Nicole; Greiwe, Luisa; Vajen, Beate; Gürlevik, Engin; Schäffer, Vera; Eilers, Marlies; Kühnel, Florian; Vaquero, Alejandro; Longerich, Thomas; Roessler, Stephanie; Schirmacher, Peter; Manns, Michael P; Illig, Thomas; Schlegelberger, Brigitte; Skawran, Britta.

J Hepatol ; 66(5): 1012-1021, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28088579

11.

Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.

Gürlevik, Engin; Fleischmann-Mundt, Bettina; Brooks, Jennifer; Demir, Ihsan Ekin; Steiger, Katja; Ribback, Silvia; Yevsa, Tetyana; Woller, Norman; Kloos, Arnold; Ostroumov, Dmitrij; Armbrecht, Nina; Manns, Michael P; Dombrowski, Frank; Saborowski, Michael; Kleine, Moritz; Wirth, Thomas C; Oettle, Helmut; Ceyhan, Güralp O; Esposito, Irene; Calvisi, Diego F; Kubicka, Stefan; Kühnel, Florian.

Gastroenterology ; 151(2): 338-350.e7, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27210037

12.

Oncolytic viruses: adenoviruses.

Niemann, Julia; Kühnel, Florian.

Virus Genes ; 53(5): 700-706, 2017 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-28702840

13.

Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses.

Woller, Norman; Gürlevik, Engin; Fleischmann-Mundt, Bettina; Schumacher, Anja; Knocke, Sarah; Kloos, Arnold M; Saborowski, Michael; Geffers, Robert; Manns, Michael P; Wirth, Thomas C; Kubicka, Stefan; Kühnel, Florian.

Mol Ther ; 23(10): 1630-40, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26112079

14.

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.

Brinkhoff, Benjamin; Ostroumov, Dmitrij; Heemcke, Jessica; Woller, Norman; Gürlevik, Engin; Manns, Michael P; Longerich, Thomas; Zender, Lars; Harty, John T; Kubicka, Stefan; Kühnel, Florian; Wirth, Thomas C.

Eur J Immunol ; 44(4): 1213-24, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24338782

15.

Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma.

Gürlevik, Engin; Fleischmann-Mundt, Bettina; Armbrecht, Nina; Longerich, Thomas; Woller, Norman; Kloos, Arnold; Hoffmann, Dirk; Schambach, Axel; Wirth, Thomas C; Manns, Michael P; Zender, Lars; Kubicka, Stefan; Kühnel, Florian.

Hepatology ; 58(3): 1031-41, 2013 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-23686746

16.

Virus infection, inflammation and prevention of cancer.

Woller, Norman; Kühnel, Florian.

Recent Results Cancer Res ; 193: 33-58, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-24008292

17.

Meganuclease-mediated virus self-cleavage facilitates tumor-specific virus replication.

Gürlevik, Engin; Schache, Peter; Goez, Anneliese; Kloos, Arnold; Woller, Norman; Armbrecht, Nina; Manns, Michael P; Kubicka, Stefan; Kühnel, Florian.

Mol Ther ; 21(9): 1738-48, 2013 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-23752311

18.

Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition.

Isermann, Tamara; Schneider, Kim Lucia; Wegwitz, Florian; De Oliveira, Tiago; Conradi, Lena-Christin; Volk, Valery; Feuerhake, Friedrich; Papke, Björn; Stintzing, Sebastian; Mundt, Bettina; Kühnel, Florian; Moll, Ute M; Schulz-Heddergott, Ramona.

bioRxiv ; 2024 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-38464125

19.

Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.

Buurman, Reena; Gürlevik, Engin; Schäffer, Vera; Eilers, Marlies; Sandbothe, Maria; Kreipe, Hans; Wilkens, Ludwig; Schlegelberger, Brigitte; Kühnel, Florian; Skawran, Britta.

Gastroenterology ; 143(3): 811-820.e15, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22641068

20.

Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.

Kirstein, Martha M; Boukouris, Aristeidis E; Pothiraju, Deepika; Buitrago-Molina, Laura E; Marhenke, Silke; Schütt, Jutta; Orlik, Johanna; Kühnel, Florian; Hegermann, Jan; Manns, Michael P; Vogel, Arndt.

Liver Int ; 33(5): 780-93, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23489999

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