Pesquisa | BVS Violência e Saúde

1.

Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression.

Mizrahi, Orel; Nachshon, Aharon; Shitrit, Alina; Gelbart, Idit A; Dobesova, Martina; Brenner, Shirly; Kahana, Chaim; Stern-Ginossar, Noam.

Mol Cell ; 72(5): 862-874.e5, 2018 12 06.

Artigo em Inglês | MEDLINE | ID: mdl-30318442

2.

The antizyme family for regulating polyamines.

Kahana, Chaim.

J Biol Chem ; 293(48): 18730-18735, 2018 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-30355739

3.

Protein degradation, the main hub in the regulation of cellular polyamines.

Kahana, Chaim.

Biochem J ; 473(24): 4551-4558, 2016 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-27941031

4.

Dual Regulatory Role of Polyamines in Adipogenesis.

Brenner, Shirley; Bercovich, Zippi; Feiler, Yulia; Keshet, Rom; Kahana, Chaim.

J Biol Chem ; 290(45): 27384-27392, 2015 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-26396188

5.

Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells.

Landau, Guy; Ran, Avichai; Bercovich, Zippi; Feldmesser, Ester; Horn-Saban, Shirley; Korkotian, Eduard; Jacob-Hirsh, Jasmine; Rechavi, Gideon; Ron, David; Kahana, Chaim.

J Biol Chem ; 287(43): 35825-37, 2012 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-22942278

6.

Antizyme affects cell proliferation and viability solely through regulating cellular polyamines.

Bercovich, Zippi; Snapir, Zohar; Keren-Paz, Alona; Kahana, Chaim.

J Biol Chem ; 286(39): 33778-83, 2011 Sep 30.

Artigo em Inglês | MEDLINE | ID: mdl-21832059

7.

A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.

Paris, Andrew J; Snapir, Zohar; Christopherson, Cindy D; Kwok, Shirley Y; Lee, Ursula E; Ghiassi-Nejad, Zahra; Kocabayoglu, Peri; Sninsky, John J; Llovet, Josep M; Kahana, Chaim; Friedman, Scott L.

Hepatology ; 54(6): 2198-207, 2011 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-21837750

8.

The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.

Landau, Guy; Bercovich, Zippi; Park, Myung Hee; Kahana, Chaim.

J Biol Chem ; 285(17): 12474-81, 2010 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-20181941

9.

Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor.

Kahana, Chaim.

Essays Biochem ; 46: 47-61, 2009 Nov 04.

Artigo em Inglês | MEDLINE | ID: mdl-20095969

10.

Antizyme and antizyme inhibitor, a regulatory tango.

Kahana, Chaim.

Cell Mol Life Sci ; 66(15): 2479-88, 2009 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-19399584

11.

Antizyme 3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation.

Snapir, Zohar; Keren-Paz, Alona; Bercovich, Zippi; Kahana, Chaim.

Biochem J ; 419(1): 99-103, 1 p following 103, 2009 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-19076071

12.

Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance.

Avitan-Hersh, Emily; Feng, Yongmei; Oknin Vaisman, Avital; Abu Ahmad, Yamen; Zohar, Yaniv; Zhang, Tongwu; Lee, Joo Sang; Lazar, Ikrame; Sheikh Khalil, Saeed; Feiler, Yulia; Kluger, Harriet; Kahana, Chaim; Brown, Kevin; Ruppin, Eytan; Ronai, Ze'ev A; Orian, Amir.

J Invest Dermatol ; 140(12): 2466-2477, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32360601

13.

ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1.

Snapir, Zohar; Keren-Paz, Alona; Bercovich, Zippi; Kahana, Chaim.

Biochem J ; 410(3): 613-9, 2008 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-18062773

14.

A Simple Combined Use of CRISPR-Cas9 and Cre-LoxP Technologies for Generating Conditional Gene Knockouts in Mammalian Cells.

Noiman, Tzahi; Kahana, Chaim.

CRISPR J ; 1: 278-285, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-31021220

15.

Cellular localization and phosphorylation of Hrb1p is independent of Sky1p.

Porat, Ziv; Erez, Omri; Kahana, Chaim.

Biochim Biophys Acta ; 1763(2): 207-13, 2006 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-16530282

16.

Cell-free assay for ubiquitin-independent proteasomal protein degradation.

Kahana, Chaim; Reiss, Yuval.

Methods Mol Biol ; 301: 83-96, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-15917628

17.

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

Zwighaft, Ziv; Aviram, Rona; Shalev, Moran; Rousso-Noori, Liat; Kraut-Cohen, Judith; Golik, Marina; Brandis, Alexander; Reinke, Hans; Aharoni, Asaph; Kahana, Chaim; Asher, Gad.

Cell Metab ; 22(5): 874-85, 2015 Nov 03.

Artigo em Inglês | MEDLINE | ID: mdl-26456331

18.

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.

Gandre, Shilpa; Bercovich, Zippi; Kahana, Chaim.

Mitochondrion ; 2(4): 245-56, 2003 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-16120325

19.

Identification, assay, and functional analysis of the antizyme inhibitor family.

Kahana, Chaim.

Methods Mol Biol ; 720: 269-78, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21318879

20.

c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.

Adler, Julia; Reuven, Nina; Kahana, Chaim; Shaul, Yosef.

Mol Cell Biol ; 30(15): 3767-78, 2010 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-20498278

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Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression.

The antizyme family for regulating polyamines.

Protein degradation, the main hub in the regulation of cellular polyamines.

Dual Regulatory Role of Polyamines in Adipogenesis.

Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells.

Antizyme affects cell proliferation and viability solely through regulating cellular polyamines.

A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.

The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongation.

Regulation of cellular polyamine levels and cellular proliferation by antizyme and antizyme inhibitor.

Antizyme and antizyme inhibitor, a regulatory tango.

Antizyme 3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation.

Regulation of eIF2α by RNF4 Promotes Melanoma Tumorigenesis and Therapy Resistance.

ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1.

A Simple Combined Use of CRISPR-Cas9 and Cre-LoxP Technologies for Generating Conditional Gene Knockouts in Mammalian Cells.

Cellular localization and phosphorylation of Hrb1p is independent of Sky1p.

Cell-free assay for ubiquitin-independent proteasomal protein degradation.

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age.

Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons.

Identification, assay, and functional analysis of the antizyme inhibitor family.

c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.