Detalhe da pesquisa
1.
2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.
Proc Natl Acad Sci U S A
; 120(42): e2304139120, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37831739
2.
Effect of N-o-nitrobenzylation on conformation and membrane permeability of linear peptides.
Bioorg Chem
; 145: 107220, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387401
3.
In Vitro and in Vivo Study of a Photostable Quinone Compound with Enhanced Therapeutic Efficacy against Chagas Disease.
Chem Pharm Bull (Tokyo)
; 72(4): 389-392, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38644164
4.
Structure, solubility, and permeability relationships in a diverse middle molecule library.
Bioorg Med Chem Lett
; 37: 127847, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33571648
5.
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Bioorg Med Chem
; 44: 116292, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34225167
6.
[Evaluation of Solubility and Membrane Permeability of Middle-Molecule Compounds Using Artificial Membranes and Living Cells].
Yakugaku Zasshi
; 144(5): 529-537, 2024.
Artigo
em Japonês
| MEDLINE | ID: mdl-38692929
7.
Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent.
Sci Rep
; 14(1): 7628, 2024 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38561454
8.
Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma.
J Med Chem
; 2024 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38670538
9.
Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects.
Drug Metab Dispos
; 41(1): 206-13, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23115085
10.
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.
Nat Commun
; 14(1): 1416, 2023 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36932083
11.
Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties.
ACS Med Chem Lett
; 13(3): 396-402, 2022 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35300080
12.
Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
J Med Chem
; 65(24): 16218-16233, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36472374
13.
Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence.
Life (Basel)
; 11(6)2021 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34205684
14.
Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.
Drug Metab Pharmacokinet
; 32(2): 135-144, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28190755
15.
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
J Pharm Sci
; 106(9): 2566-2575, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28456721
16.
Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.
Drug Metab Pharmacokinet
; 31(6): 395-404, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27745731
17.
Corrigendum to "Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data" [Drug Metab Pharmacokinet 32 (2017) 135-144].
Drug Metab Pharmacokinet
; 32(4): 228, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28587746
18.
Peptide derivation of poorly absorbable drug allows intestinal absorption via peptide transporter.
J Pharm Sci
; 98(5): 1775-87, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18781650