Pesquisa | BVS Violência e Saúde

1.

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.

Zhang, Jidong; Lair, Christine; Roubert, Christine; Amaning, Kwame; Barrio, María Belén; Benedetti, Yannick; Cui, Zhicheng; Xing, Zhongliang; Li, Xiaojun; Franzblau, Scott G; Baurin, Nicolas; Bordon-Pallier, Florence; Cantalloube, Cathy; Sans, Stephanie; Silve, Sandra; Blanc, Isabelle; Fraisse, Laurent; Rak, Alexey; Jenner, Lasse B; Yusupova, Gulnara; Yusupov, Marat; Zhang, Junjie; Kaneko, Takushi; Yang, T J; Fotouhi, Nader; Nuermberger, Eric; Tyagi, Sandeep; Betoudji, Fabrice; Upton, Anna; Sacchettini, James C; Lagrange, Sophie.

Cell ; 186(5): 1013-1025.e24, 2023 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-36827973

2.

Mode-of-action profiling reveals glutamine synthetase as a collateral metabolic vulnerability of M. tuberculosis to bedaquiline.

Wang, Zhe; Soni, Vijay; Marriner, Gwendolyn; Kaneko, Takushi; Boshoff, Helena I M; Barry, Clifton E; Rhee, Kyu Y.

Proc Natl Acad Sci U S A ; 116(39): 19646-19651, 2019 09 24.

Artigo em Inglês | MEDLINE | ID: mdl-31501323

3.

Identification and optimization of a new series of anti-tubercular quinazolinones.

Couturier, Cédric; Lair, Christine; Pellet, Alain; Upton, Anna; Kaneko, Takushi; Perron, Corinne; Cogo, Eric; Menegotto, Jérome; Bauer, Armin; Scheiper, Bodo; Lagrange, Sophie; Bacqué, Eric.

Bioorg Med Chem Lett ; 26(21): 5290-5299, 2016 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-27671498

4.

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.

Wang, Feng; Sambandan, Dhinakaran; Halder, Rajkumar; Wang, Jianing; Batt, Sarah M; Weinrick, Brian; Ahmad, Insha; Yang, Pengyu; Zhang, Yong; Kim, John; Hassani, Morad; Huszar, Stanislav; Trefzer, Claudia; Ma, Zhenkun; Kaneko, Takushi; Mdluli, Khisi E; Franzblau, Scott; Chatterjee, Arnab K; Johnsson, Kai; Johnson, Kai; Mikusova, Katarina; Besra, Gurdyal S; Fütterer, Klaus; Robbins, Scott H; Barnes, S Whitney; Walker, John R; Jacobs, William R; Schultz, Peter G.

Proc Natl Acad Sci U S A ; 110(27): E2510-7, 2013 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-23776209

5.

A novel antimycobacterial compound acts as an intracellular iron chelator.

Dragset, Marte S; Poce, Giovanna; Alfonso, Salvatore; Padilla-Benavides, Teresita; Ioerger, Thomas R; Kaneko, Takushi; Sacchettini, James C; Biava, Mariangela; Parish, Tanya; Argüello, José M; Steigedal, Magnus; Rubin, Eric J.

Antimicrob Agents Chemother ; 59(4): 2256-64, 2015 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-25645825

6.

Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.

Singh, Amrita; Ottavi, Samantha; Krieger, Inna; Planck, Kyle; Perkowski, Andrew; Kaneko, Takushi; Davis, Andrew M; Suh, Christine; Zhang, David; Goullieux, Laurent; Alex, Alexander; Roubert, Christine; Gardner, Mark; Preston, Marian; Smith, Dave M; Ling, Yan; Roberts, Julia; Cautain, Bastien; Upton, Anna; Cooper, Christopher B; Serbina, Natalya; Tanvir, Zaid; Mosior, John; Ouerfelli, Ouathek; Yang, Guangli; Gold, Ben S; Rhee, Kyu Y; Sacchettini, James C; Fotouhi, Nader; Aubé, Jeffrey; Nathan, Carl.

Sci Adv ; 10(11): eadj6406, 2024 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-38489355

7.

Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.

Hwang, Jae-Min; Oh, Taegwon; Kaneko, Takushi; Upton, Anna M; Franzblau, Scott G; Ma, Zhenkun; Cho, Sang-Nae; Kim, Pilho.

J Nat Prod ; 76(3): 354-67, 2013 Mar 22.

Artigo em Inglês | MEDLINE | ID: mdl-23360475

8.

Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis.

Wang, Heng; Bi, Jing; Zhang, Yuan; Pan, Miaomiao; Guo, Qinglong; Xiao, Genhui; Cui, Yumeng; Hu, Song; Chan, Chi Kin; Yuan, Ying; Kaneko, Takushi; Zhang, Guoliang; Chen, Shawn.

ACS Infect Dis ; 8(10): 2019-2027, 2022 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-36048501

9.

The tuberculosis drug discovery and development pipeline and emerging drug targets.

Mdluli, Khisimuzi; Kaneko, Takushi; Upton, Anna.

Cold Spring Harb Perspect Med ; 5(6)2015 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-25635061

10.

Hit and lead criteria in drug discovery for infectious diseases of the developing world.

Katsuno, Kei; Burrows, Jeremy N; Duncan, Ken; Hooft van Huijsduijnen, Rob; Kaneko, Takushi; Kita, Kiyoshi; Mowbray, Charles E; Schmatz, Dennis; Warner, Peter; Slingsby, B T.

Nat Rev Drug Discov ; 14(11): 751-8, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26435527

11.

Tuberculosis drug discovery and emerging targets.

Mdluli, Khisimuzi; Kaneko, Takushi; Upton, Anna.

Ann N Y Acad Sci ; 1323: 56-75, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24920100

12.

Challenges and opportunities in developing novel drugs for TB.

Kaneko, Takushi; Cooper, Christopher; Mdluli, Khisimuzi.

Future Med Chem ; 3(11): 1373-400, 2011 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-21879843

13.

New target for inhibition of bacterial RNA polymerase: 'switch region'.

Srivastava, Aashish; Talaue, Meliza; Liu, Shuang; Degen, David; Ebright, Richard Y; Sineva, Elena; Chakraborty, Anirban; Druzhinin, Sergey Y; Chatterjee, Sujoy; Mukhopadhyay, Jayanta; Ebright, Yon W; Zozula, Alex; Shen, Juan; Sengupta, Sonali; Niedfeldt, Rui Rong; Xin, Cai; Kaneko, Takushi; Irschik, Herbert; Jansen, Rolf; Donadio, Stefano; Connell, Nancy; Ebright, Richard H.

Curr Opin Microbiol ; 14(5): 532-43, 2011 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21862392

14.

Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis.

Ekins, Sean; Kaneko, Takushi; Lipinski, Christopher A; Bradford, Justin; Dole, Krishna; Spektor, Anna; Gregory, Kellan; Blondeau, David; Ernst, Sylvia; Yang, Jeremy; Goncharoff, Nicko; Hohman, Moses M; Bunin, Barry A.

Mol Biosyst ; 6(11): 2316-2324, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20835433

15.

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Magee, Thomas V; Ripp, Sharon L; Li, Bryan; Buzon, Richard A; Chupak, Lou; Dougherty, Thomas J; Finegan, Steven M; Girard, Dennis; Hagen, Anne E; Falcone, Michael J; Farley, Kathleen A; Granskog, Karl; Hardink, Joel R; Huband, Michael D; Kamicker, Barbara J; Kaneko, Takushi; Knickerbocker, Michael J; Liras, Jennifer L; Marra, Andrea; Medina, Ivy; Nguyen, Thuy-Trinh; Noe, Mark C; Obach, R Scott; O'Donnell, John P; Penzien, Joseph B; Reilly, Usa Datta; Schafer, John R; Shen, Yue; Stone, Gregory G; Strelevitz, Timothy J; Sun, Jianmin; Tait-Kamradt, Amelia; Vaz, Alfin D N; Whipple, David A; Widlicka, Daniel W; Wishka, Donn G; Wolkowski, Joanna P; Flanagan, Mark E.

J Med Chem ; 52(23): 7446-57, 2009 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-19775168

16.

Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides.

Kaneko, Takushi; McMillen, William; Lynch, Meghan Keaney.

Bioorg Med Chem Lett ; 17(18): 5013-8, 2007 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-17692517

17.

Novel tethers in ketolide antibiotics.

Kaneko, Takushi; Romero, Karina; Li, Bryan; Buzon, Richard.

Bioorg Med Chem Lett ; 17(18): 5049-53, 2007 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-17659873

18.

Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles.

Boyer, Frederick E; Vara Prasad, J V N; Choy, Allison L; Chupak, Louis; Dermyer, Michael R; Ding, Qizhu; Huband, Michael D; Jiao, Wenhua; Kaneko, Takushi; Khlebnikov, Vladimir; Kim, Ji-Young; Lall, Manjinder S; Maiti, Samarendra N; Romero, Karina; Wu, Xiujuan.

Bioorg Med Chem Lett ; 17(16): 4694-8, 2007 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-17590334

19.

Drugs for neglected diseases: part I.

Kaneko, Takushi.

Future Med Chem ; 3(10): 1235-7, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21859296

20.

Drugs for neglected diseases: part II.