Detalhe da pesquisa
1.
A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
J Neurosci
; 30(33): 11157-66, 2010 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20720123
2.
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Bioorg Med Chem
; 19(18): 5539-52, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21856163
3.
T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.
Eur J Pharmacol
; 438(3): 129-35, 2002 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11909603
4.
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
J Med Chem
; 55(5): 2353-66, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22309223
5.
Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aß peptide levels and impaired learning behavior in aged rats.
Brain Res
; 1361: 146-56, 2010 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20849831