Pesquisa | BVS Violência e Saúde

1.

Estrogen receptor gets a grip on RNA.

Katzenellenbogen, Benita S.

Cell ; 184(20): 5086-5088, 2021 09 30.

Artigo em Inglês | MEDLINE | ID: mdl-34559987

2.

Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu.

Min, Charles K; Nwachukwu, Jerome C; Hou, Yingwei; Russo, Robin J; Papa, Alexandra; Min, Jian; Peng, Rouming; Kim, Sung Hoon; Ziegler, Yvonne; Rangarajan, Erumbi S; Izard, Tina; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Nettles, Kendall W.

Proc Natl Acad Sci U S A ; 121(24): e2321344121, 2024 Jun 11.

Artigo em Inglês | MEDLINE | ID: mdl-38830107

3.

Dual-mechanism estrogen receptor inhibitors.

Min, Jian; Nwachukwu, Jerome C; Min, Charles K; Njeri, Jacqline W; Srinivasan, Sathish; Rangarajan, Erumbi S; Nettles, Charles C; Sanabria Guillen, Valeria; Ziegler, Yvonne; Yan, Shunchao; Carlson, Kathryn E; Hou, Yingwei; Kim, Sung Hoon; Novick, Scott; Pascal, Bruce D; Houtman, Rene; Griffin, Patrick R; Izard, Tina; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Nettles, Kendall W.

Proc Natl Acad Sci U S A ; 118(35)2021 08 31.

Artigo em Inglês | MEDLINE | ID: mdl-34452998

4.

Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer.

Katzenellenbogen, Benita S; Guillen, Valeria Sanabria; Katzenellenbogen, John A.

Breast Cancer Res ; 25(1): 76, 2023 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-37370117

5.

Effective combination treatments for breast cancer inhibition by FOXM1 inhibitors with other targeted cancer drugs.

Guillen, Valeria Sanabria; Ziegler, Yvonne; Gopinath, Chirag; Kumar, Sandeep; Dey, Parama; Plotner, Blake N; Dawson, Nadia Z; Kim, Sung Hoon; Katzenellenbogen, John A; Katzenellenbogen, Benita S.

Breast Cancer Res Treat ; 198(3): 607-621, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36847915

6.

Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer.

Yan, Shunchao; Dey, Parama; Ziegler, Yvonne; Jiao, Xin; Kim, Sung Hoon; Katzenellenbogen, John A; Katzenellenbogen, Benita S.

Breast Cancer Res Treat ; 185(2): 281-292, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33001337

7.

Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors.

Laws, Mary J; Ziegler, Yvonne; Shahoei, Sayyed Hamed; Dey, Parama; Kim, Sung Hoon; Yasuda, Mayuri; Park, Ben Ho; Nettles, Kendall W; Katzenellenbogen, John A; Nelson, Erik R; Katzenellenbogen, Benita S.

Breast Cancer Res Treat ; 181(2): 297-307, 2020 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-32277377

8.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan, Sathish; Nwachukwu, Jerome C; Bruno, Nelson E; Dharmarajan, Venkatasubramanian; Goswami, Devrishi; Kastrati, Irida; Novick, Scott; Nowak, Jason; Cavett, Valerie; Zhou, Hai-Bing; Boonmuen, Nittaya; Zhao, Yuechao; Min, Jian; Frasor, Jonna; Katzenellenbogen, Benita S; Griffin, Patrick R; Katzenellenbogen, John A; Nettles, Kendall W.

Nat Chem Biol ; 13(1): 111-118, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27870835

9.

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

Menazza, Sara; Sun, Junhui; Appachi, Swathi; Chambliss, Ken L; Kim, Sung Hoon; Aponte, Angel; Khan, Sohaib; Katzenellenbogen, John A; Katzenellenbogen, Benita S; Shaul, Philip W; Murphy, Elizabeth.

J Mol Cell Cardiol ; 107: 41-51, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28457941

10.

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

Smirnova, Natalia F; Fontaine, Coralie; Buscato, Mélissa; Lupieri, Adrien; Vinel, Alexia; Valera, Marie-Cécile; Guillaume, Maeva; Malet, Nicole; Foidart, Jean-Michel; Raymond-Letron, Isabelle; Lenfant, Francoise; Gourdy, Pierre; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Laffargue, Muriel; Arnal, Jean-Francois.

Circ Res ; 117(9): 770-8, 2015 Oct 09.

Artigo em Inglês | MEDLINE | ID: mdl-26316608

11.

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.

Aumsuwan, Pranapda; Khan, Shabana I; Khan, Ikhlas A; Ali, Zulfiqar; Avula, Bharathi; Walker, Larry A; Shariat-Madar, Zia; Helferich, William G; Katzenellenbogen, Benita S; Dasmahapatra, Asok K.

Arch Biochem Biophys ; 591: 98-110, 2016 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-26682631

12.

Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.

Kim, Sung Hoon; Madak-Erdogan, Zeynep; Bae, Sung Chul; Carlson, Kathryn E; Mayne, Christopher G; Granick, Steve; Katzenellenbogen, Benita S; Katzenellenbogen, John A.

J Am Chem Soc ; 137(32): 10326-35, 2015 Aug 19.

Artigo em Inglês | MEDLINE | ID: mdl-26186415

13.

The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells.

Bergamaschi, Anna; Madak-Erdogan, Zeynep; Kim, Yu Jin; Choi, Yoon-La; Lu, Hailing; Katzenellenbogen, Benita S.

Breast Cancer Res ; 16(5): 436, 2014 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-25213081

14.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and ß, and their coregulators.

Madak-Erdogan, Zeynep; Charn, Tze-Howe; Jiang, Yan; Liu, Edison T; Katzenellenbogen, John A; Katzenellenbogen, Benita S.

Mol Syst Biol ; 9: 676, 2013 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-23774759

15.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan, Sathish; Nwachukwu, Jerome C; Bruno, Nelson E; Dharmarajan, Venkatasubramanian; Goswami, Devrishi; Kastrati, Irida; Novick, Scott; Nowak, Jason; Cavett, Valerie; Zhou, Hai-Bing; Boonmuen, Nittaya; Zhao, Yuechao; Min, Jian; Frasor, Jonna; Katzenellenbogen, Benita S; Griffin, Patrick R; Katzenellenbogen, John A; Nettles, Kendall W.

Nat Chem Biol ; 13(6): 691, 2017 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-28514419

16.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Srinivasan, Sathish; Nwachukwu, Jerome C; Bruno, Nelson E; Dharmarajan, Venkatasubramanian; Goswami, Devrishi; Kastrati, Irida; Novick, Scott; Nowak, Jason; Cavett, Valerie; Zhou, Hai-Bing; Boonmuen, Nittaya; Zhao, Yuechao; Min, Jian; Frasor, Jonna; Katzenellenbogen, Benita S; Griffin, Patrick R; Katzenellenbogen, John A; Nettles, Kendall W.

Nat Chem Biol ; 13(6): 691, 2017 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-28514424

17.

Mechanisms enforcing the estrogen receptor ß selectivity of botanical estrogens.

Jiang, Yan; Gong, Ping; Madak-Erdogan, Zeynep; Martin, Teresa; Jeyakumar, Muthu; Carlson, Kathryn; Khan, Ikhlas; Smillie, Troy J; Chittiboyina, Amar G; Rotte, Sateesh C K; Helferich, William G; Katzenellenbogen, John A; Katzenellenbogen, Benita S.

FASEB J ; 27(11): 4406-18, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23882126

18.

NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells.

Liu, Cassie; Vorderbruggen, Makenzie; Muñoz-Trujillo, Catalina; Kim, Sung Hoon; Katzenellenbogen, John A; Katzenellenbogen, Benita S; Karpf, Adam R.

J Ovarian Res ; 17(1): 94, 2024 May 04.

Artigo em Inglês | MEDLINE | ID: mdl-38704607

19.

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu.

Min, Charles K; Nwachukwu, Jerome C; Hou, Yingwei; Russo, Robin J; Papa, Alexandra; Min, Jian; Peng, Rouming; Kim, Sung Hoon; Ziegler, Yvonne; Rangarajan, Erumbi S; Izard, Tina; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Nettles, Kendall W.

bioRxiv ; 2024 Apr 13.

Artigo em Inglês | MEDLINE | ID: mdl-38645081

20.

Reprogramming of endothelial gene expression by tamoxifen inhibits angiogenesis and ERα-negative tumor growth.

Fébrissy, Chanaëlle; Adlanmerini, Marine; Péqueux, Christel; Boudou, Frédéric; Buscato, Mélissa; Gargaros, Adrien; Gilardi-Bresson, Silveric; Boriak, Khrystyna; Laurell, Henrik; Fontaine, Coralie; Katzenellenbogen, Benita S; Katzenellenbogen, John A; Guillermet-Guibert, Julie; Arnal, Jean-François; Metivier, Raphaël; Lenfant, Françoise.

Theranostics ; 14(1): 249-264, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38164151

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Estrogen receptor gets a grip on RNA.

Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu.

Dual-mechanism estrogen receptor inhibitors.

Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer.

Effective combination treatments for breast cancer inhibition by FOXM1 inhibitors with other targeted cancer drugs.

Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer.

Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors.

Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells.

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro.

Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.

The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and ß, and their coregulators.

Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

Mechanisms enforcing the estrogen receptor ß selectivity of botanical estrogens.

NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells.

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu.

Reprogramming of endothelial gene expression by tamoxifen inhibits angiogenesis and ERα-negative tumor growth.