Detalhe da pesquisa
1.
Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.
Cell
; 141(5): 799-811, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20510927
2.
Interferon regulatory factor 5 (IRF5) suppresses hepatitis C virus (HCV) replication and HCV-associated hepatocellular carcinoma.
J Biol Chem
; 292(52): 21676-21689, 2017 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-29079574
3.
Nonstructural protein 5B promotes degradation of the NORE1A tumor suppressor to facilitate hepatitis C virus replication.
Hepatology
; 65(5): 1462-1477, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28090674
4.
Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors.
Biochem Biophys Res Commun
; 469(3): 743-7, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26697747
5.
Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles.
J Enzyme Inhib Med Chem
; 30(5): 778-85, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25676325
6.
Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Arch Pharm (Weinheim)
; 348(1): 10-22, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25449674
7.
Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation.
J Chem Inf Model
; 54(10): 2876-86, 2014 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25254429
8.
Multiple e-pharmacophore modeling, 3D-QSAR, and high-throughput virtual screening of hepatitis C virus NS5B polymerase inhibitors.
J Chem Inf Model
; 54(2): 539-52, 2014 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24460140
9.
Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.
Bioorg Med Chem
; 21(11): 3127-37, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23608107
10.
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem
; 21(11): 3262-71, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23598249
11.
Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.
Arch Pharm (Weinheim)
; 346(2): 140-53, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23280502
12.
Synthesis and characterization of celecoxib derivatives as possible anti-inflammatory, analgesic, antioxidant, anticancer and anti-HCV agents.
Molecules
; 18(3): 3595-614, 2013 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23519201
13.
Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture.
PLoS Pathog
; 6(5): e1000910, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20502631
14.
The glutamine side chain at position 91 on the ß5a-ß5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.
Biochemistry
; 50(37): 8067-77, 2011 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21800837
15.
Combining 3-D quantitative structure-activity relationship with ligand based and structure based alignment procedures for in silico screening of new hepatitis C virus NS5B polymerase inhibitors.
J Chem Inf Model
; 50(4): 662-76, 2010 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20225870
16.
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Bioorg Med Chem
; 18(13): 4630-8, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20627595
17.
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.
Nucleic Acids Res
; 36(5): 1482-96, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18203743
18.
4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors.
Front Biosci
; 13: 3857-68, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18508480
19.
Peptide inhibition of HIV-1: current status and future potential.
BioDrugs
; 22(3): 161-75, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18481899
20.
Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.
Bioorg Med Chem Lett
; 18(23): 6110-4, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18947995