Detalhe da pesquisa
1.
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Biochem Biophys Res Commun
; 523(3): 795-801, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31954521
2.
Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators.
Bioorg Med Chem Lett
; 29(6): 815-820, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30704812
3.
Pharmacological characterization of synthetic serine palmitoyltransferase inhibitors by biochemical and cellular analyses.
Biochem Biophys Res Commun
; 497(4): 1171-1176, 2018 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28042036
4.
Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.
Bioorg Med Chem
; 26(3): 647-660, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29291937
5.
Discovery of a novel prolyl-tRNA synthetase inhibitor and elucidation of its binding mode to the ATP site in complex with l-proline.
Biochem Biophys Res Commun
; 488(2): 393-399, 2017 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28501621
6.
Identification of AHCY inhibitors using novel high-throughput mass spectrometry.
Biochem Biophys Res Commun
; 491(1): 1-7, 2017 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533090
7.
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem Biophys Res Commun
; 486(3): 626-631, 2017 05 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28315326
8.
Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.
Bioorg Med Chem Lett
; 27(5): 1311-1315, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169164
9.
Discovery of spiro[indole-3,2'-pyrrolidin]-2(1H)-one based inhibitors targeting Brr2, a core component of the U5 snRNP.
Bioorg Med Chem
; 25(17): 4753-4767, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28751196
10.
Discovery of selective ATP-competitive eIF4A3 inhibitors.
Bioorg Med Chem
; 25(7): 2200-2209, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283335
11.
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E.
Bioorg Med Chem Lett
; 26(17): 4296-300, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27476141
12.
Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Bioorg Med Chem Lett
; 23(6): 1779-85, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23414845
13.
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg Med Chem Lett
; 23(12): 3662-6, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664874
14.
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem
; 21(17): 5488-502, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23816042
15.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7326-9, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23147077
16.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22883026
17.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22763369
18.
Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.
Bioorg Med Chem
; 19(6): 1881-94, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353570
19.
A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice.
Sci Rep
; 11(1): 15423, 2021 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326423
20.
Identification of the first highly selective inhibitor of human lactate dehydrogenase B.
Sci Rep
; 11(1): 21353, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34725423