Detalhe da pesquisa
1.
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.
Pharmacol Res
; 201: 107092, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38311014
2.
Beyond VEGF: Targeting Inflammation and Other Pathways for Treatment of Retinal Disease.
J Pharmacol Exp Ther
; 386(1): 15-25, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142441
3.
Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells.
Int J Mol Sci
; 24(2)2023 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36674619
4.
Molecular Targets to Alleviate Enteric Neuropathy and Gastrointestinal Dysfunction.
Adv Exp Med Biol
; 1383: 221-228, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36587161
5.
Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons.
Int J Mol Sci
; 23(3)2022 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163831
6.
Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.
J Cell Mol Med
; 25(2): 784-800, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33274592
7.
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.
Br J Cancer
; 124(9): 1566-1580, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33658640
8.
Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy.
Int J Mol Sci
; 22(19)2021 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34638620
9.
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
J Biol Chem
; 294(13): 5198-5207, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30705092
10.
Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.
J Pharmacol Exp Ther
; 367(1): 108-118, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30076264
11.
Correction: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours.
Br J Cancer
; 127(7): 1378-1379, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35953714
12.
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.
J Biol Chem
; 290(5): 3057-68, 2015 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25492865
13.
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.
J Pharmacol Exp Ther
; 359(2): 300-309, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27608656
14.
Targeting DNA repair pathways for cancer treatment: what's new?
Future Oncol
; 10(7): 1215-37, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24947262
15.
Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 106-117, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884051
16.
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.
Biochemistry
; 52(17): 2955-66, 2013 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23597102
17.
APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease.
Biomolecules
; 13(11)2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38002251
18.
Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1.
bioRxiv
; 2023 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37425839
19.
Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment.
Front Med (Lausanne)
; 10: 1146115, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37181357
20.
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue.
Genes Dis
; 10(1): 267-283, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37013054