Pesquisa | BVS Violência e Saúde

1.

Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria.

Peffault de Latour, Régis; Röth, Alexander; Kulasekararaj, Austin G; Han, Bing; Scheinberg, Phillip; Maciejewski, Jaroslaw P; Ueda, Yasutaka; de Castro, Carlos M; Di Bona, Eros; Fu, Rong; Zhang, Li; Griffin, Morag; Langemeijer, Saskia M C; Panse, Jens; Schrezenmeier, Hubert; Barcellini, Wilma; Mauad, Vitor A Q; Schafhausen, Philippe; Tavitian, Suzanne; Beggiato, Eloise; Chew, Lee Ping; Gaya, Anna; Huang, Wei-Han; Jang, Jun Ho; Kitawaki, Toshio; Kutlar, Abdullah; Notaro, Rosario; Pullarkat, Vinod; Schubert, Jörg; Terriou, Louis; Uchiyama, Michihiro; Wong Lee Lee, Lily; Yap, Eng-Soo; Sicre de Fontbrune, Flore; Marano, Luana; Alashkar, Ferras; Gandhi, Shreyans; Trikha, Roochi; Yang, Chen; Liu, Hui; Kelly, Richard J; Höchsmann, Britta; Kerloeguen, Cécile; Banerjee, Partha; Levitch, Rafael; Kumar, Rakesh; Wang, Zhixin; Thorburn, Christine; Maitra, Samopriyo; Li, Shujie.

N Engl J Med ; 390(11): 994-1008, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38477987

2.

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria.

Kelly, Richard J; Holt, Matthew; Vidler, Jennifer; Arnold, Louise M; Large, Joanna; Forrest, Briony; Barnfield, Catherine; Pike, Alexandra; Griffin, Morag; Munir, Talha; Muus, Petra; Nagumantry, Sateesh K; Varghese, Abraham; Davies, John R; Trikha, Roochi; Kulasekararaj, Austin G; Mitchell, Lindsay; Gandhi, Shreyans.

Blood ; 143(12): 1157-1166, 2024 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-38142401

3.

Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition.

Röth, Alexander; He, Guangsheng; Tong, Hongyan; Lin, Zenghua; Wang, Xiaoqin; Chai-Adisaksopha, Chatree; Lee, Je-Hwan; Brodsky, Andres; Hantaweepant, Chattree; Dumagay, Teresita E; Demichelis-Gómez, Roberta; Rojnuckarin, Ponlapat; Sun, Jing; Höglund, Martin; Jang, Jun Ho; Gaya, Anna; Silva, Fernando; Obara, Naoshi; Kelly, Richard J; Beveridge, Leigh; Buatois, Simon; Chebon, Sammy; Gentile, Brittany; Lundberg, Pontus; Sreckovic, Sasha; Nishimura, Jun-Ichi; Risitano, Antonio; Han, Bing.

Am J Hematol ; 2024 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-38884175

4.

A phase 1b study of venetoclax and alvocidib in patients with relapsed/refractory acute myeloid leukemia.

Jonas, Brian A; Hou, Jing-Zhou; Roboz, Gail J; Alvares, Caroline L; Jeyakumar, Deepa; Edwards, John R; Erba, Harry P; Kelly, Richard J; Röllig, Christoph; Fiedler, Walter; Brackman, Deanna; Siddani, Satya R; Chyla, Brenda; Hilger-Rolfe, Jacqueline; Watts, Justin M.

Hematol Oncol ; 41(4): 743-752, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37086447

5.

Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria.

Kelly, Richard J; Höchsmann, Britta; Szer, Jeff; Kulasekararaj, Austin; de Guibert, Sophie; Röth, Alexander; Weitz, Ilene C; Armstrong, Elina; Risitano, Antonio M; Patriquin, Christopher J; Terriou, Louis; Muus, Petra; Hill, Anita; Turner, Michelle P; Schrezenmeier, Hubert; Peffault de Latour, Regis.

N Engl J Med ; 373(11): 1032-9, 2015 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-26352814

6.

A Comparison of Walking Gait Following Mechanical and Kinematic Alignment in Total Knee Joint Replacement.

McNair, Peter J; Boocock, Mark G; Dominick, Nicholas D; Kelly, Richard J; Farrington, Bill J; Young, Simon W.

J Arthroplasty ; 33(2): 560-564, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29054726

7.

Thrombosis in paroxysmal nocturnal hemoglobinuria.

Hill, Anita; Kelly, Richard J; Hillmen, Peter.

Blood ; 121(25): 4985-96; quiz 5105, 2013 Jun 20.

Artigo em Inglês | MEDLINE | ID: mdl-23610373

8.

Altered natural killer cell subset homeostasis and defective chemotactic responses in paroxysmal nocturnal hemoglobinuria.

El-Sherbiny, Yasser M; Kelly, Richard J; Hill, Anita; Doody, Gina M; Hillmen, Peter; Cook, Graham P.

Blood ; 122(11): 1887-90, 2013 Sep 12.

Artigo em Inglês | MEDLINE | ID: mdl-23881915

9.

Thrombosis and meningococcal infection rates in pegcetacoplan-treated patients with paroxysmal nocturnal hemoglobinuria in the clinical trial and postmarketing settings.

Kelly, Richard J; Nishimori, Hisakazu; Horneff, Regina; Hillmen, Peter; Al-Adhami, Mohammed; Lallier, Stacie; Gerber, Gloria F.

Res Pract Thromb Haemost ; 8(4): 102416, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38812989

10.

Management of acute breakthrough hemolysis with intensive pegcetacoplan dosing in patients with PNH.

Griffin, Morag; Kelly, Richard J; Panse, Jens; de Castro, Carlos; Szer, Jeff; Horneff, Regina; Tan, Lisa; Yeh, Michael; Peffault de Latour, Régis.

Blood Adv ; 8(7): 1776-1786, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38315872

11.

Hemolysis events in the phase 3 PEGASUS study of pegcetacoplan in patients with paroxysmal nocturnal hemoglobinuria.

Peffault de Latour, Régis; Griffin, Morag; Kelly, Richard J; Szer, Jeff; de Castro, Carlos; Horneff, Regina; Tan, Lisa; Yeh, Michael; Panse, Jens.

Blood Adv ; 8(11): 2718-2725, 2024 Jun 11.

Artigo em Inglês | MEDLINE | ID: mdl-38593241

12.

Safety and Efficacy of Pegcetacoplan in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria over 48 Weeks: 307 Open-Label Extension Study.

Patriquin, Christopher J; Bogdanovic, Andrija; Griffin, Morag; Kelly, Richard J; Maciejewski, Jaroslaw P; Mulherin, Brian; Peffault de Latour, Régis; Röth, Alexander; Selvaratnam, Veena; Szer, Jeffrey; Al-Adhami, Mohammed; Horneff, Regina; Tan, Lisa; Yeh, Michael; Panse, Jens.

Adv Ther ; 41(5): 2050-2069, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38573482

13.

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

Kelly, Richard J; Hill, Anita; Arnold, Louise M; Brooksbank, Gemma L; Richards, Stephen J; Cullen, Matthew; Mitchell, Lindsay D; Cohen, Dena R; Gregory, Walter M; Hillmen, Peter.

Blood ; 117(25): 6786-92, 2011 Jun 23.

Artigo em Inglês | MEDLINE | ID: mdl-21460245

14.

Natural killer (NK) cell function in paroxysmal nocturnal hemoglobinuria: a deficiency of NK cells, but not an NK cell deficiency.

El-Sherbiny, Yasser M; Doody, Gina M; Kelly, Richard J; Hill, Anita; Hillmen, Peter; Cook, Graham P.

Blood ; 125(8): 1351-2, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25700426

15.

The cost-effectiveness, of pegcetacoplan compared with ravulizumab for the treatment of paroxysmal nocturnal hemoglobinuria, in a UK setting.

Hakimi, Zalmai; Wilson, Koo; McAughey, Eoin; Pochopien, Michal; Wojciechowski, Piotr; Toumi, Mondher; Knight, Chris; Sarda, Sujata P; Patel, Nikita; Wiseman, Catherine; de Castro, Nuno Pinto; Nazir, Jameel; Kelly, Richard J.

J Comp Eff Res ; 11(13): 969-985, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35796199

16.

Helm's Alee: Setting a New Course.

Kelly, Richard J.

J Leg Med ; 36(2): 101-2, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-27128334

17.

Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21.

Müller, Louise M E; Holmes, Matthew; Michael, Joanne L; Scott, Gina B; West, Emma J; Scott, Karen J; Parrish, Christopher; Hall, Kathryn; Stäble, Sina; Jennings, Victoria A; Cullen, Matthew; McConnell, Stewart; Langton, Catherine; Tidswell, Emma L; Shafren, Darren; Samson, Adel; Harrington, Kevin J; Pandha, Hardev; Ralph, Christy; Kelly, Richard J; Cook, Gordon; Melcher, Alan A; Errington-Mais, Fiona.

J Immunother Cancer ; 7(1): 164, 2019 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-31262361

18.

COVID-19 vaccination antibody responses in patients with aplastic anaemia and paroxysmal nocturnal haemoglobinuria.

Pike, Alexandra; McKinley, Claire; Forrest, Briony; Scott, Rebecca; Charlton, Emily; Scott, Emma; Zhakata, Tapiwa; Harland, Mark; Clarke, Deborah; Davies, John R; Toogood, Aurora; Houghton, Nicola; Youngs, Nora; Barnfield, Catherine; Richards, Stephen; Payne, Daniel; Arnold, Louise; Munir, Tahla; Muus, Petra; Griffin, Morag; Kelly, Richard J; Hillmen, Peter; Newton, Darren.

Lancet Haematol ; 9(8): e553-e556, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35780797

19.

Outcome of Azacitidine Therapy in Acute Myeloid Leukemia Is not Improved by Concurrent Vorinostat Therapy but Is Predicted by a Diagnostic Molecular Signature.

Craddock, Charles F; Houlton, Aimee E; Quek, Lynn Swun; Ferguson, Paul; Gbandi, Emma; Roberts, Corran; Metzner, Marlen; Garcia-Martin, Natalia; Kennedy, Alison; Hamblin, Angela; Raghavan, Manoj; Nagra, Sandeep; Dudley, Louise; Wheatley, Keith; McMullin, Mary Frances; Pillai, Srinivas P; Kelly, Richard J; Siddique, Shamyla; Dennis, Michael; Cavenagh, Jamie D; Vyas, Paresh.

Clin Cancer Res ; 23(21): 6430-6440, 2017 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-28765326

20.

Total asymmetric synthesis of sperabillins B and D.

Davies, Stephen G; Kelly, Richard J; Mortimer, Anne J Price.

Chem Commun (Camb) ; (17): 2132-3, 2003 Sep 07.

Artigo em Inglês | MEDLINE | ID: mdl-13678166

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