Detalhe da pesquisa
1.
Analyzing Kinase Similarity in Small Molecule and Protein Structural Space to Explore the Limits of Multi-Target Screening.
Molecules
; 26(3)2021 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33530327
2.
Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer.
Angew Chem Int Ed Engl
; 57(9): 2307-2313, 2018 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29178586
3.
Monitoring Conformational Changes in the Receptor Tyrosine Kinase EGFR.
Chembiochem
; 17(11): 990-4, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26991964
4.
Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR.
Angew Chem Int Ed Engl
; 55(36): 10909-12, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496389
5.
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
J Med Chem
; 65(9): 6643-6655, 2022 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486541
6.
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
J Med Chem
; 63(20): 11725-11755, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32931277
7.
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Chem Sci
; 10(46): 10789-10801, 2019 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31857889
8.
RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics.
ChemMedChem
; 13(19): 2065-2072, 2018 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30079978
9.
Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors.
Nat Commun
; 9(1): 4655, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30405134
10.
Characterization of Covalent-Reversible EGFR Inhibitors.
ACS Omega
; 2(4): 1563-1575, 2017 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29963651
11.
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
J Med Chem
; 60(6): 2361-2372, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28225269
12.
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT.
J Med Chem
; 60(21): 8801-8815, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28991465
13.
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
J Med Chem
; 60(13): 5613-5637, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28603991
14.
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
J Med Chem
; 60(18): 7725-7744, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853575
15.
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Sci Transl Med
; 9(394)2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28615362
16.
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J Med Chem
; 58(17): 6844-63, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275028