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1.
BMC Cancer ; 22(1): 25, 2022 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-34980013

RESUMO

BACKGROUND: Lower limb lymphedema (LLL) is one of the most refractory and debilitating complications related to gynecological cancer treatment. We investigated factors associated with response to compression-based physical therapy (CPT) for secondary LLL after gynecologic cancer treatment. METHODS: We performed a multicenter retrospective study using the records of seven medical institutions from 2002 and 2014. Patients who developed LLL after gynecological cancer treatment were included. Limb volumes were calculated from the lengths of the limb circumferences at four points. All participants underwent compression-based physical therapy for LLL. Factors, including MLD, indicative of circumference reductions in LLL were determined. RESULTS: In total, 1,034 LLL met the required criteria of for the study. A multivariate linear regression analysis identified age; body mass index (BMI); endometrial cancer; radiotherapy; and initial limb circumference as significant independent prognostic factors related to improvement in LLL. In analysis of covariance for improvement in LLL adjusted by the initial limb circumference and stratified by BMI and radiotherapy, patients with BMI 28 kg/m2 or higher and receiving radiation rarely responded to CPT. CONCLUSIONS: Improvements in the lower limb circumference correlated with clinical histories and physical characteristics, which may be used as independent prognostic factors for successful CPT for LLL after gynecological cancer treatment.


Assuntos
Bandagens Compressivas , Neoplasias dos Genitais Femininos/fisiopatologia , Linfedema/terapia , Modalidades de Fisioterapia , Complicações Pós-Operatórias/terapia , Idoso , Índice de Massa Corporal , Feminino , Neoplasias dos Genitais Femininos/cirurgia , Humanos , Modelos Lineares , Extremidade Inferior/fisiopatologia , Excisão de Linfonodo/efeitos adversos , Linfedema/etiologia , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Prognóstico , Radioterapia , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
2.
Support Care Cancer ; 24(2): 637-646, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26105516

RESUMO

PURPOSE: Cancer-related fatigue (CRF) is one of the most common symptoms reported by cancer patients. This randomized trial investigated the efficacy of the amino acid jelly Inner Power(®) (IP), a semi-solid, orally administrable dietary supplement containing coenzyme Q10 and L-carnitine, in controlling CRF in breast cancer patients in Japan. METHODS: Breast cancer patients with CRF undergoing chemotherapy were randomly assigned to receive IP once daily or regular care for 21 days. The primary endpoint was the change in the worst level of fatigue during the past 24 h (Brief Fatigue Inventory [BFI] item 3 score) from day 1 (baseline) to day 22. Secondary endpoints were change in global fatigue score (GFS; the average of all BFI items), anxiety and depression assessed by the Hospital Anxiety and Depression Scale (HADS), quality of life assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and EORTC Breast Cancer-Specific QLQ (EORTC QLQ-BR23), and adverse events. RESULTS: Fifty-nine patients were enrolled in the study, of whom 57 were included in the efficacy analysis. Median patient age was 50 years. Changes in the worst level of fatigue, GFS, and current feeling of fatigue were significantly different between the intervention and control groups, whereas the change in the average feeling of fatigue was not significantly different between groups. HADS, EORTC QLQ-C30, and EORTC QLQ-BR23 scores were not significantly different between the two groups. No severe adverse events were observed. CONCLUSION: IP may control moderate-severe CRF in breast cancer patients. TRIAL REGISTRATION: The registration number of this study in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) is UMIN000008646.


Assuntos
Neoplasias da Mama/fisiopatologia , Carnitina/administração & dosagem , Fadiga/tratamento farmacológico , Ubiquinona/análogos & derivados , Adulto , Idoso , Neoplasias da Mama/tratamento farmacológico , Fadiga/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Qualidade de Vida , Ubiquinona/administração & dosagem
3.
Gan To Kagaku Ryoho ; 41(1): 7-10, 2014 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-24423945

RESUMO

Lymphedema is divided into primary lymphedema due to inherited conditions, and secondary lymphedema arising from damage to the lymph nodes or vessels. The main cause of secondary lymphedema in Japan is cancer treatment such as lymph node dissection and/or irradiation. However, surgeons are not often interested in this non-fatal aftereffect of surgery. Therefore, there has been little research with a high level of evidence to reach a better evidence-based medicine(EBM)or understanding of the real incidence of lymphedema. Because of the delay of standardization of management, prophylactic instruction against lymphedema and the use of elastic garments and bandaging for the treatment of lymphedema have been covered by medical reimbursement since 2008. Doctors must now pay attention to the management of postoperative lymphedema. Prophylactic instructions are given to doctors, nurses, and physical therapists so that they may teach the prescribed points to patients independently. These medical staff are also supposed to be in charge of the treatment of lymphedema patients; however, only the costs of compression materials have been reimbursed as of 2013. A standard strategy based on the EBM should be performed as a team practice. A comprehensive program including lymphedema management is also introduced.


Assuntos
Linfedema/terapia , Equipe de Assistência ao Paciente , Complicações Pós-Operatórias/terapia , Medicina Baseada em Evidências , Humanos , Excisão de Linfonodo/efeitos adversos , Linfedema/etiologia , Guias de Prática Clínica como Assunto
4.
Lymphat Res Biol ; 20(5): 539-547, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-34981970

RESUMO

Background: Secondary lymphedema mostly occurs as an aftereffect of cancer treatment, and it is estimated that 100,000-150,000 patients are affected in Japan. An estimated 3500 patients, develop lymphedema of the lower and upper extremities each year secondary to uterine and breast cancer treatment. Medical reimbursement was first instituted in April 2008 by the Ministry of Health, Labour and Welfare in Japan. Since 2008, we have developed guidelines regarding treatment options for patients with lymphedema based on scientific evidence. This is the third edition of the guidelines established by the Japanese Lymphedema Society (JLES), published in 2018. The JLES Practice Guideline-Making Committee (PGMC) developed 21 clinical questions (CQs). Methods and Results: A review of these 15 CQs was performed in accordance with the methodology for establishing clinical guidelines. The 15 recommendations for each of these CQs were developed and discussed until consensus by the PGMC was reached. Moreover, outside members who had no involvement in these guidelines evaluated the contents using the Appraisal of Guidelines for Research and Evaluation (AGREE) II reporting checklist. Conclusion: These guidelines have been produced for the adequate management of lymphedema by doctors and other medical staff on the lymphedema management team of medical institutes, including nurses, physical technicians, and occupational therapists.


Assuntos
Neoplasias da Mama , Linfedema , Humanos , Feminino , Japão , Linfedema/diagnóstico , Linfedema/etiologia , Linfedema/terapia , Prática Clínica Baseada em Evidências
5.
J Dermatol ; 49(12): 1268-1277, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36093796

RESUMO

Sensitization to galactose-α-1,3-galactose (α-Gal) leads to the development of α-Gal syndrome, which includes red meat allergy and cetuximab-induced anaphylaxis. Since tick bites represent the main cause of α-Gal sensitization, it was speculated that sensitization to α-Gal occurs throughout Japan. However, few cohort studies have investigated α-Gal sensitization in Japan. Therefore, we aimed to elucidate the subclinical sensitization rate to α-Gal in Japan. Sera were obtained from 300 participants without food or cetuximab allergy at Shimane University Hospital (Shimane prefecture), Tokyo Medical and Dental University Hospital (Tokyo metropolis), and Tohoku University Hospital (Miyagi prefecture). ImmunoCAP-bovine thyroglobulin (BTG), ImmunoCAP-beef, and IgE immunoblotting with cetuximab were performed to detect α-Gal-specific IgE. Clinical information was collected from participants using a questionnaire. The overall positivity rate of ImmunoCAP-BTG was 4.0% without significant inter-institute differences, whereas that for ImmunoCAP-beef was 9.7% with a significant inter-institute difference. Tokyo Medical and Dental University Hospital (19.0%) had the highest positivity rate. The positivity rate based on cetuximab IgE immunoblotting was 2.7%, without any significant inter-institute differences. The overall positivity rate for both ImmunoCAP-BTG and cetuximab immunoblotting was 2.0%, with a significant inter-institute difference; 5.0% of Shimane University Hospital was the highest. Two cases showed sensitization against the non-α-Gal epitope of cetuximab. The overall positivity rate for both ImmunoCAP-beef and cetuximab immunoblotting was 1.3%, without significant inter-institute differences. Male sex was associated with positive beef-specific IgE. The prevalence of subclinical sensitization to α-Gal is estimated at 2.0%-4.0% in Japan and may be higher in rural areas, supporting an association between tick bites and α-Gal sensitization. In contrast, the prevalence of subclinical sensitization to beef is 9.7% in Japan and is highest in Tokyo Metropolis, suggesting the presence of another IgE-binding epitope apart from α-Gal and another sensitization route in the sensitization to beef IgE.


Assuntos
Hipersensibilidade Alimentar , Picadas de Carrapatos , Masculino , Bovinos , Animais , Humanos , Galactose , Prevalência , Cetuximab/efeitos adversos , Estudos de Coortes , Japão/epidemiologia , Hipersensibilidade Alimentar/epidemiologia , Hipersensibilidade Alimentar/diagnóstico , Imunoglobulina E , Alérgenos , Epitopos
6.
Asian J Endosc Surg ; 15(2): 415-426, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34954907

RESUMO

In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and efficacy of endoscopic surgery have been evaluated. In accordance with the social acceptance of endoscopic surgery as a less invasive type of surgery, the number of endoscopic procedures performed has increased in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has played an important role in the development of endoscopic surgery in Japan. Notably, a technical skills certification system for surgeons was established by the JSES to train instructors on how to teach safe endoscopic surgery. Furthermore, the JSES has conducted a national survey every 2 years. In 2019, 291,792 patients underwent endoscopic surgery in all surgical domains, such as abdominal, thoracic, mammary and thyroid gland, cardiovascular, obstetrics and gynecology, urologic, orthopedic, and plastic surgery. The 15th National Survey of Endoscopic Surgery conducted by the JSES demonstrated the status of laparoscopic surgery in Japan in 2018-2019.


Assuntos
Colecistectomia Laparoscópica , Laparoscopia , Cirurgiões , Humanos , Japão , Laparoscopia/métodos
7.
Eur J Surg Oncol ; 46(7): 1334-1338, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32146054

RESUMO

INTRODUCTION: Late-onset lower limb lymphedema (LLL) is a significant clinical challenge for physicians dealing with patients that undergo treatment involving the pelvic cavity. We aimed to clarify the prevalence of and risk factors for late-onset LLL after treatment for gynecological cancer. METHODS: We conducted a multicenter retrospective study using records of cases in which LLL diagnosed by physical findings and measurement of limbs girths. Patients with LLL after treatment for uterine cervical, endometrial, and ovarian cancer were sequentially enrolled. We examined the timing of LLL onset and the associations between the time to onset and clinical characteristics, including age, type of cancer, lymphadenectomy sites, and performance of radiotherapy. We also investigated the risk factors for late-onset LLL and their effects on the cumulative incidence of late-onset LLL. RESULTS: In total, 711 patients fulfilled the required criteria. Mean age of was 50.2 years old and median follow-up period was 5.05 years. More than half of them (50.5%) presented with LLL ≥5 years after undergoing treatment for gynecological cancer. A substantial number of patients (29.4%) developed LLL ≥10 years after undergoing treatment for gynecological cancer. Being aged <50 years [(odds ratio (OR): 1.919, P = 0.001), cervical cancer (OR: 1.912, P = 0.001), and radiotherapy (OR: 1.664, P = 0.017) were identified as significant risk factors for late-onset LLL in multivariate logistic regression analysis. CONCLUSIONS: A substantial number of patients present with LLL ≥5 years after receiving treatment for gynecological malignancies. Clinicians are required to identify high-risk patients and inform them of the risk of late-onset LLL.


Assuntos
Neoplasias do Endométrio/terapia , Linfedema/epidemiologia , Neoplasias Ovarianas/terapia , Neoplasias do Colo do Útero/terapia , Adulto , Fatores Etários , Idoso , Feminino , Seguimentos , Humanos , Incidência , Extremidade Inferior , Pessoa de Meia-Idade , Radioterapia , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo
8.
Asian J Endosc Surg ; 13(1): 7-18, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31828925

RESUMO

In Japan, the first endoscopic surgery, a laparoscopic cholecystectomy, was performed in 1990. Since then, operative procedures have been standardized, and the safety and efficacy of endoscopic surgery have been evaluated. In accordance with the social acceptance of endoscopic surgery as a less invasive type of surgery, the number of endoscopic procedures performed has increased in all surgical domains. The Japan Society for Endoscopic Surgery (JSES) has played an important role in the development of endoscopic surgery in Japan. Notably, a technical skills certification system for surgeons was established by the JSES to train instructors on how to teach safe endoscopic surgery. Furthermore, the JSES has conducted a national survey every two years to evaluate the status of endoscopic surgery over time. In 2017, 248 743 patients underwent endoscopic surgery in all surgical domains, such as abdominal, thoracic, mammary and thyroid gland, cardiovascular, obstetrics and gynecology, urologic, orthopedic, and plastic surgery. The 14th National Survey of Endoscopic Surgery conducted by the JSES demonstrated the status of laparoscopic surgery in Japan in 2016-2017.


Assuntos
Endoscopia/métodos , Endoscopia/estatística & dados numéricos , Endoscopia/efeitos adversos , Endoscopia/educação , Pesquisas sobre Atenção à Saúde/estatística & dados numéricos , Humanos , Japão/epidemiologia , Sociedades Médicas/estatística & dados numéricos
9.
Gan To Kagaku Ryoho ; 36(2): 241-5, 2009 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-19223738

RESUMO

General treatments for breast cancer patients, such as surgery, chemotherapy, radiotherapy and lymphatic edema drainage, are performed at the Department of Breast Surgery in Kyushu Central Hospital. In those treatments, pharmacists provide the pharmaceutical treatment. Combination chemotherapy of doxorubicin and cyclophosphamide (AC therapy) is one of the standard regimens for breast cancer. In breast cancer patients who received AC therapy, we carried out investigations on side effects, and prepared pamphlets to support patients' self-management in their daily lives. In the process of preparing pamphlets, we made check sheets to monitor the severity and incidence of side effects. Based on the results of analysis and patients' opinions as well as staff remarks, we prepared pamphlets. According to the evaluation survey, pamphlets are regarded as useful. To meet the needs of patients, we intend to periodically revise pamphlets by continuing investigations on side effects, and provide up-to-date information.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias da Mama/tratamento farmacológico , Ciclofosfamida/efeitos adversos , Ciclofosfamida/uso terapêutico , Doxorrubicina/efeitos adversos , Doxorrubicina/uso terapêutico , Folhetos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
10.
Cancer Chemother Pharmacol ; 61(3): 509-14, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17516068

RESUMO

PURPOSE: To determine the response rate and toxicity profile of trastuzumab and capecitabine in women with HER2-overexpressing advanced breast cancer. PATIENTS AND METHODS: A total of 59 patients from 6 participating centers in Japan entered onto the study of trastuzumab and capecitabine. Eighty six percent of women had received prior chemotherapy as part of adjuvant (21.4%) or metastatic treatment (48.2%), or both (16.1%), including substantial portions of patients who had previously received either CMF (7.1%), anthracyclines (28.6%), taxanes (25.0%), or both types (25.0%) of chemotherapy. RESULTS: Responses were observed in 28 of 56 patients (overall response rate, 50%). The response rate was 65.0% in patients treated with trastuzumab and capecitabine as first-line therapy for metastatic disease, and 62.5% among HER2 +3 positive patients, while high response rates were also seen in women treated with second- or third-line therapy. Patients receiving trastuzumab and capecitabine as first-line therapy had a longer TTP than did patients receiving this treatment as second- or third-line therapy (median TTP, 280 vs. 130 days, P < 0.05). Further, patients receiving trastuzumab and capecitabine as first-line therapy had longer OS than did patients receiving this treatment as second- or third-line therapy (median OS, 780 days vs. 480 weeks, P < 0.05). The treatment-related adverse events were hand-foot syndrome (30.4%), nausea (25%), diarrhea (10.7%), stomatitis (10.7%), fatigue (7.1%), and vomiting (5.4%). However, the majority were Grade 1-2 adverse events and only six patients experienced Grade 3 adverse events. Further Grade 1 cardiac toxicity was observed in one patient, while there were no cases of alopecia and treatment-related death. CONCLUSION: Trastuzumab in combination with capecitabine is highly active in women with HER2-overexpressing metastatic breast cancer and is well tolerated.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/genética , Genes erbB-2/genética , Administração Oral , Adulto , Idoso , Alopecia/induzido quimicamente , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais Humanizados , Antimetabólitos Antineoplásicos/administração & dosagem , Antineoplásicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Neoplasias Ósseas/secundário , Neoplasias da Mama/patologia , Capecitabina , Desoxicitidina/administração & dosagem , Desoxicitidina/análogos & derivados , Feminino , Fluoruracila/administração & dosagem , Fluoruracila/análogos & derivados , Cardiopatias/induzido quimicamente , Humanos , Infusões Intravenosas , Japão , Pessoa de Meia-Idade , Trastuzumab , Resultado do Tratamento
11.
Oncol Rep ; 19(4): 981-5, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18357385

RESUMO

Primary small cell carcinoma of the breast is a rare tumor of which less than 40 cases have been reported in the literature. Because of its rarity, its biological and clinical characteristics are still not fully understood and, to date, no standard therapy has been developed. Here, we present a case and a review of the literature regarding this cancer, focusing on clinicopathological findings and treatment. Primary small cell carcinoma of the breast differs from more common types of breast cancer in its biological features. It is anticipated that an improved understanding of the clinical characteristics of this tumor will result in the development of new therapeutic modalities, which would improve its prognosis.


Assuntos
Neoplasias da Mama/patologia , Carcinoma de Células Pequenas/patologia , Adulto , Neoplasias da Mama/terapia , Carcinoma de Células Pequenas/terapia , Feminino , Humanos
12.
Surgery ; 131(1 Suppl): S35-8, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11821785

RESUMO

BACKGROUND: In order to acquire an improved prognosis, preoperative hyperthermia combined with chemotherapy and radiotherapy (HCR) has been performed in our department for patients with esophageal carcinoma. METHODS: The experimental and clinical investigations that have been continuously performed in our department were introduced with regard to the therapeutic effect brought by HCR for carcinoma, chiefly for esophageal carcinoma. RESULTS: A series of our investigations have demonstrated the excellent anticancer effect of HCR for esophageal carcinoma. CONCLUSIONS: Preoperative HCR has contributed to improvements in the prognosis of patients with esophageal carcinoma and is expected to make marked progress in the future with further development of anticancer agents and improvements in the hyperthermia devices.


Assuntos
Neoplasias Esofágicas , Hipertermia Induzida , Antineoplásicos/uso terapêutico , Terapia Combinada , Neoplasias Esofágicas/mortalidade , Neoplasias Esofágicas/cirurgia , Neoplasias Esofágicas/terapia , Humanos , Cuidados Pré-Operatórios , Radioterapia , Ensaios Clínicos Controlados Aleatórios como Assunto , Taxa de Sobrevida
13.
Surgery ; 131(1 Suppl): S211-6, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11821813

RESUMO

BACKGROUND: The axillary lymph node (ALN) status is still the most important prognostic factor in the staging and treatment of breast cancer. Intraoperative lymphatic mapping and sentinel lymphadenectomy techniques were investigated in patients with early-stage breast cancer who did not have clinically palpable ALNs. METHODS: Forty-four patients with breast cancer underwent a sentinel lymph node biopsy (SLNB), followed by a complete axillary lymphadenectomy. Sentinel lymph nodes (SLNs) were detected by means of so-called 2-way mapping with coloring matter and an isotope. Our standard protocol for evaluating metastasis in SLNs included a frozen section at 1 level for reverse transcription polymerase chain reaction (RT-PCR), plus a paraffin section at 1 level for immunohistochemistry (IHC) of cytokeratin 19, while the rest were evaluated by hematoxylin-eosin (H&E) staining. RESULTS: SLNs were identified in 42 (95%) of 44 patients. Twenty-one patients had no metastasis in SLNs; however, ALN metastasis was found in 3 patients. Of these 3 patients, 2 had micrometastasis detected by means of either IHC or RT-PCR. Therefore the false-negative rate was decreased from 7% (3/44) to 2% (1/44). Furthermore, of the remaining 18 ALN-negative patients, micrometastasis was detected by means of either IHC or RT-PCR in 7 (39%) patients. CONCLUSION: We suggest that SLNB is recommended to detect micrometastasis by means of H&E staining, IHC, and RT-PCR. Omitting ALN dissection referred by SLNB should be avoided if SLNs were evaluated only by H&E staining, and/or IHC without RT-PCR.


Assuntos
Neoplasias da Mama/secundário , Queratinas/genética , Biópsia de Linfonodo Sentinela , Adulto , Idoso , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Excisão de Linfonodo , Linfonodos/patologia , Metástase Linfática , Pessoa de Meia-Idade , RNA Mensageiro/análise , Reação em Cadeia da Polimerase Via Transcriptase Reversa
14.
Surgery ; 131(1 Suppl): S217-21, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11821814

RESUMO

BACKGROUND: Clinically, human epidermal growth factor receptor 2 (HER2) overexpression is associated with a faster rate of tumor growth and an increased rate of metastasis, and a patient who is HER2 strongly positive tends to have a poor prognosis and a decreased disease-free survival and overall survival (OS) time. METHODS: We analyzed data on 526 Japanese adult women with breast cancer with respect to the relationship between the status of HER2/neu receptor expression and the recurrent state and survival from detection of the first recurrence. All these women were treated from 1982 to 2000 in the Department of Surgery, National Beppu Hospital, Kyushu, Japan. In 95 patients with metastatic breast cancer after curative resection, the expression of HER2/neu status was examined by using immunohistochemical staining methods (HercepTest). Scores of 0, 1+, 2+, and 3+ were given according to the HercepTest data. Only scores of 2+ and 3+ were assessed as an overexpression of HER2/neu protein and HER2-positive patients. Between the HER2-positive and HER2-negative patients, the survival after surgical intervention, the disease-free survival time, and the survival time after the initial recurrence were compared. RESULTS: An overexpression of HER2/neu receptor protein occurred at a rate of 23.7% (23/97) in the 97 women with metastatic breast cancer. There was no difference in age, tumor size, TN staging system, and the number of lymph node metastases between HER2-positive and HER2-negative patients. Almost all HER2-positive patients had a negative estrogen receptor status (14/15 [93.3%]). The initial sites of recurrence were classified as (1) soft tissue, bone, and viscera or (2) soft tissue, bone, lung-pleura, liver, and brain. For the HER2-positive patient, viscera, especially the liver and lung, were predominant initial sites of recurrence. Survival rates, OS, disease-free survival time, and time after first recurrence were all analyzed. Although there was no difference in disease-free survival time, there were significant differences between the HER2-positive and HER2-negative groups in OS and the time after initial recurrence. CONCLUSIONS: Metastatic breast cancer with overexpression of HER2/neu tends toward a poor prognosis, especially after the first recurrence. For such patients with metastatic breast cancer, a high-dose anthracycline-containing regimen might be needed.


Assuntos
Neoplasias da Mama/mortalidade , Neoplasias da Mama/secundário , Receptor ErbB-2/análise , Adulto , Idoso , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Receptor ErbB-2/genética , Taxa de Sobrevida
15.
Surgery ; 131(1 Suppl): S222-5, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11821815

RESUMO

BACKGROUND: Recently, PEA3 has been reported to suppress HER-2/neu overexpression by promoter activity and thereby inhibit tumorigenesis of breast cancer both in vitro and in vivo. METHODS: The expression of PEA3 and the clinicopathologic features of 89 patients with breast cancer were investigated. The expression of PEA3 was immunohistochemically detected in 42 (47.2%) of 89 patients. RESULTS: The correlation between the expression of PEA3 and the clinicopathologic features were nil with regard to lymph node metastasis, hormone receptor, blood vessel invasion, and lymphatic vessel invasion. The disease-free survival rate was shorter for the PEA3-negative groups than for the PEA3-positive ones, but with no statistically significant difference. The overall survival rate after surgical resection in patients who were PEA3-positive vs PEA3-negative was 100% vs 87.2%, respectively, at 3 years and 89.8% vs 72.7%, respectively, at 6 years (P =.0472). CONCLUSIONS: The expression of PEA3 in breast cancer might therefore be a novel prognostic factor.


Assuntos
Neoplasias da Mama/patologia , Fatores de Transcrição/análise , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Mama/química , Neoplasias da Mama/mortalidade , Intervalo Livre de Doença , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Taxa de Sobrevida
16.
Surgery ; 131(1 Suppl): S324-9, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11821832

RESUMO

BACKGROUND: Subcutaneous mastectomy and reconstruction (SMR) is well established; however, most incisions are made directly on the breast, and the majority of patients care about visible scars even if they are satisfied with the reconstructed breast. METHODS: From August 1998 to March 2001, a total of 46 patients (including 2 bilateral cases) with breast cancer underwent SMR using a saline-filled prosthesis by lateral axillary incision. There were 25 patients who received previous SMR without endoscopic assistance (group A) and 21 patients who underwent an endoscope-assisted SMR (E-SMR) (group B). These 2 groups were compared for curability, morbidity, and cosmesis. RESULTS: The median follow-up period was 19.2 + 9.8 months (range, 5.8 - 35.2 months). No significant difference was found in clinicopathologic data between the 2 groups. The operation time was 176 minutes in group A and 237 minutes in group B, and the estimated blood loss was 189 mL vs 356 mL, respectively. No critical complications were seen in either group. The average length of incision was 10 cm in group A and 5.7 cm in group B. As for the patients' satisfaction, the incidence of "excellent" plus "good" ratings was 76% in group A and 90.4% in group B. CONCLUSIONS: E-SMR is a new option that can provide an improved operative view and better cosmetic results for the treatment of breast cancer than with SMR. The operation time is longer than for SMR, but the incision is drastically shorter, resulting in better cosmesis and increased patient satisfaction.


Assuntos
Neoplasias da Mama/cirurgia , Mamoplastia/métodos , Mastectomia/métodos , Adulto , Neoplasias da Mama/mortalidade , Endoscopia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Satisfação do Paciente
17.
Hepatogastroenterology ; 51(60): 1713-6, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15532811

RESUMO

BACKGROUND/AIMS: The multiple occurrence of primary squamous cell carcinoma of the esophagus is often observed, and most such occurrences are double cancers. There have also been some cases with three or more intra-esophageal cancers, however, no detailed clinicopathologic study has yet been performed in the literature. METHODOLOGY: Two hundred and fifty patients of primary esophageal squamous cell carcinoma without preoperative treatment that underwent esophageal resection were re-evaluated by serial histopathologic investigations and we analyzed the data of ten patients with three or more intraesophageal cancers. RESULTS: The clinical and histopathologic characteristics were as follows; 1) all but one of the cases were male, 2) all patients had a history of both heavy smoking and drinking but only one case had a family history of esophageal cancers among their siblings, 3) the depth of invasion in the carcinomas was restricted to within the submucosal layer of the esophageal wall, which was defined as superficial esophageal carcinoma, almost all (90%) of the cases accompanied esophageal squamous epithelial dysplasia. CONCLUSIONS: Based on these prominent characteristics of considerable multiple intra-esophageal cancers, a new clinical entity of "esophageal field cancers" could thus be suggested.


Assuntos
Carcinoma de Células Escamosas/epidemiologia , Neoplasias Esofágicas/epidemiologia , Neoplasias Esofágicas/patologia , Invasividade Neoplásica/patologia , Adulto , Idoso , Consumo de Bebidas Alcoólicas/efeitos adversos , Biópsia por Agulha , Estudos de Coortes , Neoplasias Esofágicas/cirurgia , Esofagectomia/métodos , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Distribuição por Sexo , Fumar/efeitos adversos , Análise de Sobrevida , Resultado do Tratamento
18.
Hepatogastroenterology ; 49(48): 1560-2, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12397735

RESUMO

BACKGROUND/AIMS: It is known to be difficult to determine thermal dosage in clinical tumor treatment. The aim of this study is to examine whether the quantitative heating dose reflects the treatment effect in esophageal cancer. METHODOLOGY: Hyperthermo-chemoradiotherapy was performed on 14 patients with advanced esophageal cancer. The heating dosage was calculated as an integration of the isoeffective dose at 43 degrees C using the following formulas: delta teq(T) = 2(T-43).delta t (second)--(a) (> or = 42.5 degrees C) delta teq(T) = 2(42.5-43).6(T-42.5).delta t (second)--(b) (< 42.5 degrees C) When hyperthermia continued at the same temperature for 2 seconds or more, the temperature was regarded as the heating temperature, and the cumulative time was defined as the thermal dose which was administered during the heating period. RESULTS: Nine patients were resectable and the remaining 5 patients were categorized as non-resectable. The treatment effect was evaluated by an esophagram and an endoscopic examination both pre- and post-hyperthermo-chemoradiotherapy. Five patients were regarded to demonstrate a complete response, while 2 showed a partial response and 8 demonstrated no change, respectively. The maximal cumulative heating time was 2,312 seconds in the complete response group, 1,811 seconds in the partial response group and 1,260 seconds in the no change group (p = 0.038). The minimal and average cumulative heating time did not show any correlation with the treatment effect. CONCLUSIONS: Our results indicate that the thermal doses calculated by those formulas were adequate for clinical hyperthermia in esophageal cancer patients.


Assuntos
Neoplasias Esofágicas/terapia , Hipertermia Induzida/métodos , Antineoplásicos/administração & dosagem , Distribuição de Qui-Quadrado , Cisplatino/administração & dosagem , Terapia Combinada , Neoplasias Esofágicas/diagnóstico por imagem , Neoplasias Esofágicas/tratamento farmacológico , Humanos , Radiografia , Dosagem Radioterapêutica , Resultado do Tratamento
19.
Work ; 41 Suppl 1: 5759-61, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22317678

RESUMO

The purpose of this study was to clarify the relationship between collective efficacy and contextual performance among university athletes in Japan. We carried out 305 university athletes (201 males, 104 females) from 14 teams in various geographic areas in Japan. The average age of the participants was 19.91 years (SD = 1.01). The kinds of sports were soccer, basketball, baseball, volleyball, and so on. Then, using Collective Efficacy Questionnaire for Sports (CEQS; Sandra E. Short et al., 2005) and Contextual Performance Scale (Ikeda, and Furukawa, 2008), we examined the relationship between collective efficacy and Contextual performance. In conclusion, this study provided the following three remarks. 1) There are relationship between collective efficacy and contextual performance. 2) Contextual performance execution level improve collective efficacy. 3) It is important to always recommend contextual performance in own team to strengthen the collective efficacy more.


Assuntos
Desempenho Atlético , Comportamento Cooperativo , Eficiência , Esportes/psicologia , Adulto , Feminino , Humanos , Japão , Masculino , Inquéritos e Questionários , Adulto Jovem
20.
Work ; 41 Suppl 1: 5762-3, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22317679

RESUMO

The purpose of this study was to examine the effect in the experience of TB among university baseball team from the view point of team-vitalization. We carry out one university baseball team (102 males, 6 female). The average age of the participants was 19.99 years (SD = 1.41). Then, using Check List of Team- Vitalization that was developed by consulting firm in Japan, we examined the degrees of team-vitalization. The answers of this investigation were collected from the participants at fifth times (before intervention of TB, immediately after TB, after three months of TB, before intervention of follow-up training of TB, and immediately after follow-up training of TB). This study for eight months provided the following three conclusions; 1) University baseball team was vitalized through the experience of TB. 2) Team-vitalization was higher than before TB experience, but this effect of the TB did not seem to be permanent. 3) To keep intervention of TB was very important.


Assuntos
Beisebol/psicologia , Comportamento Cooperativo , Impulso (Psicologia) , Adulto , Eficiência , Feminino , Humanos , Relações Interpessoais , Japão , Estudos Longitudinais , Masculino , Objetivos Organizacionais , Adulto Jovem
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