Detalhe da pesquisa
1.
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.
Cell
; 136(6): 1017-31, 2009 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19303846
2.
Addressing Transcriptional Dysregulation in Cancer through CDK9 Inhibition.
Biochemistry
; 62(6): 1114-1123, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36854448
3.
A Versatile Isocyanate-Mediated Strategy for Appending Chemical Tags onto Drug-Like Small Molecules.
Bioconjug Chem
; 34(12): 2181-2186, 2023 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38052453
4.
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Nat Chem Biol
; 12(2): 102-8, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656089
5.
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.
Proc Natl Acad Sci U S A
; 108(17): 6817-22, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21482810
6.
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma.
Nat Commun
; 15(1): 963, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38302473
7.
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.
Proc Natl Acad Sci U S A
; 107(44): 18787-92, 2010 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20956335
8.
Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors.
bioRxiv
; 2023 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066194
9.
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance.
J Virol
; 85(6): 2859-68, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21209116
10.
Unbiased binding assays for discovering small-molecule probes and drugs.
Bioorg Med Chem
; 20(6): 1979-89, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22230199
11.
Identifying the proteins to which small-molecule probes and drugs bind in cells.
Proc Natl Acad Sci U S A
; 106(12): 4617-22, 2009 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19255428
12.
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery.
Science
; 377(6604): eabm5551, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862544
13.
Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer.
Cell Rep Methods
; 2(8): 100273, 2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35942328
14.
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells.
Cell Rep
; 39(4): 110752, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35476984
15.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Nat Chem Biol
; 5(3): 154-6, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19151731
16.
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.
Bioorg Med Chem Lett
; 21(14): 4164-9, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21696956
17.
Advances in targeting 'undruggable' transcription factors with small molecules.
Nat Rev Drug Discov
; 20(9): 669-688, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34006959
18.
Nailing Down a Notoriously Elusive Cancer Target: Direct Inhibition of MYC by a Covalent Small Molecule.
Cell Chem Biol
; 28(1): 1-3, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482085
19.
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
Cell Chem Biol
; 28(2): 134-147.e14, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33086052
20.
Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aß peptide and reduce its cytotoxicity.
J Am Chem Soc
; 132(47): 17015-22, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062056