Pesquisa | BVS Violência e Saúde

1.

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.

Chakraborty, Anutosh; Koldobskiy, Michael A; Bello, Nicholas T; Maxwell, Micah; Potter, James J; Juluri, Krishna R; Maag, David; Kim, Seyun; Huang, Alex S; Dailey, Megan J; Saleh, Masoumeh; Snowman, Adele M; Moran, Timothy H; Mezey, Esteban; Snyder, Solomon H.

Cell ; 143(6): 897-910, 2010 Dec 10.

Artigo em Inglês | MEDLINE | ID: mdl-21145457

2.

DNA methylation entropy is associated with DNA sequence features and developmental epigenetic divergence.

Fang, Yuqi; Ji, Zhicheng; Zhou, Weiqiang; Abante, Jordi; Koldobskiy, Michael A; Ji, Hongkai; Feinberg, Andrew P.

Nucleic Acids Res ; 51(5): 2046-2065, 2023 03 21.

Artigo em Inglês | MEDLINE | ID: mdl-36762477

3.

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2.

Rao, Feng; Cha, Jiyoung; Xu, Jing; Xu, Risheng; Vandiver, M Scott; Tyagi, Richa; Tokhunts, Robert; Koldobskiy, Michael A; Fu, Chenglai; Barrow, Roxanne; Wu, Mingxuan; Fiedler, Dorothea; Barrow, James C; Snyder, Solomon H.

Mol Cell ; 79(4): 702, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32822581

4.

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.

Feinberg, Andrew P; Koldobskiy, Michael A; Göndör, Anita.

Nat Rev Genet ; 17(5): 284-99, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-26972587

5.

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.

Rao, Feng; Cha, Jiyoung; Xu, Jing; Xu, Risheng; Vandiver, M Scott; Tyagi, Richa; Tokhunts, Robert; Koldobskiy, Michael A; Fu, Chenglai; Barrow, Roxanne; Wu, Mingxuan; Fiedler, Dorothea; Barrow, James C; Snyder, Solomon H.

Mol Cell ; 54(1): 119-132, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24657168

6.

Ranking genomic features using an information-theoretic measure of epigenetic discordance.

Jenkinson, Garrett; Abante, Jordi; Koldobskiy, Michael A; Feinberg, Andrew P; Goutsias, John.

BMC Bioinformatics ; 20(1): 175, 2019 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-30961526

7.

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.

Chakraborty, Anutosh; Werner, J Kent; Koldobskiy, Michael A; Mustafa, Asif K; Juluri, Krishna R; Pietropaoli, Joseph; Snowman, Adele M; Snyder, Solomon H.

Proc Natl Acad Sci U S A ; 108(6): 2205-9, 2011 Feb 08.

Artigo em Inglês | MEDLINE | ID: mdl-21262846

8.

DNA methylation landscapes in DIPG reveal methylome variability that can be modified pharmacologically.

Tetens, Ashley R; Martin, Allison M; Arnold, Antje; Novak, Orlandi V; Idrizi, Adrian; Tryggvadottir, Rakel; Craig-Schwartz, Jordyn; Liapodimitri, Athanasia; Lunsford, Kayleigh; Barbato, Michael I; Eberhart, Charles G; Resnick, Adam C; Raabe, Eric H; Koldobskiy, Michael A.

Neurooncol Adv ; 6(1): vdae023, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38468866

9.

A road map for the treatment of pediatric diffuse midline glioma.

Koschmann, Carl; Al-Holou, Wajd N; Alonso, Marta M; Anastas, Jamie; Bandopadhayay, Pratiti; Barron, Tara; Becher, Oren; Cartaxo, Rodrigo; Castro, Maria G; Chung, Chan; Clausen, Madison; Dang, Derek; Doherty, Robert; Duchatel, Ryan; Dun, Matthew; Filbin, Mariella; Franson, Andrea; Galban, Stefanie; Garcia Moure, Marc; Garton, Hugh; Gowda, Pruthvi; Marques, Joana Graca; Hawkins, Cynthia; Heath, Allison; Hulleman, Esther; Ji, Sunjong; Jones, Chris; Kilburn, Lindsay; Kline, Cassie; Koldobskiy, Michael A; Lim, Daniel; Lowenstein, Pedro R; Lu, Q Richard; Lum, Joanna; Mack, Stephen; Magge, Suresh; Marini, Bernard; Martin, Donna; Marupudi, Neena; Messinger, Dana; Mody, Rajen; Morgan, Meredith; Mota, Mateus; Muraszko, Karin; Mueller, Sabine; Natarajan, Siva Kumar; Nazarian, Javad; Niculcea, Michael; Nuechterlein, Nicholas; Okada, Hideho.

Cancer Cell ; 42(1): 1-5, 2024 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-38039965

10.

p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.

Koldobskiy, Michael A; Chakraborty, Anutosh; Werner, J Kent; Snowman, Adele M; Juluri, Krishna R; Vandiver, M Scott; Kim, Seyun; Heletz, Shira; Snyder, Solomon H.

Proc Natl Acad Sci U S A ; 107(49): 20947-51, 2010 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-21078964

11.

Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation.

Ktena, Yiouli P; Koldobskiy, Michael A; Barbato, Michael I; Fu, Han-Hsuan; Luznik, Leo; Llosa, Nicolas J; Haile, Azeb; Klein, Orly R; Liu, Chen; Gamper, Christopher J; Cooke, Kenneth R.

J Clin Invest ; 132(13)2022 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-35608905

12.

HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

Chakraborty, Anutosh; Koldobskiy, Michael A; Sixt, Katherine M; Juluri, Krishna R; Mustafa, Asif K; Snowman, Adele M; van Rossum, Damian B; Patterson, Randen L; Snyder, Solomon H.

Proc Natl Acad Sci U S A ; 105(4): 1134-9, 2008 Jan 29.

Artigo em Inglês | MEDLINE | ID: mdl-18195352

13.

Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities.

Christodoulou, Ilias; Ho, Won Jin; Marple, Andrew; Ravich, Jonas W; Tam, Ada; Rahnama, Ruyan; Fearnow, Adam; Rietberg, Cambrynne; Yanik, Sean; Solomou, Elena E; Varadhan, Ravi; Koldobskiy, Michael A; Bonifant, Challice L.

J Immunother Cancer ; 9(12)2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34896980

14.

Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis.

Koldobskiy, Michael A; Jenkinson, Garrett; Abante, Jordi; Rodriguez DiBlasi, Varenka A; Zhou, Weiqiang; Pujadas, Elisabet; Idrizi, Adrian; Tryggvadottir, Rakel; Callahan, Colin; Bonifant, Challice L; Rabin, Karen R; Brown, Patrick A; Ji, Hongkai; Goutsias, John; Feinberg, Andrew P.

Nat Biomed Eng ; 5(4): 360-376, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33859388

15.

A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML.

Koldobskiy, Michael A; Abante, Jordi; Jenkinson, Garrett; Pujadas, Elisabet; Tetens, Ashley; Zhao, Feifei; Tryggvadottir, Rakel; Idrizi, Adrian; Reinisch, Andreas; Majeti, Ravindra; Goutsias, John; Feinberg, Andrew P.

Epigenetics ; 15(8): 841-858, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32114880

16.

Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina.

Park, Tea Soon; Zimmerlin, Ludovic; Evans-Moses, Rebecca; Thomas, Justin; Huo, Jeffrey S; Kanherkar, Riya; He, Alice; Ruzgar, Nensi; Grebe, Rhonda; Bhutto, Imran; Barbato, Michael; Koldobskiy, Michael A; Lutty, Gerard; Zambidis, Elias T.

Nat Commun ; 11(1): 1195, 2020 03 05.

Artigo em Inglês | MEDLINE | ID: mdl-32139672

17.

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.

Kim, Seyun; Kim, Sangwon F; Maag, David; Maxwell, Micah J; Resnick, Adam C; Juluri, Krishna R; Chakraborty, Anutosh; Koldobskiy, Michael A; Cha, Seung Hun; Barrow, Roxanne; Snowman, Adele M; Snyder, Solomon H.

Cell Metab ; 13(2): 215-21, 2011 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-21284988

18.

Inositol pyrophosphates in cell death and life.

Koldobskiy, Michael A; Snyder, Solomon H.

Cell Cycle ; 10(4): 568-70, 2011 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-21293185

19.

Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity.

Yang, Zhi-Qiang; Kwok, Benjamin H B; Lin, Songnian; Koldobskiy, Michael A; Crews, Craig M; Danishefsky, Samuel J.

Chembiochem ; 4(6): 508-13, 2003 Jun 06.

Artigo em Inglês | MEDLINE | ID: mdl-12794861

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