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Nat Commun ; 15(1): 2715, 2024 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-38548742

RESUMO

Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans, the evolutionarily conserved large EVs, known as exophers, are part of a maternal somatic tissue resource management system. Consequently, the offspring of individuals exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling the complex inter-tissue and social dynamics that govern exophergenesis. We found that ascr#10, the primary male pheromone, enhances exopher production in hermaphrodites, mediated by the G-protein-coupled receptor STR-173 in ASK sensory neurons. In contrast, pheromone produced by other hermaphrodites, ascr#3, diminishes exophergenesis within the population. This process is regulated via the neuropeptides FLP-8 and FLP-21, which originate from the URX and AQR/PQR/URX neurons, respectively. Our results reveal a regulatory network that controls the production of somatic EV by the nervous system in response to social signals.


Assuntos
Proteínas de Caenorhabditis elegans , Vesículas Extracelulares , Humanos , Animais , Masculino , Caenorhabditis elegans/genética , Feromônios , Proteínas de Caenorhabditis elegans/genética , Neurônios/fisiologia
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