Detalhe da pesquisa
1.
Discovery of a new binding mode for a series of liver X receptor agonists.
Bioorg Med Chem Lett
; 22(7): 2407-10, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406115
2.
Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg Med Chem Lett
; 22(19): 6212-7, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22929232
3.
Discovery and optimization of a series of liver X receptor antagonists.
Bioorg Med Chem Lett
; 22(18): 5966-70, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22901900
4.
Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
J Med Chem
; 63(20): 11602-11614, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32965113
5.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
6.
Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.
J Am Chem Soc
; 131(50): 18139-46, 2009 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19924990
7.
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ACS Med Chem Lett
; 10(9): 1302-1308, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531201
8.
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.
Bioorg Med Chem Lett
; 18(24): 6352-6, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18993068
9.
Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.
J Med Chem
; 55(8): 3837-51, 2012 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22458568
10.
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
J Med Chem
; 55(11): 4936-54, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524527