Detalhe da pesquisa
1.
Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability and facial anomalies syndrome with distinctive genome-wide DNA hypomethylation.
Hum Mol Genet
; 32(9): 1439-1456, 2023 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36458887
2.
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Bioorg Med Chem
; 52: 116500, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34801826
3.
Structure of PCNA in complex with DNMT1 PIP box reveals the basis for the molecular mechanism of the interaction.
Biochem Biophys Res Commun
; 516(2): 578-583, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235252
4.
The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5.
Elife
; 122023 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36734974
5.
Structural basis for activation of DNMT1.
Nat Commun
; 13(1): 7130, 2022 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36414620
6.
Serine 298 Phosphorylation in Linker 2 of UHRF1 Regulates Ligand-Binding Property of Its Tandem Tudor Domain.
J Mol Biol
; 432(14): 4061-4075, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32428527
7.
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.
Nat Commun
; 11(1): 1222, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144273
8.
Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
Structure
; 27(3): 485-496.e7, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30639225