[International register "Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients (ACTIV SARS-CoV-2)"].

.

[Remodeling of heart and neutrophil intracellular metabolism in obese men].

AIM: To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men. MATERIALS AND METHODS: 85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils. RESULTS AND DISCUSSION: Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium. CONCLUSION: Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.

[Deutonymphs of the genus Hirstionyssus of the fauna of the USSR (Acarina, Hirstionyssidae)]. / Deitonimfy roda Hirstionyssus fauny SSSR (Acarina, Hirstionyssidae)

Described and figured are deutonymphs of 18 species of the genus Hirstionyssus Fonseca, 1948, parasites of small mammals (H. carnifex (L. C. Koch) Oudemans, 1913; H. blanchardi (Trouessart, 1904); H. ellobii Bregetova, 1956; H. myospalacis Zemskaja et Piontkovskaja, 1957; H. transiliensis Bregetova, 1956; H. georgicus Bregetova, 1956; H. sciurinus (Hirst, 1921); H. confucianus (Hirst, 1921); H. bregetovae Razumova, 1953; H. macedonicus (Hirst, 1921); H. pauli Willmann, 1952; H. criceti (Sulzer, 1774); H. latiscutatus (Meillon et Lavoipierre, 1944); H. apodemi Zuevsky, 1970; H. pavlovskii Zemskaja, 1959; H. soricis (Turk, 1945); H. meridianus Zemskaja, 1955; H. isabellinus Oudemans, 1913); Keys to deutonymphs of the genus Hirstionyssus are given for the first time.

[The civil legal procedural competence of schizophrenia patients]. / Grazhdanskaia protsessual'naia deesposobnost' bol'nykh shizofreniei.

Discusses the methodological problems of forensic psychiatric evaluations of mental disorders in the structure of the most incident endogenous psychosis, schizophrenia, under conditions of expert evaluation in a civil process. Presents criteria permitting the differentiation between pathological states.

Synthetic heteroprostanoids of A- and E-types as novel non-comprehensive inhibitors of adenylyl cyclase in rat hepatocytes.

Treatment of rat hepatocyte plasma membranes with five novel synthetic heteroprostanoids of A- and E-types significantly decreased basal activity of adenylyl cyclase. Inhibition of forskolin-stimulated activity of the enzyme was seen as well. The maximal effective concentration for all substances tested was found at approximately 5x10(-6)-1x10(-5) M. The values of half maximal concentration (IC50) for all prostanoids were at the region of 0.7-1.1 microM. Prostanoids belonging to cyclopentenone group A (U-39, U-26) were less active than analogs of 11-deoxy-PGE1 (TA-227, TA-280, and TA-239). The strongest inhibitory effect of adenylyl cyclase activity (more than 3 times) was determined in the presence of prostanoid TA-227 possessing hydrophobic 15-phenyl ring and isoxazol group in omega-chain. The investigation of AC activity in the presence of different concentrations of prostanoids and varying concentrations of Mg x ATP has demonstrated that a non-comprehensive mechanism with particular effect takes place in case of AC inhibition by the heteroprostanoids.