Pesquisa | BVS Violência e Saúde

1.

Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication.

Santos-Rosa, Helena; Millán-Zambrano, Gonzalo; Han, Namshik; Leonardi, Tommaso; Klimontova, Marie; Nasiscionyte, Simona; Pandolfini, Luca; Tzelepis, Kostantinos; Bartke, Till; Kouzarides, Tony.

Mol Cell ; 81(13): 2793-2807.e8, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-33979575

2.

Targeting the m⁶A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication.

Burgess, Hannah M; Depledge, Daniel P; Thompson, Letitia; Srinivas, Kalanghad Puthankalam; Grande, Rebecca C; Vink, Elizabeth I; Abebe, Jonathan S; Blackaby, Wesley P; Hendrick, Alan; Albertella, Mark R; Kouzarides, Tony; Stapleford, Kenneth A; Wilson, Angus C; Mohr, Ian.

Genes Dev ; 35(13-14): 1005-1019, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-34168039

3.

Cancer epigenetics: from mechanism to therapy.

Dawson, Mark A; Kouzarides, Tony.

Cell ; 150(1): 12-27, 2012 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-22770212

4.

Human RNA methyltransferase BCDIN3D regulates microRNA processing.

Xhemalce, Blerta; Robson, Samuel C; Kouzarides, Tony.

Cell ; 151(2): 278-88, 2012 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-23063121

5.

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

Yankova, Eliza; Blackaby, Wesley; Albertella, Mark; Rak, Justyna; De Braekeleer, Etienne; Tsagkogeorga, Georgia; Pilka, Ewa S; Aspris, Demetrios; Leggate, Dan; Hendrick, Alan G; Webster, Natalie A; Andrews, Byron; Fosbeary, Richard; Guest, Patrick; Irigoyen, Nerea; Eleftheriou, Maria; Gozdecka, Malgorzata; Dias, Joao M L; Bannister, Andrew J; Vick, Binje; Jeremias, Irmela; Vassiliou, George S; Rausch, Oliver; Tzelepis, Konstantinos; Kouzarides, Tony.

Nature ; 593(7860): 597-601, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33902106

6.

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.

Pandolfini, Luca; Barbieri, Isaia; Bannister, Andrew J; Hendrick, Alan; Andrews, Byron; Webster, Natalie; Murat, Pierre; Mach, Pia; Brandi, Rossella; Robson, Samuel C; Migliori, Valentina; Alendar, Andrej; d'Onofrio, Mara; Balasubramanian, Shankar; Kouzarides, Tony.

Mol Cell ; 74(6): 1278-1290.e9, 2019 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-31031083

7.

Histone core modifications regulating nucleosome structure and dynamics.

Tessarz, Peter; Kouzarides, Tony.

Nat Rev Mol Cell Biol ; 15(11): 703-8, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25315270

8.

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery.

Millan-Zambrano, Gonzalo; Santos-Rosa, Helena; Puddu, Fabio; Robson, Samuel C; Jackson, Stephen P; Kouzarides, Tony.

Mol Cell ; 72(4): 625-635.e4, 2018 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-30454561

9.

Nucleosome-interacting proteins regulated by DNA and histone methylation.

Bartke, Till; Vermeulen, Michiel; Xhemalce, Blerta; Robson, Samuel C; Mann, Matthias; Kouzarides, Tony.

Cell ; 143(3): 470-84, 2010 Oct 29.

Artigo em Inglês | MEDLINE | ID: mdl-21029866

10.

Promoter-bound METTL3 maintains myeloid leukaemia by m⁶A-dependent translation control.

Barbieri, Isaia; Tzelepis, Konstantinos; Pandolfini, Luca; Shi, Junwei; Millán-Zambrano, Gonzalo; Robson, Samuel C; Aspris, Demetrios; Migliori, Valentina; Bannister, Andrew J; Han, Namshik; De Braekeleer, Etienne; Ponstingl, Hannes; Hendrick, Alan; Vakoc, Christopher R; Vassiliou, George S; Kouzarides, Tony.

Nature ; 552(7683): 126-131, 2017 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-29186125

11.

Further Evidence Supporting N7-Methylation of Guanosine (m⁷G) in Human MicroRNAs.

Kouzarides, Tony; Pandolfini, Luca; Barbieri, Isaia; Bannister, Andrew J; Andrews, Byron.

Mol Cell ; 79(2): 201-202, 2020 07 16.

Artigo em Inglês | MEDLINE | ID: mdl-32679073

12.

Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.

Ruivo, Carolina F; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A; Castaldo, Stephanie A; Campos-Laborie, Francisco; Moutinho-Ribeiro, Pedro; Morão, Barbara; Costa-Pinto, Ana; Silva, Soraia; Osorio, Hugo; Ciordia, Sergio; Costa, Jose Luis; Goodrich, David; Cavadas, Bruno; Pereira, Luisa; Kouzarides, Tony; Macedo, Guilherme; Maio, Rui; Carneiro, Fatima; Cravo, Marília; Kalluri, Raghu; Machado, Jose Carlos; Melo, Sonia A.

Gut ; 2022 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-35012996

13.

The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

Viré, Emmanuelle; Curtis, Christina; Davalos, Veronica; Git, Anna; Robson, Samuel; Villanueva, Alberto; Vidal, August; Barbieri, Isaia; Aparicio, Samuel; Esteller, Manel; Caldas, Carlos; Kouzarides, Tony.

Mol Cell ; 53(5): 806-18, 2014 03 06.

Artigo em Inglês | MEDLINE | ID: mdl-24582497

14.

BET inhibitor resistance emerges from leukaemia stem cells.

Fong, Chun Yew; Gilan, Omer; Lam, Enid Y N; Rubin, Alan F; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; Sinha, Devbarna; Yeh, Paul; Morison, Jessica; Giotopoulos, George; Lugo, Dave; Jeffrey, Philip; Lee, Stanley Chun-Wei; Carpenter, Christopher; Gregory, Richard; Ramsay, Robert G; Lane, Steven W; Abdel-Wahab, Omar; Kouzarides, Tony; Johnstone, Ricky W; Dawson, Sarah-Jane; Huntly, Brian J P; Prinjha, Rab K; Papenfuss, Anthony T; Dawson, Mark A.

Nature ; 525(7570): 538-42, 2015 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-26367796

15.

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin.

Santos-Rosa, Helena; Schneider, Robert; Bernstein, Bradley E; Karabetsou, Nickoletta; Morillon, Antonin; Weise, Christoph; Schreiber, Stuart L; Mellor, Jane; Kouzarides, Tony.

Mol Cell ; 70(5): 983, 2018 06 07.

Artigo em Inglês | MEDLINE | ID: mdl-29883612

16.

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

Amaral, Paulo P; Engström, Pär G; Robson, Samuel C; Nielsen, Michael L; Kouzarides, Tony; Castelo-Branco, Gonçalo.

Exp Cell Res ; 381(1): 129-138, 2019 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-31077711

17.

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

Tessarz, Peter; Santos-Rosa, Helena; Robson, Sam C; Sylvestersen, Kathrine B; Nelson, Christopher J; Nielsen, Michael L; Kouzarides, Tony.

Nature ; 505(7484): 564-8, 2014 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-24352239

18.

Citrullination regulates pluripotency and histone H1 binding to chromatin.

Christophorou, Maria A; Castelo-Branco, Gonçalo; Halley-Stott, Richard P; Oliveira, Clara Slade; Loos, Remco; Radzisheuskaya, Aliaksandra; Mowen, Kerri A; Bertone, Paul; Silva, José C R; Zernicka-Goetz, Magdalena; Nielsen, Michael L; Gurdon, John B; Kouzarides, Tony.

Nature ; 507(7490): 104-8, 2014 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-24463520

19.

A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.

Xhemalce, Blerta; Kouzarides, Tony.

Genes Dev ; 24(7): 647-52, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-20299449

20.

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson, Mark A; Prinjha, Rab K; Dittmann, Antje; Giotopoulos, George; Bantscheff, Marcus; Chan, Wai-In; Robson, Samuel C; Chung, Chun-wa; Hopf, Carsten; Savitski, Mikhail M; Huthmacher, Carola; Gudgin, Emma; Lugo, Dave; Beinke, Soren; Chapman, Trevor D; Roberts, Emma J; Soden, Peter E; Auger, Kurt R; Mirguet, Olivier; Doehner, Konstanze; Delwel, Ruud; Burnett, Alan K; Jeffrey, Phillip; Drewes, Gerard; Lee, Kevin; Huntly, Brian J P; Kouzarides, Tony.

Nature ; 478(7370): 529-33, 2011 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-21964340

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