Detalhe da pesquisa
1.
Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase.
Tetrahedron
; 1562024 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38618612
2.
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases.
Biochem Soc Trans
; 49(4): 1723-1734, 2021 08 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34431504
3.
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Molecules
; 26(5)2021 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33668938
4.
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.
Biochemistry
; 59(37): 3447-3462, 2020 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865982
5.
Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.
Chembiochem
; 21(5): 712-722, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31449350
6.
Corrigendum: Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.
Chembiochem
; 21(18): 2701, 2020 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32931129
7.
High-Throughput Discovery and Characterization of Covalent Inhibitors for Protein Tyrosine Phosphatases.
Methods Mol Biol
; 2743: 301-316, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147223
8.
Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant.
J Mol Biol
; 436(4): 168438, 2024 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38185323
9.
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.
J Med Chem
; 67(6): 4496-4524, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38488146
10.
Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae.
ACS Infect Dis
; 7(7): 1969-1984, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33765392
11.
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus.
J Med Chem
; 63(17): 9540-9562, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787141