Pesquisa | BVS Violência e Saúde

1.

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic ß cells in diet-induced obesity.

Ji, Yewei; Sun, Shengyi; Shrestha, Neha; Darragh, Laurel B; Shirakawa, Jun; Xing, Yuan; He, Yi; Carboneau, Bethany A; Kim, Hana; An, Duo; Ma, Minglin; Oberholzer, Jose; Soleimanpour, Scott A; Gannon, Maureen; Liu, Chengyang; Naji, Ali; Kulkarni, Rohit N; Wang, Yong; Kersten, Sander; Qi, Ling.

Nat Immunol ; 20(6): 677-686, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31110312

2.

Deficiency of the metabolic enzyme SCHAD in pancreatic ß-cells promotes amino acid-sensitive hypoglycemia.

St-Louis, Johanna L; El Jellas, Khadija; Velasco, Kelly; Slipp, Brittany A; Hu, Jiang; Helgeland, Geir; Steine, Solrun J; De Jesus, Dario F; Kulkarni, Rohit N; Molven, Anders.

J Biol Chem ; 299(8): 104986, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37392854

3.

RNA-Binding Protein HuD Controls Insulin Translation.

Lee, Eun Kyung; Kim, Wook; Tominaga, Kumiko; Martindale, Jennifer L; Yang, Xiaoling; Subaran, Sarah S; Carlson, Olga D; Mercken, Evi M; Kulkarni, Rohit N; Akamatsu, Wado; Okano, Hideyuki; Perrone-Bizzozero, Nora I; de Cabo, Rafael; Egan, Josephine M; Gorospe, Myriam.

Mol Cell ; 80(6): 1135, 2020 Dec 17.

Artigo em Inglês | MEDLINE | ID: mdl-33338402

4.

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.

Takatani, Tomozumi; Shirakawa, Jun; Shibue, Kimitaka; Gupta, Manoj K; Kim, Hyunki; Lu, Shusheng; Hu, Jiang; White, Morris F; Kennedy, Robert T; Kulkarni, Rohit N.

J Biol Chem ; 296: 100646, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33839150

5.

Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation.

Teo, Adrian Kee Keong; Nguyen, Linh; Gupta, Manoj K; Lau, Hwee Hui; Loo, Larry Sai Weng; Jackson, Nicholas; Lim, Chang Siang; Mallard, William; Gritsenko, Marina A; Rinn, John L; Smith, Richard D; Qian, Wei-Jun; Kulkarni, Rohit N.

J Biol Chem ; 296: 100495, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33667549

6.

Attenuation of PKCÎ´ enhances metabolic activity and promotes expansion of blood progenitors.

Rao, Tata Nageswara; Gupta, Manoj K; Softic, Samir; Wang, Leo D; Jang, Young C; Thomou, Thomas; Bezy, Olivier; Kulkarni, Rohit N; Kahn, C Ronald; Wagers, Amy J.

EMBO J ; 37(24)2018 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-30446598

7.

New-found brake calibrates insulin action in ß-cells.

Kulkarni, Rohit N.

Nature ; 590(7845): 221-223, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33505001

8.

Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of ESKD in Diabetes.

Satake, Eiichiro; Saulnier, Pierre-Jean; Kobayashi, Hiroki; Gupta, Manoj K; Looker, Helen C; Wilson, Jonathan M; Md Dom, Zaipul I; Ihara, Katsuhito; O'Neil, Kristina; Krolewski, Bozena; Pipino, Caterina; Pavkov, Meda E; Nair, Viji; Bitzer, Markus; Niewczas, Monika A; Kretzler, Matthias; Mauer, Michael; Doria, Alessandro; Najafian, Behzad; Kulkarni, Rohit N; Duffin, Kevin L; Pezzolesi, Marcus G; Kahn, C Ronald; Nelson, Robert G; Krolewski, Andrzej S.

J Am Soc Nephrol ; 32(9): 2331-2351, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34140396

9.

Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.

Loo, Larry Sai Weng; Vethe, Heidrun; Soetedjo, Andreas Alvin Purnomo; Paulo, Joao A; Jasmen, Joanita; Jackson, Nicholas; Bjørlykke, Yngvild; Valdez, Ivan A; Vaudel, Marc; Barsnes, Harald; Gygi, Steven P; Raeder, Helge; Teo, Adrian Kee Keong; Kulkarni, Rohit N.

Stem Cells ; 38(4): 542-555, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-31828876

10.

Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway.

Shirakawa, Jun; Tajima, Kazuki; Okuyama, Tomoko; Kyohara, Mayu; Togashi, Yu; De Jesus, Dario F; Basile, Giorgio; Kin, Tatsuya; Shapiro, A M James; Kulkarni, Rohit N; Terauchi, Yasuo.

Diabetologia ; 63(3): 577-587, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31897526

11.

Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion.

El Ouaamari, Abdelfattah; O-Sullivan, InSug; Shirakawa, Jun; Basile, Giorgio; Zhang, Wenwei; Roger, Sandra; Thomou, Thomas; Xu, Shanshan; Qiang, Guifen; Liew, Chong Wee; Kulkarni, Rohit N; Unterman, Terry G.

J Biol Chem ; 294(3): 1059-1069, 2019 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-30459233

12.

Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in ß-Cells.

Lee, Miseon; Maji, Basudeb; Manna, Debasish; Kahraman, Sevim; Elgamal, Ruth M; Small, Jonnell; Kokkonda, Praveen; Vetere, Amedeo; Goldberg, Jacob M; Lippard, Stephen J; Kulkarni, Rohit N; Wagner, Bridget K; Choudhary, Amit.

J Am Chem Soc ; 142(14): 6477-6482, 2020 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-32175731

13.

RNA-binding protein HuD controls insulin translation.

Lee, Eun Kyung; Kim, Wook; Tominaga, Kumiko; Martindale, Jennifer L; Yang, Xiaoling; Subaran, Sarah S; Carlson, Olga D; Mercken, Evi M; Kulkarni, Rohit N; Akamatsu, Wado; Okano, Hideyuki; Perrone-Bizzozero, Nora I; de Cabo, Rafael; Egan, Josephine M; Gorospe, Myriam.

Mol Cell ; 45(6): 826-35, 2012 Mar 30.

Artigo em Inglês | MEDLINE | ID: mdl-22387028

14.

Correction to: Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.

Xi, Yannan; Liu, Siming; Bettaieb, Ahmed; Matsuo, Kosuke; Matsuo, Izumi; Hosein, Ellen; Chahed, Samah; Wiede, Florian; Zhang, Sheng; Zhang, Zhong-Yin; Kulkarni, Rohit N; Tiganis, Tony; Haj, Fawaz G.

Diabetologia ; 67(1): 215, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37861718

15.

Signaling between pancreatic ß cells and macrophages via S100 calcium-binding protein A8 exacerbates ß-cell apoptosis and islet inflammation.

Inoue, Hideaki; Shirakawa, Jun; Togashi, Yu; Tajima, Kazuki; Okuyama, Tomoko; Kyohara, Mayu; Tanaka, Yui; Orime, Kazuki; Saisho, Yoshifumi; Yamada, Taketo; Shibue, Kimitaka; Kulkarni, Rohit N; Terauchi, Yasuo.

J Biol Chem ; 293(16): 5934-5946, 2018 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-29496993

16.

Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells.

Yi, Lian; Tsai, Chia-Feng; Dirice, Ercument; Swensen, Adam C; Chen, Jing; Shi, Tujin; Gritsenko, Marina A; Chu, Rosalie K; Piehowski, Paul D; Smith, Richard D; Rodland, Karin D; Atkinson, Mark A; Mathews, Clayton E; Kulkarni, Rohit N; Liu, Tao; Qian, Wei-Jun.

Anal Chem ; 91(9): 5794-5801, 2019 05 07.

Artigo em Inglês | MEDLINE | ID: mdl-30843680

17.

How, When, and Where Do Human ß-Cells Regenerate?

Basile, Giorgio; Kulkarni, Rohit N; Morgan, Noel G.

Curr Diab Rep ; 19(8): 48, 2019 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-31250214

18.

Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27^Kip1 levels and poor prognosis.

Kim, Chongtae; Jeong, Da Eun; Heo, Sungeun; Ji, Eunbyul; Rho, Jun Gi; Jung, Myeongwoo; Ahn, Sojin; Kim, Ye-Jin; Kim, Yong-Sung; Nam, Suk Woo; Kulkarni, Rohit N; Lee, Kyoung Bun; Lee, Eun Kyung; Kim, Wook.

J Pathol ; 246(2): 231-243, 2018 10.

Artigo em Inglês | MEDLINE | ID: mdl-30014466

19.

Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells.

Shin, Hanho; Han, Ji Hye; Yoon, Juhwan; Sim, Hyo Jung; Park, Tae Joo; Yang, Siyoung; Lee, Eun Kyung; Kulkarni, Rohit N; Egan, Josephine M; Kim, Wook.

J Cell Mol Med ; 22(4): 2337-2345, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29431265

20.

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

Dirice, Ercument; Ng, Raymond W S; Martinez, Rachael; Hu, Jiang; Wagner, Florence F; Holson, Edward B; Wagner, Bridget K; Kulkarni, Rohit N.

J Biol Chem ; 292(43): 17598-17608, 2017 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-28860191

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