Detalhe da pesquisa
1.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922757
2.
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response.
Immunohorizons
; 6(7): 432-446, 2022 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35817532
3.
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Cell Chem Biol
; 28(8): 1158-1168.e13, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705687
4.
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Cancer Cell
; 39(9): 1214-1226.e10, 2021 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375612
5.
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Diabetes
; 54(5): 1340-8, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15855318
6.
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.
Cell Rep
; 15(3): 574-587, 2016 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068473
7.
Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.
Cell Rep
; 13(5): 1033-45, 2015 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26565915
8.
Involvement of the serotonergic system in orexin-induced behavioral alterations in rats.
Regul Pept
; 104(1-3): 119-23, 2002 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11830286
9.
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.
Science
; 340(6132): 626-30, 2013 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23558169
10.
Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.
Transl Oncol
; 5(6): 422-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23323157
11.
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.
ACS Med Chem Lett
; 3(10): 850-5, 2012 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900389
12.
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.
Chem Biol
; 19(9): 1187-98, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22999886
13.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
J Med Chem
; 54(12): 4092-108, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21608528
14.
PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.
Cancer Res
; 71(8): 3052-65, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493594
15.
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Cancer Res
; 70(4): 1524-33, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20145145
16.
FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
Cancer Res
; 68(7): 2340-8, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18381441
17.
Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.
J Biol Chem
; 277(48): 46586-93, 2002 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12324459