Detalhe da pesquisa
1.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem
; 85: 117273, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030194
2.
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Bioorg Med Chem Lett
; 25(6): 1196-205, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686852
3.
Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells after transplantation.
Haematologica
; 104(7): e284-e287, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30679321
4.
Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation.
Blood Adv
; 6(1): 108-120, 2022 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625796
5.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem
; 65(5): 4291-4317, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179904
6.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
7.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg Med Chem Lett
; 19(5): 1451-6, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19201606
8.
The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.
J Pharmacol Exp Ther
; 324(2): 576-86, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17986646
9.
Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
Bioorg Med Chem Lett
; 18(6): 1939-44, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18291645
10.
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
J Med Chem
; 61(3): 681-694, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316397
11.
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
Diabetes
; 55(1): 240-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16380499
12.
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.
J Med Chem
; 60(4): 1417-1431, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28112924
13.
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
ACS Med Chem Lett
; 7(6): 590-4, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326332
14.
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
J Med Chem
; 53(7): 2854-64, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218621
15.
The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.
J Pharmacol Exp Ther
; 321(1): 107-15, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17259449
16.
5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.
Bioorg Med Chem Lett
; 14(20): 5067-70, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380200
17.
Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.
Bioorg Med Chem Lett
; 13(7): 1337-40, 2003 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12657277