[Comparative study of drug and dietary correction of dyslipoproteinemias among the population]. / Sravnitel'noe izuchenie medikamentoznoi i dieticheskoi korrektsii dislipoproteidemii v populiatsii.

A comparative study of diet and drug correction of dyslipoproteinemias in individuals with stable hypercholesterolemia showed that following a month of diet treatment of groups selected for the therapy with probucol and ascorbic acid there was a clear-cut decrease in the level of plasma cholesterol. The administration of probucol in combination with the diet therapy decreased cholesterol by 33.6%, triglycerides by 32.8% and high density lipoprotein cholesterol (HDLC) by 19.7% as compared with the baseline values. Ascorbic acid showed virtually no effect on the lipid spectrum of the blood. Throughout the entire period of treatment, the patients in these groups showed a reduction in the body weight and blood pressure. In the group receiving only drug therapy, probucol use was associated with a statistically significant decrease in both total cholesterol and HDLC, with the HDLC/cholesterol ratio remaining almost unaltered while in the group receiving diet and probucol, the proportion of HDLC with regard to total cholesterol was elevated as against the initial values. The body weight in this group of patients remained actually unaltered.