Volunteering and political participation are differentially associated with eudaimonic and social well-being across age groups and European countries.

Voluntary participation is thought to promote the well-being of engaged individuals, especially in old age, but prior evidence on this link is mixed. In the present studies, we used the cross-sectional data from Round 6 (2012) of the European Social Survey (ESS) to investigate the variation in the associations between voluntary participation and eudaimonic (e.g., sense of direction) and social (e.g., perceived social support) well-being across types of participation (nonpolitical volunteering vs. political participation), age groups, and European countries. Study 1 addressed individual-level associations and age differences therein (preregistered at https://osf.io/2p9sz and https://osf.io/6twqe). Two-level multiple regression with an extensive set of control variables showed that at the within-country level, the associations between voluntary participation and well-being indicators were small on average. Nonpolitical volunteering had significantly more positive effects than did political participation, whereas few significant age differences emerged. Study 2 focused on the country-level variables that might explain the substantial cross-national variation in the main effects of voluntary participation (preregistered at https://osf.io/mq3dx). Only GDP per capita was a significant moderator at the country level: The associations of nonpolitical volunteering with eudaimonic well-being were more positive in the European countries with lower GDP. Other country-level variables (Gini coefficient, social welfare spending, and democracy indices) yielded no consistent moderation effects. Study 3 considered potential country-level explanations for the substantial cross-national variation in whether younger or older adults appeared to benefit more (preregistered at https://osf.io/7ks45). None of the country-level variables considered (effective retirement age in men, life expectancy at 65, average age of members of the national parliament and cabinet, and youth unemployment rate) could account for this variation. We conclude that, given the large cross-national variation in the effects of voluntary participation on well-being and in age differences therein, more attention to national specifics is warranted.

Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens.

CFTR mutations enhance susceptibility for idiopathic chronic pancreatitis (ICP) and congenital bilateral absence of the vas deferens (CBAVD); however, it is unknown why CFTR heterozygotes are at increased disease risk. We recently showed that common CFTR variants are associated with aberrantly spliced transcripts. Here, we genotyped for common CFTR variants and tested for associations in two ICP (ICP-A: 126 patients, 319 controls; ICP-B: 666 patients, 1,181 controls) and a CBAVD population (305 patients, 319 controls). Haplotype H10 (TG11-T7-470V) conferred protection (ICP-A: OR 0.19, P<0.0001; ICP-B: OR 0.78, P = 0.06; CBAVD OR 0.08, P<0.001), whereas haplotype H3 (TG10-T7-470M) increased disease risk (ICP-A: OR 8.34, P = 0.003; ICP-B: OR 1.88, P = 0.007; CBAVD: OR 5.67, P = 0.01). The risk of heterozygous CFTR mutations carriers for ICP (OR 2.44, P<0.001) and CBAVD (OR 14.73, P<0.001) was fully abrogated by the H10/H10 genotype. Similarly, ICP risk of heterozygous p.Asn34Ser SPINK1 mutation carriers (OR 10.34, P<0.001) was compensated by H10/H10. Thus, common CFTR haplotypes modulate ICP and CBAVD susceptibility alone and in heterozygous CFTR and p.Asn34Ser mutation carriers. Determination of these haplotypes helps to stratify carriers into high- and low-risk subjects, providing helpful information for genetic counseling.

Effects of voluntary memberships and volunteering on alcohol and tobacco use across the life course: Findings from the German Socio-Economic Panel.

BACKGROUND: It is unclear whether specific components of individual social capital promote or protect against substance use and whether such effects vary across the life course. In this study, we investigated the effects of voluntary memberships and volunteering on alcohol and tobacco consumption in age comparison. METHODS: Preregistration is accessible at https://osf.io/qhkrn/. We used data from the German Socio-Economic Panel (1984-2015), where alcohol consumption was assessed in 2006, 2008, and 2010 and smoking was assessed at least biennially since 1998. We divided participants into three age groups (14-29, 40-50, and 65-75 years of age at baseline). To disentangle intraindividual change over time and interindividual differences (potential selection effects), we employed multilevel analysis. RESULTS: At the within level, voluntary memberships at one occasion predicted higher alcohol consumption a year later in middle-aged and older adults, but memberships had no significant longitudinal effects on smoking. Several positive effects of volunteering on alcohol and tobacco use one year later were found in males. No significant differences in the longitudinal effects between age groups or between nonpolitical and political volunteering emerged. At the between level, voluntary memberships and volunteering were usually associated with more alcohol consumption at low and moderate levels but with less smoking. DISCUSSION: Over time, voluntary memberships and volunteering in Germany appear to promote, rather than to protect against, alcohol and tobacco use. On average, more engaged individuals drink more (at moderate levels) and smoke less, which may be due to selection effects.

Does participation in voluntary organizations protect against risky alcohol and tobacco use? Findings from the UK panel data.

Drawing on the literature that posits heterogeneous influences of social networks on health behaviors, we tested whether different forms of participation in voluntary organizations predicted more or less alcohol and tobacco consumption over time. (Access preregistration at https://osf.io/guzem/) We used panel data from younger (aged 14-29 at baseline), middle-aged (aged 40-50), and older (aged 65-75) UK adults, Ns = 1280-9073, followed from 1991 to 2014. Annual measures of smoking included status and intensity. Frequency of pub attendance was assessed biennially between 1996 and 2008. In 2010 and 2013, more precise measures of alcohol consumption were available. We conducted two-level regression analyses for the outcomes measured more than twice and residual change analyses for other outcomes. Over time (within persons), there were no significant effects on smoking. Activity in voluntary organizations predicted slightly less frequent pub attendance in younger adults. In residual change analyses, activity in voluntary organizations decreased last-week ethanol consumption and risk of heavy episodic drinking in younger women. These effects pertained mainly to service-orientated organizations. In middle-aged adults, membership and attendance at meetings of voluntary organizations predicted slightly more frequent pub attendance. Residual change analyses showed volunteering to reduce the risk of heavy episodic drinking in middle-aged men. In older adults, few significant effects emerged. Between persons, all indicators of participation were associated with less smoking, whereas membership was associated with more and activity with less frequent pub attendance. Thus, most associations between participation in voluntary organizations and substance use reflected interindividual differences.