Detalhe da pesquisa
1.
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer.
J Am Chem Soc
; 145(1): 537-550, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36542059
2.
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.
Xenobiotica
; 52(3): 240-253, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35382680
3.
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Bioorg Med Chem
; 41: 116205, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34000509
4.
Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis.
Magn Reson Chem
; 55(4): 348-354, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469271
5.
Stereoselective synthesis of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile.
J Org Chem
; 77(10): 4732-9, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524537
6.
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Bioorg Med Chem Lett
; 22(18): 5989-94, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892121
7.
Diversification of a ß-Lactam Pharmacophore via Allylic C-H Amination: Accelerating Effect of Lewis Acid Co-Catalyst.
Tetrahedron
; 66(26): 4816-4826, 2010 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21379377
8.
Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H1 Receptor Inverse Agonist.
J Med Chem
; 63(13): 7268-7292, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32462865
9.
5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett
; 19(18): 5302-6, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683922
10.
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
J Mol Biol
; 354(4): 854-71, 2005 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16288920
11.
Inhibitors of 3C cysteine proteinases from Picornaviridae.
Curr Top Med Chem
; 4(12): 1239-53, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15320724
12.
Pyridone-conjugated monobactam antibiotics with gram-negative activity.
J Med Chem
; 56(13): 5541-52, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23755848
13.
Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles.
Bioorg Med Chem Lett
; 17(16): 4694-8, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17590334
14.
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.
J Org Chem
; 67(5): 1536-47, 2002 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11871884